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How money, mail and power affect our health

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Saturday, July 27, 2024

Marty Makary’s July 12 op-ed, “For a wasteful Medicare rule, location is everything,” made a clear case: Too many Americans have been blindly led into a health-care affordability crisis. Even if they never set foot in a hospital, patients receiving care from hospital-affiliated providers face higher prices caused by so-called site-of-service payment differentials. As a community oncologist, it angers me to see these disparities sometimes triple costs for services such as chemotherapy.These payment differentials incentivize hospitals to acquire independent practices to boost their revenue. The differentials also drive health systems to further expand their market share through anti-competitive tactics. After my practice refused an acquisition attempt from a large health system, my oncology privileges were revoked — leaving me unable to provide care to my own cancer patients when they were admitted to the hospital. Restricting trusted care teams leaves patients confused, frustrated and in the dark.This trend is bad news for everyone — except hospitals. To prevent such practices from becoming widespread, Congress must pass the Lower Costs, More Transparency Act without delay.Moshe Chasky, Bensalem, Pa.So-called site-neutral policies fail to recognize that not all care sites are created equal. Current payment rates appropriately take into account that hospitals treat sicker, lower-income and more complex patients compared with other sites. Hospitals are also held to higher regulatory and safety standards, and they provide benefits such as 24/7 capacity for emergencies. The argument also disregards the fact that the lower rate paid to physicians is completely inadequate, as we hear from them all the time.Medicare already reimburses hospitals just 82 cents for every dollar spent caring for patients. Additional site-neutral cuts, like those supported by the writer, would exacerbate these shortfalls. Medicare also fails to cover the full costs of resident salaries for teaching hospitals, which is a far cry from the “big bonuses” the author alleged Medicare’s graduate medical education program gives to hospitals.Physician polling data has shown that the burden from corporate insurers is driving physicians away from independent practices. Physicians are also seeking to become integrated with hospitals because of the costs associated with technologies such as electronic health records. And it is corporate health insurers that have been driving independent practice acquisitions for the past five years, not hospitals.Instead of advocating flawed policy proposals, let’s focus on ways we can support hospitals and health systems and ensure they can be there for their communities.The writer is president and chief executive of the American Hospital Association.The mail isn’t just mailRegarding Postmaster General Louis DeJoy’s July 8 online op-ed, “We’re fixing the Postal Service. We can’t stop now.”:Within the past three years, many of Mr. DeJoy’s proposed “cost-saving measures” include closing some processing centers and trucking mail to other consolidation centers. This might sound good at first glance, but it fails in reality.The Upper Peninsula Processing Facility in Kingsford, Mich., processes mail for the entire Upper Peninsula, which it has done faithfully for years. Now, there is talk of closing it. Mail from the region would be shipped to Green Bay, Wis., a four-hour round-trip drive in good weather. If the processing center closes, jobs will be lost and the fragile mail-delivery system will be further threatened.Before there was any talk of closure, the Postal Service changed its trucking schedule and stopped offering overnight shipping, which endangered the health of every man, woman and child who lives in the Upper Peninsula of Michigan. How so? Two words: water samples. The Environmental Protection Agency requires that drinking water in the United States be tested for bacterial infection. Such testing is critical to fighting waterborne illnesses such as dysentery and typhoid fever.For water testing to be accurate, it must be completed within a short time frame. There is only one lab in the Upper Peninsula, White Water Associates, that tests all of the water samples from the region. Until Jan. 8, it had been possible for water samples sent anywhere in the Upper Peninsula to reach White Water Associates in time for testing. That is no longer possible, which is resulting in expired samples. Without valid water testing, the chances of outbreaks of waterborne illnesses greatly increase. The shipping changes have made it next to impossible for water to be tested within the required time frame.The Postal Service is vital for Americans. It doesn’t just deliver letters and packages; it also delivers medicine, water testing kits and, yes, absentee ballots. Postal workers are doing their best to deliver our nations’ mail, and they deserve to work under a postmaster general who understands the effects of his policies. The postmaster general should not care only about swift delivery of packages. He or she should also understand that, for many people who live in rural America, mail is a lifeline to the rest of the world.Mr. DeJoy’s actions have endangered that lifeline, and for that, he should be replaced. To ensure the health of our nation’s water supply, Postal Service trucking schedules must return to how they were before Jan. 8. To refuse to do so is to raise the question: Is the Postal Service attempting to save money at the expense of Americans’ lives?Tracy Asanuma, Iron Mountain, Mich.In a stunning display of denial, Postmaster General Louis DeJoy’s recent op-ed attempts to sugarcoat the disastrous effects of his leadership.Mr. DeJoy suggests the Postal Service was a sinking ship upon his arrival, but his “Delivering for America” plan — which raised prices, slashed services and shuttered post offices nationwide — has only made a precarious situation worse. His publicly proclaimed goal to hike prices to “uncomfortable” rates shows a shocking disregard for the needs of everyday Americans, including seniors, rural residents and small-business owners. His plan to close and consolidate up to 10,000 offices, stations, branches and annexes betrays the Postal Service’s mission to serve every community. Just look at Georgia, where the plan’s initial stages have thrown mail delivery into chaos.But don’t just take it from us. After congressional leaders urged the Postal Regulatory Commission to reject the latest price increases, the commission itself expressed concern that the plan “does not reflect reasoned consideration of the potential widespread effects,” is imprudent and is not in the best interests of stakeholders. This stinging critique underscores the urgent need for a change in leadership. Mr. DeJoy has attempted to run the Postal Service like a hedge fund manager intent on gutting an enterprise to show short-term revenue improvements. But America needs the Postal Service for the long term; it is an institution that binds the country together, providing critical deliveries on items like Social Security checks, medications and mail-in ballots. We need investments and innovation, not service cuts.The future of the Postal Service depends on bold leadership and an unwavering commitment to its public service mission. Time and time again, Mr. DeJoy has shown he is simply not up to the task.Raja Krishnamoorthi and Robert Weissman, WashingtonRaja Krishnamoorthi, a Democrat, represents Illinois’s 8th Congressional District in the House. Robert Weissman is co-president of public interest at Public Citizen.Postmaster General Louis DeJoy’s op-ed failed to mention the relentless price hikes under a well-intended but struggling strategic plan. July 14 marked the fifth increase in three years, covering mail, newspapers, magazines, catalogues and more. Package prices have also been raised significantly, and the price of the first-class “forever” stamp is now 73 cents.These recent price increases total more than 184 percent of inflation. Businesses and customers are stressed trying to keep up, not only on price but also as service has declined.America needs a reliable, affordable postal system for everyone. We urge Congress to better invest Postal Service funds and strengthen regulatory oversight to preserve the Postal Service’s viability and sustainability.The writer is executive director of the Coalition for a 21st Century Postal Service.Postmaster General Louis DeJoy’s op-ed was outrageous. Mail delivery is worse than ever in Houston, and it interferes with doing business. And the danger for mail-in ballots with a reduced Postal Service is alarming. The blame is squarely on the postmaster general, not the local postmasters or carriers who cannot believe what is happening.Fredericka Hunter, HoustonPower in TexasMore than 1 million of us in Houston had no power for days after Hurricane Beryl. I was one of them.This isn’t the first time this has happened. It happened in 2021, when more than 200 Texans died because of power outages from extreme cold. Massive outages also happened with Hurricanes Harvey and Ike. More than 15 years after Ike, there is still no “Ike Dike.”The Texas GOP can’t keep the lights on while it wastes billions of dollars on a wall on the southern U.S. border. During Hurricane Beryl, Gov. Greg Abbott (R) was off in Asia. The chief executive of CenterPoint Energy makes more than $1 million as a base salary, not to mention other bonuses. Meanwhile, we regular people sit in the dark and sweat.Michael Fjetland, Houston

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Marty Makary’s July 12 op-ed, “For a wasteful Medicare rule, location is everything,” made a clear case: Too many Americans have been blindly led into a health-care affordability crisis. Even if they never set foot in a hospital, patients receiving care from hospital-affiliated providers face higher prices caused by so-called site-of-service payment differentials. As a community oncologist, it angers me to see these disparities sometimes triple costs for services such as chemotherapy.

These payment differentials incentivize hospitals to acquire independent practices to boost their revenue. The differentials also drive health systems to further expand their market share through anti-competitive tactics. After my practice refused an acquisition attempt from a large health system, my oncology privileges were revoked — leaving me unable to provide care to my own cancer patients when they were admitted to the hospital. Restricting trusted care teams leaves patients confused, frustrated and in the dark.

This trend is bad news for everyone — except hospitals. To prevent such practices from becoming widespread, Congress must pass the Lower Costs, More Transparency Act without delay.

Moshe Chasky, Bensalem, Pa.

So-called site-neutral policies fail to recognize that not all care sites are created equal. Current payment rates appropriately take into account that hospitals treat sicker, lower-income and more complex patients compared with other sites. Hospitals are also held to higher regulatory and safety standards, and they provide benefits such as 24/7 capacity for emergencies. The argument also disregards the fact that the lower rate paid to physicians is completely inadequate, as we hear from them all the time.

Medicare already reimburses hospitals just 82 cents for every dollar spent caring for patients. Additional site-neutral cuts, like those supported by the writer, would exacerbate these shortfalls. Medicare also fails to cover the full costs of resident salaries for teaching hospitals, which is a far cry from the “big bonuses” the author alleged Medicare’s graduate medical education program gives to hospitals.

Physician polling data has shown that the burden from corporate insurers is driving physicians away from independent practices. Physicians are also seeking to become integrated with hospitals because of the costs associated with technologies such as electronic health records. And it is corporate health insurers that have been driving independent practice acquisitions for the past five years, not hospitals.

Instead of advocating flawed policy proposals, let’s focus on ways we can support hospitals and health systems and ensure they can be there for their communities.

The writer is president and chief executive of the American Hospital Association.

The mail isn’t just mail

Regarding Postmaster General Louis DeJoy’s July 8 online op-ed, “We’re fixing the Postal Service. We can’t stop now.”:

Within the past three years, many of Mr. DeJoy’s proposed “cost-saving measures” include closing some processing centers and trucking mail to other consolidation centers. This might sound good at first glance, but it fails in reality.

The Upper Peninsula Processing Facility in Kingsford, Mich., processes mail for the entire Upper Peninsula, which it has done faithfully for years. Now, there is talk of closing it. Mail from the region would be shipped to Green Bay, Wis., a four-hour round-trip drive in good weather. If the processing center closes, jobs will be lost and the fragile mail-delivery system will be further threatened.

Before there was any talk of closure, the Postal Service changed its trucking schedule and stopped offering overnight shipping, which endangered the health of every man, woman and child who lives in the Upper Peninsula of Michigan. How so? Two words: water samples. The Environmental Protection Agency requires that drinking water in the United States be tested for bacterial infection. Such testing is critical to fighting waterborne illnesses such as dysentery and typhoid fever.

For water testing to be accurate, it must be completed within a short time frame. There is only one lab in the Upper Peninsula, White Water Associates, that tests all of the water samples from the region. Until Jan. 8, it had been possible for water samples sent anywhere in the Upper Peninsula to reach White Water Associates in time for testing. That is no longer possible, which is resulting in expired samples. Without valid water testing, the chances of outbreaks of waterborne illnesses greatly increase. The shipping changes have made it next to impossible for water to be tested within the required time frame.

The Postal Service is vital for Americans. It doesn’t just deliver letters and packages; it also delivers medicine, water testing kits and, yes, absentee ballots. Postal workers are doing their best to deliver our nations’ mail, and they deserve to work under a postmaster general who understands the effects of his policies. The postmaster general should not care only about swift delivery of packages. He or she should also understand that, for many people who live in rural America, mail is a lifeline to the rest of the world.

Mr. DeJoy’s actions have endangered that lifeline, and for that, he should be replaced. To ensure the health of our nation’s water supply, Postal Service trucking schedules must return to how they were before Jan. 8. To refuse to do so is to raise the question: Is the Postal Service attempting to save money at the expense of Americans’ lives?

Tracy Asanuma, Iron Mountain, Mich.

In a stunning display of denial, Postmaster General Louis DeJoy’s recent op-ed attempts to sugarcoat the disastrous effects of his leadership.

Mr. DeJoy suggests the Postal Service was a sinking ship upon his arrival, but his “Delivering for America” plan — which raised prices, slashed services and shuttered post offices nationwide — has only made a precarious situation worse. His publicly proclaimed goal to hike prices to “uncomfortable” rates shows a shocking disregard for the needs of everyday Americans, including seniors, rural residents and small-business owners. His plan to close and consolidate up to 10,000 offices, stations, branches and annexes betrays the Postal Service’s mission to serve every community. Just look at Georgia, where the plan’s initial stages have thrown mail delivery into chaos.

But don’t just take it from us. After congressional leaders urged the Postal Regulatory Commission to reject the latest price increases, the commission itself expressed concern that the plan “does not reflect reasoned consideration of the potential widespread effects,” is imprudent and is not in the best interests of stakeholders. This stinging critique underscores the urgent need for a change in leadership. Mr. DeJoy has attempted to run the Postal Service like a hedge fund manager intent on gutting an enterprise to show short-term revenue improvements. But America needs the Postal Service for the long term; it is an institution that binds the country together, providing critical deliveries on items like Social Security checks, medications and mail-in ballots. We need investments and innovation, not service cuts.

The future of the Postal Service depends on bold leadership and an unwavering commitment to its public service mission. Time and time again, Mr. DeJoy has shown he is simply not up to the task.

Raja Krishnamoorthi and Robert Weissman, Washington

Raja Krishnamoorthi, a Democrat, represents Illinois’s 8th Congressional District in the House. Robert Weissman is co-president of public interest at Public Citizen.

Postmaster General Louis DeJoy’s op-ed failed to mention the relentless price hikes under a well-intended but struggling strategic plan. July 14 marked the fifth increase in three years, covering mail, newspapers, magazines, catalogues and more. Package prices have also been raised significantly, and the price of the first-class “forever” stamp is now 73 cents.

These recent price increases total more than 184 percent of inflation. Businesses and customers are stressed trying to keep up, not only on price but also as service has declined.

America needs a reliable, affordable postal system for everyone. We urge Congress to better invest Postal Service funds and strengthen regulatory oversight to preserve the Postal Service’s viability and sustainability.

The writer is executive director of the Coalition for a 21st Century Postal Service.

Postmaster General Louis DeJoy’s op-ed was outrageous. Mail delivery is worse than ever in Houston, and it interferes with doing business. And the danger for mail-in ballots with a reduced Postal Service is alarming. The blame is squarely on the postmaster general, not the local postmasters or carriers who cannot believe what is happening.

Fredericka Hunter, Houston

Power in Texas

More than 1 million of us in Houston had no power for days after Hurricane Beryl. I was one of them.

This isn’t the first time this has happened. It happened in 2021, when more than 200 Texans died because of power outages from extreme cold. Massive outages also happened with Hurricanes Harvey and Ike. More than 15 years after Ike, there is still no “Ike Dike.”

The Texas GOP can’t keep the lights on while it wastes billions of dollars on a wall on the southern U.S. border. During Hurricane Beryl, Gov. Greg Abbott (R) was off in Asia. The chief executive of CenterPoint Energy makes more than $1 million as a base salary, not to mention other bonuses. Meanwhile, we regular people sit in the dark and sweat.

Michael Fjetland, Houston

Read the full story here.
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Gas stove makers quietly delete air pollution warnings as they fight mandatory health labels

Manufacturers sued to stop a Colorado law requiring air quality warnings, arguing gas stoves are safe. Some of their websites once said the opposite.

The home appliance industry would like you to believe that gas-burning stoves are not a risk to your health — and several companies that make the devices are scrambling to erase their prior acknowledgements that they are.  That claim is at the heart of a lawsuit the Association of Home Appliance Manufacturers has filed against the state of Colorado to stop it from requiring natural gas stoves, which burn methane, to carry health labels not unlike those on every pack of cigarettes. “Understand the air quality implications of having an indoor gas stove,” the warning would read. The law was to take effect August 5 but is now on hold, and state officials did not respond to a request for comment. In its federal lawsuit, the Association — whose board includes representatives of LG Electronics, BSH Home Appliance Corp. (which makes Bosch appliances), Whirlpool, and Samsung Electronics — asserts that the labeling requirement is “unconstitutional compelled speech” and illegal under the First Amendment. It calls the legislation a climate law disguised as a health law and, most strikingly, it claims there is “no association between gas stoves and adverse health outcomes.”  Yet LG, BSH, Whirlpool, and Samsung have published information on their websites directly contradicting that claim and lauded the health benefits of electric and induction stoves.  “Traditional gas appliances can emit harmful pollutants, which can compromise indoor air quality and pose health risks,” reads a blog post, titled “Life’s Good When It’s Electrified,” that LG published in May of 2024. “By switching to electric appliances, these risks are substantially reduced, ensuring a cleaner and safer home environment.”  Another LG page noted that “induction surfaces remain cool to the touch and unlike gas, is better for kitchen air quality” as recently as May 25, according to an archived version of the site maintained by Wayback Machine. It was later revised to eliminate mention of gas, reading “Surfaces remain cool to the touch — no open flames or hot coils. No fumes, either, so it’s [sic] air quality-friendly.” BSH’s page on Bosch induction cooktops notes that the devices are “safer to use because unlike other types of cooktops, they do not release indoor air pollutants during cooking.” Whirlpool wrote that induction cooktops might help “reduce indoor air pollutants.”  And until last week, a page on Samsung’s U.S. website said “induction cooktops can … help remove concerns over indoor air pollution, creating a sustainable and healthier home environment. The page’s source code did not appear to have been updated since 2022. Samsung did not respond to multiple requests for comment, but the page was taken down shortly after Grist reached out to the company.  Itai Vardi, a researcher with the Energy and Policy Institute, was the first to notice the discrepancies between what the Association said in its lawsuit and what some of its manufacturers have said in the past. “The statements coming from them directly contradict the very strong language in this lawsuit,” Vardi said. “And that, I think, deserves some scrutiny.” Scientific evidence that gas stoves pollute by releasing dangerous concentrations of nitrogen dioxide, benzene, and methane has accumulated since 1970. Justin Paget / Getty Images In its lawsuit, the Association argues that “the potential health risks of cooking with gas are no different than cooking with electricity” and acknowledging the ways gas-burning appliances can harm respiratory health promotes “non-consensus, scientifically controversial, and factually misleading” messages. It adds that “there is scant scientific support” for disclosing health risks associated with gas appliances.  Asked for comment, the organization referred to a statement it issued August 6 saying “no study has found that gas stoves cause respiratory health issues.”  When reached for comment, a BSH representative stated that the company is as of now “in complete alignment” with the Association’s position. An LG representative noted that the most pollution-acknowledging statements on their website were in fact made by the company’s UK branch, but did not respond to a follow-up question about whether the UK and US divisions disagree on the risks of LG products. “This is a troubling attempt by these companies’ to quickly erase their own public acknowledgement of the dangers of gas stoves,” said Vardi. “But you can scrub your website, not the fact of gas stove pollution.”  Scientific evidence that gas stoves pollute by releasing dangerous concentrations of nitrogen dioxide, benzene, and methane has piled up for the past half-century. In 1970, scientist Carl Shy showed that families exposed to high levels of nitrogen dioxide indoors are at greater risk of asthma and other respiratory illnesses than those who are not. Nine years later, scientist Bernard Goldstein identified the fuel as the likely source of all that nitrogen. A bevy of studies and papers in the decades since came to similar conclusions. One 2022 study estimated that 12 percent of American children with asthma develop that respiratory condition solely due to living in homes with gas stoves.  Appliance manufacturers and the natural gas industry are no stranger to promoting their products regardless of known health risks. “There’s been a campaign by industry to keep the science under wraps or to confuse it, deny it,” said Abe Scarr of the consumer-protection nonprofit Public Interest Working Group.  The lobbyists at the American Gas Association have worked hard to popularize gas stoves: At one point, the organization even provided the stoves Julia Child used in her popular cooking show. The campaign went beyond product placement: When information on the health risks of gas stoves began to emerge in the mid-1970s, industry lobbyists launched “Operation Attack,” a million-dollar marketing campaign to bring the stoves into even more kitchens. This worked: today, about 40% of Americans cook with gas. They also funded their own research, which cast doubt on independent findings on the health risks of gas stoves.  Environmental health sciences professor Misbath Daouda of the University of California, Berkeley, was recently part of a pilot study replacing gas stoves in low-income New York City apartments with induction stoves. Nitrogen dioxide concentrations in those apartments, she said, dropped by over 50 percent within months – and the families who lived there liked their new cooktops better than the old ones, she said.  The association between gas stoves and adverse health outcomes, Daouda said, “is clear.”  “I’m not sure who they are referring to when they say the majority of studies” don’t support that conclusion, she said. This story was originally published by Grist with the headline Gas stove makers quietly delete air pollution warnings as they fight mandatory health labels on Sep 17, 2025.

New Biomarker Could Detect Alzheimer’s Years Before Symptoms Appear

TSPO levels rise early in Alzheimer’s and persist throughout disease. Targeting this biomarker could open new treatment options. TSPO, a major marker of brain inflammation, may offer a way to detect Alzheimer’s disease long before memory problems and other symptoms develop. Findings published in Acta Neuropathologica suggest it could transform both diagnosis and treatment strategies. [...]

A new study suggests that TSPO, a key biomarker of brain inflammation, may reveal the earliest stages of Alzheimer’s disease long before symptoms appear. Credit: StockTSPO levels rise early in Alzheimer’s and persist throughout disease. Targeting this biomarker could open new treatment options. TSPO, a major marker of brain inflammation, may offer a way to detect Alzheimer’s disease long before memory problems and other symptoms develop. Findings published in Acta Neuropathologica suggest it could transform both diagnosis and treatment strategies. “This is the first study to really examine how early this biomarker increases and where it begins rising in the brain,” said Tomás R. Guilarte, lead researcher and dean of FIU’s Robert Stempel College of Public Health & Social Work. “If we can use this information to help delay Alzheimer’s progression by even five years, it can drastically improve patients’ lives and reduce disease prevalence.” Longstanding research on TSPO Guilarte, a recognized authority on TSPO (translocator protein 18 kDa), has investigated the protein for more than 30 years. His research helped establish it as a dependable imaging marker for identifying neuroinflammation across multiple neurological, neurodegenerative, and psychiatric conditions. Researchers Daniel Martínez Pérez (L) and Dr. Tomás R. Guilarte (R) in the Brain, Behavior and the Environment Laboratory at Florida International University. Guilarte and Martínez Pérez published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International UniversityFor the current study, Guilarte and colleagues applied advanced imaging techniques to track TSPO activity in genetically engineered mouse models of familial Alzheimer’s. They then validated these results using donated brain tissue from members of the world’s largest community with early-onset familial Alzheimer’s, based in Antioquia, Colombia. These families carry the “paisa” mutation, first identified by the late Dr. Francisco Lopera, a co-author of the study who spent his career searching for ways to prevent Alzheimer’s. Individuals with this genetic variant often develop symptoms in their 30s or 40s and typically die in their 50s. L: The original cell image. R: The same cell image zoomed in and rendered in the special imaging software. Microglia (blue) signaling TSPO (red) are clustered around plaques (cyan). Researchers at Florida International University published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in.  Credit: Chris Necuze, Florida International UniversityEarly changes in the hippocampus In the mouse model, researchers detected elevated TSPO levels in the subiculum – a critical part of the hippocampus – as early as six weeks of age, roughly equivalent to age 18–20 in humans. Microglia, the brain’s main immune cells, specifically those clustered around amyloid plaques, had the highest levels of TSPO. Notably, female mice had higher TSPO levels, mirroring real-world statistics: two-thirds of Alzheimer’s patients are women. Daniel Martínez Pérez holds tissue sample. Martínez Pérez, a researcher in Florida International University’s Robert Stempel College of Public Health & Social Work, is the first author of a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International UniversityThe brain tissue samples from the Colombian patients with the paisa mutation showed the same pattern. Even in late-stage Alzheimer’s, TSPO remained high in microglia near plaques. These results raise new questions about TSPO’s function – whether it contributes to damage or protects the brain – and whether blocking or enhancing it could halt disease progression. Next steps in research The team is now working with a specially developed Alzheimer’s mouse model lacking TSPO to explore these questions further. They’re also expanding the study to include sporadic, late-onset Alzheimer’s cases, the form that accounts for over 90% of all diagnoses. Researchers Dr. Tomás R. Guilarte (L) and Daniel Martínez Pérez (R) in the Brain, Behavior and the Environment Laboratory at Florida International University. Guilarte and Martínez Pérez published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International University“The more we understand these processes,” said Daniel Martínez Pérez, first author and Ph.D. candidate in Guilarte’s lab, “the closer we get to tailoring treatments that can truly help – before it’s too late.” Reference: “Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer’s disease” by Daniel A. Martinez-Perez, Jennifer L. McGlothan, Alexander N. Rodichkin, Karam Abilmouna, Zoran Bursac, Francisco Lopera, Carlos Andres Villegas-Lanau and Tomás R. Guilarte, 17 July 2025, Acta Neuropathologica.DOI: 10.1007/s00401-025-02912-4 This work was supported by grants ES007062-24 to T.R.G. from the National Institute of Environmental Health Sciences (NIEHS), ES007062-23S1 to T.R.G. from the National Institute on Aging, and T32-ES033955 to A.N.R. from the NIEHS. Never miss a breakthrough: Join the SciTechDaily newsletter.

Living Near Polluted Missouri Creek as a Child Tied to Later Cancer Risk

By I. Edwards HealthDay ReporterTHURSDAY, July 17, 2025 (HealthDay News) — Folks who grew up near a polluted Missouri creek during the 1940s...

THURSDAY, July 17, 2025 (HealthDay News) — Folks who grew up near a polluted Missouri creek during the 1940s through 1960s may have higher odds for cancer now, new research shows.The study focused on Coldwater Creek in St. Louis County. The area was contaminated with radioactive waste from the U.S. government’s atomic bomb program during World War II.Back then, uranium was processed in St. Louis and nuclear waste was stored near the city’s airport. That waste leaked into Coldwater Creek, which runs through several residential neighborhoods.Researchers found that people who lived within one kilometer (0.62 miles) of the creek as kids had an 85% higher risk of developing certain cancers later in life compared to those who lived more than 20 kilometers (12.4 miles) away.Those cancers include leukemia, thyroid cancer and breast cancer, which are known to be linked to radiation exposure.“The closer the childhood residence got to Coldwater Creek, the risk of cancer went up, and pretty dramatically," lead researcher Marc Weisskopf, a professor of epidemiology at Harvard T.H. Chan School of Public Health, told The Wall Street Journal.For the study, Weisskopf’s team surveyed more than 4,200 adults who lived in the St. Louis area as children between 1958 and 1970.These people had donated their baby teeth years ago for radiation research. The new survey asked about cancer and other health issues.About 1 in 4 participants said they had been diagnosed with cancer. Risk dropped the farther someone lived from the creek as a child.Outside experts who reviewed the findings described them as concerning.“It emphasizes the importance of appreciating that radioactive waste is carcinogenic, particularly to children, and that we have to ensure that we have to clean up any remaining waste that’s out there,” Dr. Rebecca Smith-Bindman, a radiation risk expert at the University of California, San Francisco, told The Journal.In 2024, the U.S. Army Corps of Engineers began placing warning signs along parts of the creek that still have radioactive waste, The Journal reported.The U.S. Agency for Toxic Substances and Disease Registry reported in 2019 that contamination have raised the risk of leukemia and lung and bone cancer. Later exposures, starting in the 2000s, were linked to a slight increase in lung cancer for those who lived nearby.But the agency said it’s hard to link any one person’s cancer directly to radiation. Genetics, lifestyle and other factors could also play a role.In this study, radiation exposure wasn’t directly measured. Cancer cases were also self-reported, not confirmed by medical records. Weisskopf plans to measure radiation levels using the stored baby teeth in future research.Radiation exposure has long been tied to cancer, but this study is among the first to look at lower, long-term environmental exposure in the U.S., not just high levels from nuclear disasters or bombings."Radiation, when it’s given unnecessarily, only causes risk," Dr. Howard Sandler, chair of radiation oncology at Cedars-Sinai in Los Angeles, told The Journal.SOURCE: The Wall Street Journal, July 16, 2025Copyright © 2025 HealthDay. All rights reserved.

Disposable Vapes Release Toxic Metals, Lab Study Says

By Dennis Thompson HealthDay ReporterFRIDAY, July 11, 2025 (HealthDay News) — People using cheap disposable vape devices are likely inhaling high...

By Dennis Thompson HealthDay ReporterFRIDAY, July 11, 2025 (HealthDay News) — People using cheap disposable vape devices are likely inhaling high levels of toxic metals with every puff, a recent study says.After a few hundred puffs, some disposable vapes start releasing levels of toxic metals higher than found in either last-generation refillable e-cigarettes or traditional tobacco smokes, researchers reported in the journal ACS Central Science.These metals can increase a person’s risk of cancer, lung disease and nerve damage, researchers said.“Our study highlights the hidden risk of these new and popular disposable electronic cigarettes — with hazardous levels of neurotoxic lead and carcinogenic nickel and antimony — which stresses the need for urgency in enforcement,” senior researcher Brett Poulin, an assistant professor of environmental toxicology at the University of California-Davis, said in a news release.Earlier studies found that the heating elements of refillable vapes could release metals like chromium and nickel into the vapor people breathe.For this study, researchers analyzed seven disposable devices from three well-known vape brands: ELF Bars, Flum Pebbles and Esco Bar.Before they were even used, some of the devices had surprisingly high levels of lead and antimony, researchers reported. The lead appears to have come from leaded copper alloys used in the devices, which leach into the e-liquid.The team then activated the disposable vapes, creating between 500 and 1,500 puffs for each device, to see whether their heating elements would release more metals.Analysis of the vapor revealed that:Levels of metals like chromium, nickel and antimony increased as the number of puffs increased, while concentrations of zinc, copper and lead were elevated at the start. Most of the tested disposables released higher amounts of metals than older refillable vapes. One disposable released more lead during a day’s use than one would get from nearly 20 packs of tobacco cigarettes. Nickel in three devices and antimony in two devices exceeded cancer risk limits. Four devices had nickel and lead emissions that surpassed health risk thresholds for diseases other than cancer. These results reflect only three of the nearly 100 disposable vape brands now available on store shelves, researchers noted.“Coupling the high element exposures and health risks associated with these devices and their prevalent use among the underage population, there is an urgent need for regulators to investigate this issue further and exercise regulatory enforcement accordingly,” researchers wrote.SOURCES: American Chemical Society, news release, June 20, 2025; ACS Central Science, June 25, 2025Copyright © 2025 HealthDay. All rights reserved.

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