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Healthy Country, healthy people: how shared knowledge is helping to restore a World Heritage area

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Thursday, August 8, 2024

Community glass artwork by Shark Bay Arts Council members of restored seagrass meadow on display at the Wirriya Jalyanu (seagrass) Festival. Elizabeth Sinclair/UWAPlease be advised that the following article contains images of an Indigenous person who has died, which are used with family permission. Our journey began in 2018 at Bush Heritage Australia’s Hamelin Station, a relaxed setting on Malgana Country for knowledge sharing and storytelling. An inspirational weekend under the stars sowed the seeds for a partnership to heal Country. Our focus was on restoring seagrass, which grows in extensive meadows in shallow waters. In 2010-11, an extreme marine heatwave had hit the Western Australian coastline. The seagrass (wirriya jalyanu) was badly damaged. This affected the health of culturally significant species such as dugongs (Dugong dugon, wuthuga) and green turtles (Chelonia mydas, buyungurra), which feed on the seagrass. On that weekend in 2018, we (university researchers and Traditional Owners) learned we had a common goal: to look after Sea Country. Ecosystem restoration and biodiversity conservation are Western “science speak” and are part of a global solution to manage the impacts of climate change. These concepts are also at the core of Indigenous culture and lore. Our co-designed project won funding to employ Malgana land and sea rangers in Gathaagudu/Shark Bay, a UNESCO World Heritage area. The project was a partnership between the newly founded Malgana Aboriginal Corporation and University of Western Australia researchers. The aim was to develop and test ways to restore seagrass meadows, drawing on both Western science and Indigenous knowledge. Our new research paper describes how this partnership succeeded. Malgana land and sea rangers at Hamelin Station, Gathaagudu/Shark Bay, Western Australia. Elizabeth Sinclair, UWA, CC BY ‘Being on Country is medicine for us’ Our partnership recognised that Indigenous Peoples have deep ecological knowledge of Country. Malgana people shared their valuable insights on Sea Country. Storytelling or songlines demonstrate a long oral history and connection of Malgana people to their Country. The stories are consistent with Western science-based knowledge from diverse fields such as ecology, geology, hydrology and molecular biology. The partnership enabled trainee Indigenous rangers to return to Country. At the same time, they were able to gain industry qualifications through TAFE. Knowledge-sharing workshops on Country helped Malgana rangers connect or reconnect with Country. The workshops covered cultural protocols, Traditional ecological knowledge, Malgana language, seagrass growth, flowering and seeding ecology. Participants in the project meet on Country. Patricia Oakley, Malgana Elder We also undertook research to understand relatedness, or genetics, of two large seagrasses, wire weed (Amphibolis antarctica) and ribbon weed (Posidonia australis), across Gathaagudu. DNA testing has shown an ancient ribbon weed clone is the world’s largest plant, spanning at least 180 kilometres. Our genetic study of wire weed is not yet published. We developed restoration methods for both species. Our approaches took into account their different reproductive traits and genetic information. Our restoration methods included planting cuttings or runners, sowing seeds and modifying the environment by providing hessian substrate for seedlings to attach. Malgana ranger Nicholas Pedrocchi (deceased, published with the family’s permission) and UWA researcher John Statton lower a seagrass snagger, a sand-filled hessian sock, into the water. Elizabeth Sinclair, UWA, CC BY A Wirriya Jalyanu Festival marked the end of our project funding. Its theme was Art Meets Science. The festival shared knowledge of Sea Country through a mix of science, culture, language and artistic activities for all ages. Sharing this knowledge with the wider community improved their understanding of this World Heritage area. We came away with a deeper understanding of their love and shared responsibility for its care. ‘If we look after country, then Country will look after you’ Partnerships that share Western and Traditional knowledge can restore seagrass meadows. The methods need to be scaled up to heal Sea Country, given the scale of loss caused by a single extreme climate event. Local Indigenous ranger programs have environmental, cultural, social and economic benefits. Healing Country helps heal the intergenerational trauma of Indigenous Peoples through connecting or reconnecting to Country. A next step is to empower the Malgana rangers and local Indigenous-led businesses to support and monitor large-scale ecosystem restoration and its impacts on biodiversity. Continuous funding for these ranger programs is desperately needed to provide job security. Broadening partnerships with local rangers and communities allows for year-round observation and action On Country. Since Europeans colonised Australia, Indigenous Peoples have been disrespected, which has contributed to enormous damage to our unique wildlife and ecosystems. The dynamic nature of these problems means we need diverse knowledge inputs. Partnering with local Traditional Custodians for two-way learning is a respectful way forward. Western science and Traditional ecological knowledge together lead to a better understanding of Country. Applying these combined knowledges can increase biodiversity and help meet ambitious global solutions to climate change, such as the UN Decade on Ecosystem Restoration 2021-2030. Elizabeth Sinclair receives funding from the Australian Research Council. This project was supported with funding from the Australian government under the National Environmental Science Program (NESP) Marine Biodiversity Hub and Marine and Coastal Hub. Gary Kendrick receives funding from the Australian Research Council. This project was funded through the Australian government's National Environmental Science Program.Martin Breed receives funding from the Australian Research Council, National Environmental Science Program (NESP) Resilient Landscapes Hub, Cooperative Research Centre for Transformations in Mining Economies (CRC TiME), Australian Academy of Science, and the New Zealand Ministry of Business, Innovation & Employment. Patricia Oakley is a descendant of the Malgana saltwater people from Gathaagudu (Shark Bay) and member of the Malgana Aboriginal Corporation (MAC) and MAC Elders Advisory Council, a senior ranger and a director on the MAC and Department of Biodiversity Conservation and Attractions Joint Management Body. Sean McNeair works for Tidal Moon Pty Ltd and is a major shareholder since his resignation from Yamatji Marlpa Aboriginal Corporation (YMAC) as the MAC ranger co-ordinator (2018 to 2020). He is also affiliated with the Australian Marine Park Advisory Committee as a voluntary member and is a current official member of the Malgana Aboriginal Corporation (MAC) since native title determination in late 2018.

A partnership that combines Western science and Traditional Owners’ ecological knowledge is restoring the seagrass meadows of Gathaagudu/Shark Bay.

Community glass artwork by Shark Bay Arts Council members of restored seagrass meadow on display at the Wirriya Jalyanu (seagrass) Festival. Elizabeth Sinclair/UWA

Please be advised that the following article contains images of an Indigenous person who has died, which are used with family permission.

Our journey began in 2018 at Bush Heritage Australia’s Hamelin Station, a relaxed setting on Malgana Country for knowledge sharing and storytelling. An inspirational weekend under the stars sowed the seeds for a partnership to heal Country. Our focus was on restoring seagrass, which grows in extensive meadows in shallow waters.

In 2010-11, an extreme marine heatwave had hit the Western Australian coastline. The seagrass (wirriya jalyanu) was badly damaged. This affected the health of culturally significant species such as dugongs (Dugong dugon, wuthuga) and green turtles (Chelonia mydas, buyungurra), which feed on the seagrass.

On that weekend in 2018, we (university researchers and Traditional Owners) learned we had a common goal: to look after Sea Country. Ecosystem restoration and biodiversity conservation are Western “science speak” and are part of a global solution to manage the impacts of climate change. These concepts are also at the core of Indigenous culture and lore.

Our co-designed project won funding to employ Malgana land and sea rangers in Gathaagudu/Shark Bay, a UNESCO World Heritage area. The project was a partnership between the newly founded Malgana Aboriginal Corporation and University of Western Australia researchers. The aim was to develop and test ways to restore seagrass meadows, drawing on both Western science and Indigenous knowledge.

Our new research paper describes how this partnership succeeded.

Malgana land and sea rangers at Hamelin Station, Gathaagudu/Shark Bay, Western Australia. Elizabeth Sinclair, UWA, CC BY

‘Being on Country is medicine for us’

Our partnership recognised that Indigenous Peoples have deep ecological knowledge of Country. Malgana people shared their valuable insights on Sea Country.

Storytelling or songlines demonstrate a long oral history and connection of Malgana people to their Country. The stories are consistent with Western science-based knowledge from diverse fields such as ecology, geology, hydrology and molecular biology.

The partnership enabled trainee Indigenous rangers to return to Country. At the same time, they were able to gain industry qualifications through TAFE.

Knowledge-sharing workshops on Country helped Malgana rangers connect or reconnect with Country. The workshops covered cultural protocols, Traditional ecological knowledge, Malgana language, seagrass growth, flowering and seeding ecology.

Participants in the project meet on Country. Patricia Oakley, Malgana Elder

We also undertook research to understand relatedness, or genetics, of two large seagrasses, wire weed (Amphibolis antarctica) and ribbon weed (Posidonia australis), across Gathaagudu. DNA testing has shown an ancient ribbon weed clone is the world’s largest plant, spanning at least 180 kilometres. Our genetic study of wire weed is not yet published.

We developed restoration methods for both species. Our approaches took into account their different reproductive traits and genetic information.

Our restoration methods included planting cuttings or runners, sowing seeds and modifying the environment by providing hessian substrate for seedlings to attach.

Malgana ranger Nicholas Pedrocchi (deceased, published with the family’s permission) and UWA researcher John Statton lower a seagrass snagger, a sand-filled hessian sock, into the water. Elizabeth Sinclair, UWA, CC BY

A Wirriya Jalyanu Festival marked the end of our project funding. Its theme was Art Meets Science. The festival shared knowledge of Sea Country through a mix of science, culture, language and artistic activities for all ages.

Sharing this knowledge with the wider community improved their understanding of this World Heritage area. We came away with a deeper understanding of their love and shared responsibility for its care.

‘If we look after country, then Country will look after you’

Partnerships that share Western and Traditional knowledge can restore seagrass meadows. The methods need to be scaled up to heal Sea Country, given the scale of loss caused by a single extreme climate event.

Local Indigenous ranger programs have environmental, cultural, social and economic benefits. Healing Country helps heal the intergenerational trauma of Indigenous Peoples through connecting or reconnecting to Country.

A next step is to empower the Malgana rangers and local Indigenous-led businesses to support and monitor large-scale ecosystem restoration and its impacts on biodiversity.

Continuous funding for these ranger programs is desperately needed to provide job security. Broadening partnerships with local rangers and communities allows for year-round observation and action On Country.

Since Europeans colonised Australia, Indigenous Peoples have been disrespected, which has contributed to enormous damage to our unique wildlife and ecosystems. The dynamic nature of these problems means we need diverse knowledge inputs. Partnering with local Traditional Custodians for two-way learning is a respectful way forward.

Western science and Traditional ecological knowledge together lead to a better understanding of Country. Applying these combined knowledges can increase biodiversity and help meet ambitious global solutions to climate change, such as the UN Decade on Ecosystem Restoration 2021-2030.

The Conversation

Elizabeth Sinclair receives funding from the Australian Research Council. This project was supported with funding from the Australian government under the National Environmental Science Program (NESP) Marine Biodiversity Hub and Marine and Coastal Hub.

Gary Kendrick receives funding from the Australian Research Council. This project was funded through the Australian government's National Environmental Science Program.

Martin Breed receives funding from the Australian Research Council, National Environmental Science Program (NESP) Resilient Landscapes Hub, Cooperative Research Centre for Transformations in Mining Economies (CRC TiME), Australian Academy of Science, and the New Zealand Ministry of Business, Innovation & Employment.

Patricia Oakley is a descendant of the Malgana saltwater people from Gathaagudu (Shark Bay) and member of the Malgana Aboriginal Corporation (MAC) and MAC Elders Advisory Council, a senior ranger and a director on the MAC and Department of Biodiversity Conservation and Attractions Joint Management Body.

Sean McNeair works for Tidal Moon Pty Ltd and is a major shareholder since his resignation from Yamatji Marlpa Aboriginal Corporation (YMAC) as the MAC ranger co-ordinator (2018 to 2020). He is also affiliated with the Australian Marine Park Advisory Committee as a voluntary member and is a current official member of the Malgana Aboriginal Corporation (MAC) since native title determination in late 2018.

Read the full story here.
Photos courtesy of

New Biomarker Could Detect Alzheimer’s Years Before Symptoms Appear

TSPO levels rise early in Alzheimer’s and persist throughout disease. Targeting this biomarker could open new treatment options. TSPO, a major marker of brain inflammation, may offer a way to detect Alzheimer’s disease long before memory problems and other symptoms develop. Findings published in Acta Neuropathologica suggest it could transform both diagnosis and treatment strategies. [...]

A new study suggests that TSPO, a key biomarker of brain inflammation, may reveal the earliest stages of Alzheimer’s disease long before symptoms appear. Credit: StockTSPO levels rise early in Alzheimer’s and persist throughout disease. Targeting this biomarker could open new treatment options. TSPO, a major marker of brain inflammation, may offer a way to detect Alzheimer’s disease long before memory problems and other symptoms develop. Findings published in Acta Neuropathologica suggest it could transform both diagnosis and treatment strategies. “This is the first study to really examine how early this biomarker increases and where it begins rising in the brain,” said Tomás R. Guilarte, lead researcher and dean of FIU’s Robert Stempel College of Public Health & Social Work. “If we can use this information to help delay Alzheimer’s progression by even five years, it can drastically improve patients’ lives and reduce disease prevalence.” Longstanding research on TSPO Guilarte, a recognized authority on TSPO (translocator protein 18 kDa), has investigated the protein for more than 30 years. His research helped establish it as a dependable imaging marker for identifying neuroinflammation across multiple neurological, neurodegenerative, and psychiatric conditions. Researchers Daniel Martínez Pérez (L) and Dr. Tomás R. Guilarte (R) in the Brain, Behavior and the Environment Laboratory at Florida International University. Guilarte and Martínez Pérez published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International UniversityFor the current study, Guilarte and colleagues applied advanced imaging techniques to track TSPO activity in genetically engineered mouse models of familial Alzheimer’s. They then validated these results using donated brain tissue from members of the world’s largest community with early-onset familial Alzheimer’s, based in Antioquia, Colombia. These families carry the “paisa” mutation, first identified by the late Dr. Francisco Lopera, a co-author of the study who spent his career searching for ways to prevent Alzheimer’s. Individuals with this genetic variant often develop symptoms in their 30s or 40s and typically die in their 50s. L: The original cell image. R: The same cell image zoomed in and rendered in the special imaging software. Microglia (blue) signaling TSPO (red) are clustered around plaques (cyan). Researchers at Florida International University published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in.  Credit: Chris Necuze, Florida International UniversityEarly changes in the hippocampus In the mouse model, researchers detected elevated TSPO levels in the subiculum – a critical part of the hippocampus – as early as six weeks of age, roughly equivalent to age 18–20 in humans. Microglia, the brain’s main immune cells, specifically those clustered around amyloid plaques, had the highest levels of TSPO. Notably, female mice had higher TSPO levels, mirroring real-world statistics: two-thirds of Alzheimer’s patients are women. Daniel Martínez Pérez holds tissue sample. Martínez Pérez, a researcher in Florida International University’s Robert Stempel College of Public Health & Social Work, is the first author of a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International UniversityThe brain tissue samples from the Colombian patients with the paisa mutation showed the same pattern. Even in late-stage Alzheimer’s, TSPO remained high in microglia near plaques. These results raise new questions about TSPO’s function – whether it contributes to damage or protects the brain – and whether blocking or enhancing it could halt disease progression. Next steps in research The team is now working with a specially developed Alzheimer’s mouse model lacking TSPO to explore these questions further. They’re also expanding the study to include sporadic, late-onset Alzheimer’s cases, the form that accounts for over 90% of all diagnoses. Researchers Dr. Tomás R. Guilarte (L) and Daniel Martínez Pérez (R) in the Brain, Behavior and the Environment Laboratory at Florida International University. Guilarte and Martínez Pérez published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International University“The more we understand these processes,” said Daniel Martínez Pérez, first author and Ph.D. candidate in Guilarte’s lab, “the closer we get to tailoring treatments that can truly help – before it’s too late.” Reference: “Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer’s disease” by Daniel A. Martinez-Perez, Jennifer L. McGlothan, Alexander N. Rodichkin, Karam Abilmouna, Zoran Bursac, Francisco Lopera, Carlos Andres Villegas-Lanau and Tomás R. Guilarte, 17 July 2025, Acta Neuropathologica.DOI: 10.1007/s00401-025-02912-4 This work was supported by grants ES007062-24 to T.R.G. from the National Institute of Environmental Health Sciences (NIEHS), ES007062-23S1 to T.R.G. from the National Institute on Aging, and T32-ES033955 to A.N.R. from the NIEHS. Never miss a breakthrough: Join the SciTechDaily newsletter.

Living Near Polluted Missouri Creek as a Child Tied to Later Cancer Risk

By I. Edwards HealthDay ReporterTHURSDAY, July 17, 2025 (HealthDay News) — Folks who grew up near a polluted Missouri creek during the 1940s...

THURSDAY, July 17, 2025 (HealthDay News) — Folks who grew up near a polluted Missouri creek during the 1940s through 1960s may have higher odds for cancer now, new research shows.The study focused on Coldwater Creek in St. Louis County. The area was contaminated with radioactive waste from the U.S. government’s atomic bomb program during World War II.Back then, uranium was processed in St. Louis and nuclear waste was stored near the city’s airport. That waste leaked into Coldwater Creek, which runs through several residential neighborhoods.Researchers found that people who lived within one kilometer (0.62 miles) of the creek as kids had an 85% higher risk of developing certain cancers later in life compared to those who lived more than 20 kilometers (12.4 miles) away.Those cancers include leukemia, thyroid cancer and breast cancer, which are known to be linked to radiation exposure.“The closer the childhood residence got to Coldwater Creek, the risk of cancer went up, and pretty dramatically," lead researcher Marc Weisskopf, a professor of epidemiology at Harvard T.H. Chan School of Public Health, told The Wall Street Journal.For the study, Weisskopf’s team surveyed more than 4,200 adults who lived in the St. Louis area as children between 1958 and 1970.These people had donated their baby teeth years ago for radiation research. The new survey asked about cancer and other health issues.About 1 in 4 participants said they had been diagnosed with cancer. Risk dropped the farther someone lived from the creek as a child.Outside experts who reviewed the findings described them as concerning.“It emphasizes the importance of appreciating that radioactive waste is carcinogenic, particularly to children, and that we have to ensure that we have to clean up any remaining waste that’s out there,” Dr. Rebecca Smith-Bindman, a radiation risk expert at the University of California, San Francisco, told The Journal.In 2024, the U.S. Army Corps of Engineers began placing warning signs along parts of the creek that still have radioactive waste, The Journal reported.The U.S. Agency for Toxic Substances and Disease Registry reported in 2019 that contamination have raised the risk of leukemia and lung and bone cancer. Later exposures, starting in the 2000s, were linked to a slight increase in lung cancer for those who lived nearby.But the agency said it’s hard to link any one person’s cancer directly to radiation. Genetics, lifestyle and other factors could also play a role.In this study, radiation exposure wasn’t directly measured. Cancer cases were also self-reported, not confirmed by medical records. Weisskopf plans to measure radiation levels using the stored baby teeth in future research.Radiation exposure has long been tied to cancer, but this study is among the first to look at lower, long-term environmental exposure in the U.S., not just high levels from nuclear disasters or bombings."Radiation, when it’s given unnecessarily, only causes risk," Dr. Howard Sandler, chair of radiation oncology at Cedars-Sinai in Los Angeles, told The Journal.SOURCE: The Wall Street Journal, July 16, 2025Copyright © 2025 HealthDay. All rights reserved.

Disposable Vapes Release Toxic Metals, Lab Study Says

By Dennis Thompson HealthDay ReporterFRIDAY, July 11, 2025 (HealthDay News) — People using cheap disposable vape devices are likely inhaling high...

By Dennis Thompson HealthDay ReporterFRIDAY, July 11, 2025 (HealthDay News) — People using cheap disposable vape devices are likely inhaling high levels of toxic metals with every puff, a recent study says.After a few hundred puffs, some disposable vapes start releasing levels of toxic metals higher than found in either last-generation refillable e-cigarettes or traditional tobacco smokes, researchers reported in the journal ACS Central Science.These metals can increase a person’s risk of cancer, lung disease and nerve damage, researchers said.“Our study highlights the hidden risk of these new and popular disposable electronic cigarettes — with hazardous levels of neurotoxic lead and carcinogenic nickel and antimony — which stresses the need for urgency in enforcement,” senior researcher Brett Poulin, an assistant professor of environmental toxicology at the University of California-Davis, said in a news release.Earlier studies found that the heating elements of refillable vapes could release metals like chromium and nickel into the vapor people breathe.For this study, researchers analyzed seven disposable devices from three well-known vape brands: ELF Bars, Flum Pebbles and Esco Bar.Before they were even used, some of the devices had surprisingly high levels of lead and antimony, researchers reported. The lead appears to have come from leaded copper alloys used in the devices, which leach into the e-liquid.The team then activated the disposable vapes, creating between 500 and 1,500 puffs for each device, to see whether their heating elements would release more metals.Analysis of the vapor revealed that:Levels of metals like chromium, nickel and antimony increased as the number of puffs increased, while concentrations of zinc, copper and lead were elevated at the start. Most of the tested disposables released higher amounts of metals than older refillable vapes. One disposable released more lead during a day’s use than one would get from nearly 20 packs of tobacco cigarettes. Nickel in three devices and antimony in two devices exceeded cancer risk limits. Four devices had nickel and lead emissions that surpassed health risk thresholds for diseases other than cancer. These results reflect only three of the nearly 100 disposable vape brands now available on store shelves, researchers noted.“Coupling the high element exposures and health risks associated with these devices and their prevalent use among the underage population, there is an urgent need for regulators to investigate this issue further and exercise regulatory enforcement accordingly,” researchers wrote.SOURCES: American Chemical Society, news release, June 20, 2025; ACS Central Science, June 25, 2025Copyright © 2025 HealthDay. All rights reserved.

Trying to Quit Smoking? These Expert-Backed Tips Can Help

By David Hill, MD, Chair, Board of Directors, American Lung Association HealthDay ReporterTHURSDAY, July 10, 2025 (HealthDay News) — According to...

THURSDAY, July 10, 2025 (HealthDay News) — According to the U.S. Centers for Disease Control and Prevention (CDC), in 2022, the majority of the 28.8 million U.S. adults who smoked cigarettes wanted to quit; approximately half had tried to quit, but fewer than 10% were successful.Many folks say quitting smoking was the hardest thing they have ever done. This includes people who have climbed mountains, corporate ladders, tackled childbirth and raised families.Successfully overcoming tobacco addiction is a process, and it takes time. It can’t be done at once. Individuals taught themselves how to smoke, vape or chew tobacco products and practiced for so long that the behavior became as automatic as breathing, eating or sleeping.Quitting, then, is a process of overcoming addiction and learned behaviors. Individuals must learn to manage nicotine addiction, unlearn their automatic behavior of tobacco use, and replace it with healthy new alternatives.Because tobacco dependence is a chronic relapsing condition, Freedom From Smoking® identifies quitting tobacco use and maintaining abstinence as a process in which a person may cycle through multiple periods of relapse and remission before experiencing long-term lifestyle and behavior change.The CDC suggests that it takes eight to 11 attempts before quitting permanently.It’s essential to understand three challenges associated with quitting and create a plan to address each with proven-effective strategies:1. Psychological Link of Nicotine Addiction Over time, using tobacco products becomes an automatic behavior that needs to be unlearned.  After quitting, emotions can overwhelm a person.  Grief can also play an important role in the quitting process.  Create support systems through counseling classes, and among family, friends and co-workers. Mark a calendar for every day you are tobacco-free and reward yourself for days you avoid use. Use positive self-talk when cravings arise, such as “the urge will pass whether I smoke or not” or “smoking is not an option for me.”2. Sociocultural Link of Nicotine AddictionCertain activities and environmental cues can trigger the urge to smoke. As people mature, social factors or cues play a role in continuing use.  People who use tobacco may be reluctant to give up those connections or routines.  Identify your triggers and use replacements such as cinnamon sticks, doodling on a notepad or finding another activity to keep your hands busy. Create change and break routine by using the 3 A’s — AVOID (the situation), ALTER (the situation) or ALTERNATIVE (substitute something else). Keep a quit kit/survival kit with you at all times with items you can use to replace tobacco product use when the urge comes.3. Biological (Physical) Link of Nicotine AddictionAddiction occurs when a substance — like nicotine, alcohol or cocaine — enters the brain and activates the brain’s receptors for that substance, producing pleasure.  When a person quits, the brain’s nicotine receptors activate, creating cravings and withdrawal symptoms.  Over time, the receptors become inactive, and the withdrawal symptoms and urges to use fade away. Use cessation medications approved by the U.S. Food and Drug Administration (prescription or over-the-counter) in the proper doses for the full time period recommended by a clinician. Do not stop treatment early. Exercise alternative ways to release dopamine such as physical activity or listening to music.  Use stress management techniques, including deep breathing and relaxation exercises, daily if possible.Nearly 2 in 3 adults who have ever smoked cigarettes have successfully quit, according to the CDC You can, too! To learn more about strategies for countering the challenges associated with the three-link chain of nicotine addiction, visit Quit Smoking & Vaping | American Lung Association.Dr. David Hill is a member of the Lung Association's National Board of Directors and is the immediate past chair of the Northeast Regional Board of the American Lung Association. He serves on the Leadership Board of the American Lung Association in Connecticut and is a former chair of that board. He is a practicing pulmonary and critical care physician with Waterbury Pulmonary Associates and serves as their director of clinical research. He is an assistant clinical professor of medicine at the Yale University School of Medicine, an assistant clinical professor at the Frank Netter School of Medicine at Quinnipiac University, and a clinical instructor at the University of Connecticut School of Medicine.Copyright © 2025 HealthDay. All rights reserved.

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