Cookies help us run our site more efficiently.

By clicking “Accept”, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. View our Privacy Policy for more information or to customize your cookie preferences.

The youth mental health crisis is hitting LGBTQ+ teens hardest

News Feed
Wednesday, August 14, 2024

People raise pride flags to support the book Gender Queer, a graphic novel about a nonbinary teen, at a school board meeting in 2022. | H. Rick Bamman/Pioneer Press/Chicago Tribune/Tribune News Service via Getty Images Last week, the Centers for Disease Control and Prevention (CDC) released a report on their 2023 Youth Risk Behavior Survey (YRBS). The report includes data on a wide range of health-related behaviors of high school students in the United States, and breaks down these behaviors across different demographics. The results underscore the fact that we’re in the middle of a youth mental health crisis that has been steadily worsening for years — one that is particularly acute for LGBTQ+ youth.  According to the report, 41 percent of LGBTQ+ teens seriously considered suicide during the previous 12 months, 32 percent made a plan to do so, and 20 percent attempted to end their own life. By comparison, 13 percent of cisgender and heterosexual students seriously considered suicide, 11 percent made a plan, and 6 percent attempted suicide.  While LGBTQ+ representation and rights have improved in the last few decades, large swaths of queer and trans kids are still living in an environment that is deeply hostile to their very existence. There’s a long and ongoing conservative culture war that aims to reverse what progress has been made in recent years for the LGBTQ+ community, culminating in legislation and policies that harm LGBTQ+ youth, like restricting gender-affirming health care, forcing schools to out queer and trans students to their parents, and banning books that have LGBTQ+ content.  To understand how we can help bring down these stark mental health disparities for LGBTQ+ teens, it’s critical that we first look at the overall youth mental health crisis, and the unique challenge that LGBTQ+ teens are facing on top of it. The state of youth mental health It’s never been easy to be a teenager, but today’s youth are clearly facing a mental health crisis. Suicide is one of the leading causes of death for teens in the United States. They’re more depressed and anxious. And it’s only been getting worse since the early 2010s. For the 2023 report, which is conducted every other year, over 20,000 questionnaires were filled out by students from 155 schools across the US. The CDC researchers found that while some improvements have been made for youth health and well-being, largely all other mental health indicators worsened. We shouldn’t overlook the small glimmers of hope, though. Hispanic youth who made a plan to kill themselves dropped from 19 percent in 2021 to 16 percent in 2023. And in that same time period, Black students who attempted suicide dropped from 14 percent to 10 percent. Worried about a child or teen’s mental well-being? Here are some online resources to learn more about symptoms, treatment strategies, and how to help. Effective Child Therapy is a resource from the Society of Clinical Child and Adolescent Psychology. The website has information on the emotional concerns, symptoms, and disorders that commonly impact teens (divorce, bullying, body image, anxiety, depression, and more) — and the evidence-based therapies that can help. The American Academy of Child and Adolescent Psychiatry has information for parents on how to spot symptoms of mental health issues, and where to seek help. The Clay Center for Young Healthy Minds has educational articles on mental health issues, as well as many links for where to turn when searching for particular support groups, programs, and therapies. The Crisis Text Line is a text messaging-based service for people enduring “any type of crisis.” And the National Suicide Prevention Lifeline is a phone-based service. The Trevor Project is a crisis helpline for LGBTQ+ youth. It can be reached at 1-866-488-7386. But for LGBTQ+ youth — which the report indicated had higher rates of suicidality than all other groups —  there just isn’t enough comparable data yet to show a trend over time in the YRBS. 2015 was the first year that the CDC started measuring sexuality as a demographic, but it only included lesbian, gay, and bisexual as options to pick from. In 2021, they adjusted that to include students who were questioning their sexuality. Only this most recent report now includes transgender students. Because of these changes in measurement, it will take years for us to get a more accurate picture of how LGBTQ+ mental health is faring.  And while the report gives us a lot of helpful information, it doesn’t give us data for youth who hold multiple identities, like LGBTQ+ youth of color — who face unique challenges of their own.     “Queer youth of color, trans youth of color, are dealing with stigma tied to not just being queer and youth of color, but also the intersecting stigma of both,” said Allen Mallory, an assistant professor of human development at Ohio State University. Navigating the intersection of these identities can be stressors for LGBTQ+ teens of color, Mallory says. There is no one singular force to blame for why teens are suffering from poor mental health and suicidal thoughts, but researchers have some hypotheses. A big debate in youth mental health is the use of social media and smartphones, with some researchers pointing to these digital tools as a major driver in worsening trends. But other experts argue that phones and social media are not the driving force behind declining mental health for youth — and have pointed out that for kids who lack connection in real life, finding community online is a real solace. The developmental collision It might seem surprising that LGBTQ+ youth mental health appears to be worsening even as the social atmosphere on LGBTQ+ rights has largely improved in recent decades. So why hasn’t that translated to improved mental health? The apparent paradox may have an explanation. Broader acceptance of LGBTQ+ people has allowed for more visibility and for people to come out as queer or trans at younger ages. That means instead of coming out as a young adult or even later on, kids are coming out in early adolescence.  But that particular period of human development — being a teenager — is a heightened time of self-consciousness and peer regulation, especially for precisely those younger teens who are also in the process of coming out. Stephen Russell, a professor and director of University of Texas at Austin’s School of Human Ecology, calls this “developmental collision.” “Kids are coming out right at this time that, developmentally, is the most they’re most attuned to regulating each other,” says Russell. For LGBTQ+ youth, this period of peer regulation can mean facing bullying and discrimination from their classmates on the basis of their sexuality or gender — a unique challenge that comes on top of typical teenage challenges. (Staying in the closet isn’t a solution, either. Kids deserve to be their authentic selves, not shamed into hiding.) “The dynamic of coming out at a younger age in these times elicits and invites and creates the possibility for wonderful things, but also for stigma and other kinds of vulnerability,” he added.  Other bigger, structural and environmental issues play a part in this mental health crisis. From climate change to growing gun violence, finding safety and stability — crucial for mental and physical well-being — has taken a toll. The Covid-19 pandemic, in which over 200,000 kids under 18 lost a parent or caregiver as of 2022, can’t be ruled out either. And a culture war on “wokeness,” raised by conservative politicians and pundits, has aimed to reinvigorate animosity toward youth of color and LGBTQ+ teens. To be clear, the fault is not on these teenagers for going through basic developmental periods, or for being LGBTQ+, or for struggling with big issues. What it does mean is that LGBTQ+ youth are facing unique challenges that must be recognized when creating and implementing interventions for their mental health. How to help LGBTQ+ youth The field of LGBTQ+ youth mental health is still evolving, and along with it, how to approach the subject from a clinical and public health perspective. But there are a lot of promising interventions to tackle this crisis. From a more macro perspective, implementing practices that reach people in their day-to-day life is key. For teens, a big part of everyday life involves school. One simple (and almost painfully obvious) practice to start with is inclusive, enumerated policies for LGBTQ+ youth — basically, protection from bullying and discrimination. “These policies we see at the state and school district level have really big implications for how LGBTQ youth experience school in their day to day life,” said Jessica Fish, an associate professor and the director of the Sexual Orientation, Gender Identity, and Health Research Group at University of Maryland’s School of Public Health. Multiple studies have shown that LGBTQ+ students at schools with inclusive, enumerated policies experience less victimization and bullying — two things that can really impact a kid’s mental health. But according to the Movement Advancement Project, a nonprofit think tank focused on equality and democracy, 53 percent of LGBTQ+ people live in a state with no law protecting LGBTQ+ students from bullying in school, and 42 percent live in a state with no law protecting these teens from discrimination. If tackling state law feels too big, starting with an individual school community can work too. Take gender and sexuality alliances (GSAs, formerly known as gay-straight alliances). They’re student-led clubs that give LGBTQ+ and allied students a way to connect, support one another, and learn from each other. All of the public health experts I spoke to brought up GSAs — and there’s a lot of strong evidence that shows these groups can create a safer school climate and lower the risk of suicide and depression. While researchers have a lot of good information on what’s working for improving the mental health of LGBTQ+ youth, there’s still a lot of room for more data. This is especially true when it comes to understanding what works for trans youth and LGBTQ+ youth of color.  It’s also important to note that while there is absolutely a mental health crisis for LGBTQ+ youth, many go on to become content, productive adults. It’s not their identity that sentences them to depression or suicide — it’s the stigma and discrimination they face in their homes, schools, and institutions, at a time when their age makes them deeply vulnerable and reliant on their surroundings. There are many barriers to getting clinical help or implementing measures in schools. Understandably, that can feel like an uphill battle for LGBTQ+ youth and their families. But nothing is impossible, says Fish. “These are things that will take mobilization, that will take a large degree of advocacy and grassroots support within the community,” she told me. “So I do think all of these are possible, but I think it’s just trying to figure out where the vantage point for change is.” A version of this story originally appeared in the Future Perfect newsletter. Sign up here!

Last week, the Centers for Disease Control and Prevention (CDC) released a report on their 2023 Youth Risk Behavior Survey (YRBS). The report includes data on a wide range of health-related behaviors of high school students in the United States, and breaks down these behaviors across different demographics. The results underscore the fact that we’re […]

A hand raising the Philadelphia Pride Flag and the Rainbow Pride Flag. In the background is a classroom full of adults.
People raise pride flags to support the book Gender Queer, a graphic novel about a nonbinary teen, at a school board meeting in 2022. | H. Rick Bamman/Pioneer Press/Chicago Tribune/Tribune News Service via Getty Images

Last week, the Centers for Disease Control and Prevention (CDC) released a report on their 2023 Youth Risk Behavior Survey (YRBS). The report includes data on a wide range of health-related behaviors of high school students in the United States, and breaks down these behaviors across different demographics. The results underscore the fact that we’re in the middle of a youth mental health crisis that has been steadily worsening for years — one that is particularly acute for LGBTQ+ youth. 

According to the report, 41 percent of LGBTQ+ teens seriously considered suicide during the previous 12 months, 32 percent made a plan to do so, and 20 percent attempted to end their own life. By comparison, 13 percent of cisgender and heterosexual students seriously considered suicide, 11 percent made a plan, and 6 percent attempted suicide. 

While LGBTQ+ representation and rights have improved in the last few decades, large swaths of queer and trans kids are still living in an environment that is deeply hostile to their very existence. There’s a long and ongoing conservative culture war that aims to reverse what progress has been made in recent years for the LGBTQ+ community, culminating in legislation and policies that harm LGBTQ+ youth, like restricting gender-affirming health care, forcing schools to out queer and trans students to their parents, and banning books that have LGBTQ+ content. 

To understand how we can help bring down these stark mental health disparities for LGBTQ+ teens, it’s critical that we first look at the overall youth mental health crisis, and the unique challenge that LGBTQ+ teens are facing on top of it.

The state of youth mental health

It’s never been easy to be a teenager, but today’s youth are clearly facing a mental health crisis. Suicide is one of the leading causes of death for teens in the United States. They’re more depressed and anxious. And it’s only been getting worse since the early 2010s.

For the 2023 report, which is conducted every other year, over 20,000 questionnaires were filled out by students from 155 schools across the US. The CDC researchers found that while some improvements have been made for youth health and well-being, largely all other mental health indicators worsened.

We shouldn’t overlook the small glimmers of hope, though. Hispanic youth who made a plan to kill themselves dropped from 19 percent in 2021 to 16 percent in 2023. And in that same time period, Black students who attempted suicide dropped from 14 percent to 10 percent.

Worried about a child or teen’s mental well-being? Here are some online resources to learn more about symptoms, treatment strategies, and how to help.

But for LGBTQ+ youth — which the report indicated had higher rates of suicidality than all other groups —  there just isn’t enough comparable data yet to show a trend over time in the YRBS. 2015 was the first year that the CDC started measuring sexuality as a demographic, but it only included lesbian, gay, and bisexual as options to pick from. In 2021, they adjusted that to include students who were questioning their sexuality. Only this most recent report now includes transgender students. Because of these changes in measurement, it will take years for us to get a more accurate picture of how LGBTQ+ mental health is faring. 

And while the report gives us a lot of helpful information, it doesn’t give us data for youth who hold multiple identities, like LGBTQ+ youth of color — who face unique challenges of their own.    

“Queer youth of color, trans youth of color, are dealing with stigma tied to not just being queer and youth of color, but also the intersecting stigma of both,” said Allen Mallory, an assistant professor of human development at Ohio State University. Navigating the intersection of these identities can be stressors for LGBTQ+ teens of color, Mallory says.

There is no one singular force to blame for why teens are suffering from poor mental health and suicidal thoughts, but researchers have some hypotheses. A big debate in youth mental health is the use of social media and smartphones, with some researchers pointing to these digital tools as a major driver in worsening trends. But other experts argue that phones and social media are not the driving force behind declining mental health for youth — and have pointed out that for kids who lack connection in real life, finding community online is a real solace.

The developmental collision

It might seem surprising that LGBTQ+ youth mental health appears to be worsening even as the social atmosphere on LGBTQ+ rights has largely improved in recent decades. So why hasn’t that translated to improved mental health?

The apparent paradox may have an explanation. Broader acceptance of LGBTQ+ people has allowed for more visibility and for people to come out as queer or trans at younger ages. That means instead of coming out as a young adult or even later on, kids are coming out in early adolescence. 

But that particular period of human development — being a teenager — is a heightened time of self-consciousness and peer regulation, especially for precisely those younger teens who are also in the process of coming out. Stephen Russell, a professor and director of University of Texas at Austin’s School of Human Ecology, calls this “developmental collision.”

“Kids are coming out right at this time that, developmentally, is the most they’re most attuned to regulating each other,” says Russell. For LGBTQ+ youth, this period of peer regulation can mean facing bullying and discrimination from their classmates on the basis of their sexuality or gender — a unique challenge that comes on top of typical teenage challenges. (Staying in the closet isn’t a solution, either. Kids deserve to be their authentic selves, not shamed into hiding.)

“The dynamic of coming out at a younger age in these times elicits and invites and creates the possibility for wonderful things, but also for stigma and other kinds of vulnerability,” he added. 

Other bigger, structural and environmental issues play a part in this mental health crisis. From climate change to growing gun violence, finding safety and stability — crucial for mental and physical well-being — has taken a toll. The Covid-19 pandemic, in which over 200,000 kids under 18 lost a parent or caregiver as of 2022, can’t be ruled out either. And a culture war on “wokeness,” raised by conservative politicians and pundits, has aimed to reinvigorate animosity toward youth of color and LGBTQ+ teens.

To be clear, the fault is not on these teenagers for going through basic developmental periods, or for being LGBTQ+, or for struggling with big issues. What it does mean is that LGBTQ+ youth are facing unique challenges that must be recognized when creating and implementing interventions for their mental health.

How to help LGBTQ+ youth

The field of LGBTQ+ youth mental health is still evolving, and along with it, how to approach the subject from a clinical and public health perspective. But there are a lot of promising interventions to tackle this crisis.

From a more macro perspective, implementing practices that reach people in their day-to-day life is key. For teens, a big part of everyday life involves school. One simple (and almost painfully obvious) practice to start with is inclusive, enumerated policies for LGBTQ+ youth — basically, protection from bullying and discrimination.

“These policies we see at the state and school district level have really big implications for how LGBTQ youth experience school in their day to day life,” said Jessica Fish, an associate professor and the director of the Sexual Orientation, Gender Identity, and Health Research Group at University of Maryland’s School of Public Health.

Multiple studies have shown that LGBTQ+ students at schools with inclusive, enumerated policies experience less victimization and bullying — two things that can really impact a kid’s mental health. But according to the Movement Advancement Project, a nonprofit think tank focused on equality and democracy, 53 percent of LGBTQ+ people live in a state with no law protecting LGBTQ+ students from bullying in school, and 42 percent live in a state with no law protecting these teens from discrimination.

If tackling state law feels too big, starting with an individual school community can work too. Take gender and sexuality alliances (GSAs, formerly known as gay-straight alliances). They’re student-led clubs that give LGBTQ+ and allied students a way to connect, support one another, and learn from each other. All of the public health experts I spoke to brought up GSAs — and there’s a lot of strong evidence that shows these groups can create a safer school climate and lower the risk of suicide and depression.

While researchers have a lot of good information on what’s working for improving the mental health of LGBTQ+ youth, there’s still a lot of room for more data. This is especially true when it comes to understanding what works for trans youth and LGBTQ+ youth of color. 

It’s also important to note that while there is absolutely a mental health crisis for LGBTQ+ youth, many go on to become content, productive adults. It’s not their identity that sentences them to depression or suicide — it’s the stigma and discrimination they face in their homes, schools, and institutions, at a time when their age makes them deeply vulnerable and reliant on their surroundings.

There are many barriers to getting clinical help or implementing measures in schools. Understandably, that can feel like an uphill battle for LGBTQ+ youth and their families. But nothing is impossible, says Fish.

“These are things that will take mobilization, that will take a large degree of advocacy and grassroots support within the community,” she told me. “So I do think all of these are possible, but I think it’s just trying to figure out where the vantage point for change is.”

A version of this story originally appeared in the Future Perfect newsletter. Sign up here!

Read the full story here.
Photos courtesy of

Gas stove makers quietly delete air pollution warnings as they fight mandatory health labels

Manufacturers sued to stop a Colorado law requiring air quality warnings, arguing gas stoves are safe. Some of their websites once said the opposite.

The home appliance industry would like you to believe that gas-burning stoves are not a risk to your health — and several companies that make the devices are scrambling to erase their prior acknowledgements that they are.  That claim is at the heart of a lawsuit the Association of Home Appliance Manufacturers has filed against the state of Colorado to stop it from requiring natural gas stoves, which burn methane, to carry health labels not unlike those on every pack of cigarettes. “Understand the air quality implications of having an indoor gas stove,” the warning would read. The law was to take effect August 5 but is now on hold, and state officials did not respond to a request for comment. In its federal lawsuit, the Association — whose board includes representatives of LG Electronics, BSH Home Appliance Corp. (which makes Bosch appliances), Whirlpool, and Samsung Electronics — asserts that the labeling requirement is “unconstitutional compelled speech” and illegal under the First Amendment. It calls the legislation a climate law disguised as a health law and, most strikingly, it claims there is “no association between gas stoves and adverse health outcomes.”  Yet LG, BSH, Whirlpool, and Samsung have published information on their websites directly contradicting that claim and lauded the health benefits of electric and induction stoves.  “Traditional gas appliances can emit harmful pollutants, which can compromise indoor air quality and pose health risks,” reads a blog post, titled “Life’s Good When It’s Electrified,” that LG published in May of 2024. “By switching to electric appliances, these risks are substantially reduced, ensuring a cleaner and safer home environment.”  Another LG page noted that “induction surfaces remain cool to the touch and unlike gas, is better for kitchen air quality” as recently as May 25, according to an archived version of the site maintained by Wayback Machine. It was later revised to eliminate mention of gas, reading “Surfaces remain cool to the touch — no open flames or hot coils. No fumes, either, so it’s [sic] air quality-friendly.” BSH’s page on Bosch induction cooktops notes that the devices are “safer to use because unlike other types of cooktops, they do not release indoor air pollutants during cooking.” Whirlpool wrote that induction cooktops might help “reduce indoor air pollutants.”  And until last week, a page on Samsung’s U.S. website said “induction cooktops can … help remove concerns over indoor air pollution, creating a sustainable and healthier home environment. The page’s source code did not appear to have been updated since 2022. Samsung did not respond to multiple requests for comment, but the page was taken down shortly after Grist reached out to the company.  Itai Vardi, a researcher with the Energy and Policy Institute, was the first to notice the discrepancies between what the Association said in its lawsuit and what some of its manufacturers have said in the past. “The statements coming from them directly contradict the very strong language in this lawsuit,” Vardi said. “And that, I think, deserves some scrutiny.” Scientific evidence that gas stoves pollute by releasing dangerous concentrations of nitrogen dioxide, benzene, and methane has accumulated since 1970. Justin Paget / Getty Images In its lawsuit, the Association argues that “the potential health risks of cooking with gas are no different than cooking with electricity” and acknowledging the ways gas-burning appliances can harm respiratory health promotes “non-consensus, scientifically controversial, and factually misleading” messages. It adds that “there is scant scientific support” for disclosing health risks associated with gas appliances.  Asked for comment, the organization referred to a statement it issued August 6 saying “no study has found that gas stoves cause respiratory health issues.”  When reached for comment, a BSH representative stated that the company is as of now “in complete alignment” with the Association’s position. An LG representative noted that the most pollution-acknowledging statements on their website were in fact made by the company’s UK branch, but did not respond to a follow-up question about whether the UK and US divisions disagree on the risks of LG products. “This is a troubling attempt by these companies’ to quickly erase their own public acknowledgement of the dangers of gas stoves,” said Vardi. “But you can scrub your website, not the fact of gas stove pollution.”  Scientific evidence that gas stoves pollute by releasing dangerous concentrations of nitrogen dioxide, benzene, and methane has piled up for the past half-century. In 1970, scientist Carl Shy showed that families exposed to high levels of nitrogen dioxide indoors are at greater risk of asthma and other respiratory illnesses than those who are not. Nine years later, scientist Bernard Goldstein identified the fuel as the likely source of all that nitrogen. A bevy of studies and papers in the decades since came to similar conclusions. One 2022 study estimated that 12 percent of American children with asthma develop that respiratory condition solely due to living in homes with gas stoves.  Appliance manufacturers and the natural gas industry are no stranger to promoting their products regardless of known health risks. “There’s been a campaign by industry to keep the science under wraps or to confuse it, deny it,” said Abe Scarr of the consumer-protection nonprofit Public Interest Working Group.  The lobbyists at the American Gas Association have worked hard to popularize gas stoves: At one point, the organization even provided the stoves Julia Child used in her popular cooking show. The campaign went beyond product placement: When information on the health risks of gas stoves began to emerge in the mid-1970s, industry lobbyists launched “Operation Attack,” a million-dollar marketing campaign to bring the stoves into even more kitchens. This worked: today, about 40% of Americans cook with gas. They also funded their own research, which cast doubt on independent findings on the health risks of gas stoves.  Environmental health sciences professor Misbath Daouda of the University of California, Berkeley, was recently part of a pilot study replacing gas stoves in low-income New York City apartments with induction stoves. Nitrogen dioxide concentrations in those apartments, she said, dropped by over 50 percent within months – and the families who lived there liked their new cooktops better than the old ones, she said.  The association between gas stoves and adverse health outcomes, Daouda said, “is clear.”  “I’m not sure who they are referring to when they say the majority of studies” don’t support that conclusion, she said. This story was originally published by Grist with the headline Gas stove makers quietly delete air pollution warnings as they fight mandatory health labels on Sep 17, 2025.

New Biomarker Could Detect Alzheimer’s Years Before Symptoms Appear

TSPO levels rise early in Alzheimer’s and persist throughout disease. Targeting this biomarker could open new treatment options. TSPO, a major marker of brain inflammation, may offer a way to detect Alzheimer’s disease long before memory problems and other symptoms develop. Findings published in Acta Neuropathologica suggest it could transform both diagnosis and treatment strategies. [...]

A new study suggests that TSPO, a key biomarker of brain inflammation, may reveal the earliest stages of Alzheimer’s disease long before symptoms appear. Credit: StockTSPO levels rise early in Alzheimer’s and persist throughout disease. Targeting this biomarker could open new treatment options. TSPO, a major marker of brain inflammation, may offer a way to detect Alzheimer’s disease long before memory problems and other symptoms develop. Findings published in Acta Neuropathologica suggest it could transform both diagnosis and treatment strategies. “This is the first study to really examine how early this biomarker increases and where it begins rising in the brain,” said Tomás R. Guilarte, lead researcher and dean of FIU’s Robert Stempel College of Public Health & Social Work. “If we can use this information to help delay Alzheimer’s progression by even five years, it can drastically improve patients’ lives and reduce disease prevalence.” Longstanding research on TSPO Guilarte, a recognized authority on TSPO (translocator protein 18 kDa), has investigated the protein for more than 30 years. His research helped establish it as a dependable imaging marker for identifying neuroinflammation across multiple neurological, neurodegenerative, and psychiatric conditions. Researchers Daniel Martínez Pérez (L) and Dr. Tomás R. Guilarte (R) in the Brain, Behavior and the Environment Laboratory at Florida International University. Guilarte and Martínez Pérez published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International UniversityFor the current study, Guilarte and colleagues applied advanced imaging techniques to track TSPO activity in genetically engineered mouse models of familial Alzheimer’s. They then validated these results using donated brain tissue from members of the world’s largest community with early-onset familial Alzheimer’s, based in Antioquia, Colombia. These families carry the “paisa” mutation, first identified by the late Dr. Francisco Lopera, a co-author of the study who spent his career searching for ways to prevent Alzheimer’s. Individuals with this genetic variant often develop symptoms in their 30s or 40s and typically die in their 50s. L: The original cell image. R: The same cell image zoomed in and rendered in the special imaging software. Microglia (blue) signaling TSPO (red) are clustered around plaques (cyan). Researchers at Florida International University published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in.  Credit: Chris Necuze, Florida International UniversityEarly changes in the hippocampus In the mouse model, researchers detected elevated TSPO levels in the subiculum – a critical part of the hippocampus – as early as six weeks of age, roughly equivalent to age 18–20 in humans. Microglia, the brain’s main immune cells, specifically those clustered around amyloid plaques, had the highest levels of TSPO. Notably, female mice had higher TSPO levels, mirroring real-world statistics: two-thirds of Alzheimer’s patients are women. Daniel Martínez Pérez holds tissue sample. Martínez Pérez, a researcher in Florida International University’s Robert Stempel College of Public Health & Social Work, is the first author of a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International UniversityThe brain tissue samples from the Colombian patients with the paisa mutation showed the same pattern. Even in late-stage Alzheimer’s, TSPO remained high in microglia near plaques. These results raise new questions about TSPO’s function – whether it contributes to damage or protects the brain – and whether blocking or enhancing it could halt disease progression. Next steps in research The team is now working with a specially developed Alzheimer’s mouse model lacking TSPO to explore these questions further. They’re also expanding the study to include sporadic, late-onset Alzheimer’s cases, the form that accounts for over 90% of all diagnoses. Researchers Dr. Tomás R. Guilarte (L) and Daniel Martínez Pérez (R) in the Brain, Behavior and the Environment Laboratory at Florida International University. Guilarte and Martínez Pérez published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International University“The more we understand these processes,” said Daniel Martínez Pérez, first author and Ph.D. candidate in Guilarte’s lab, “the closer we get to tailoring treatments that can truly help – before it’s too late.” Reference: “Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer’s disease” by Daniel A. Martinez-Perez, Jennifer L. McGlothan, Alexander N. Rodichkin, Karam Abilmouna, Zoran Bursac, Francisco Lopera, Carlos Andres Villegas-Lanau and Tomás R. Guilarte, 17 July 2025, Acta Neuropathologica.DOI: 10.1007/s00401-025-02912-4 This work was supported by grants ES007062-24 to T.R.G. from the National Institute of Environmental Health Sciences (NIEHS), ES007062-23S1 to T.R.G. from the National Institute on Aging, and T32-ES033955 to A.N.R. from the NIEHS. Never miss a breakthrough: Join the SciTechDaily newsletter.

Living Near Polluted Missouri Creek as a Child Tied to Later Cancer Risk

By I. Edwards HealthDay ReporterTHURSDAY, July 17, 2025 (HealthDay News) — Folks who grew up near a polluted Missouri creek during the 1940s...

THURSDAY, July 17, 2025 (HealthDay News) — Folks who grew up near a polluted Missouri creek during the 1940s through 1960s may have higher odds for cancer now, new research shows.The study focused on Coldwater Creek in St. Louis County. The area was contaminated with radioactive waste from the U.S. government’s atomic bomb program during World War II.Back then, uranium was processed in St. Louis and nuclear waste was stored near the city’s airport. That waste leaked into Coldwater Creek, which runs through several residential neighborhoods.Researchers found that people who lived within one kilometer (0.62 miles) of the creek as kids had an 85% higher risk of developing certain cancers later in life compared to those who lived more than 20 kilometers (12.4 miles) away.Those cancers include leukemia, thyroid cancer and breast cancer, which are known to be linked to radiation exposure.“The closer the childhood residence got to Coldwater Creek, the risk of cancer went up, and pretty dramatically," lead researcher Marc Weisskopf, a professor of epidemiology at Harvard T.H. Chan School of Public Health, told The Wall Street Journal.For the study, Weisskopf’s team surveyed more than 4,200 adults who lived in the St. Louis area as children between 1958 and 1970.These people had donated their baby teeth years ago for radiation research. The new survey asked about cancer and other health issues.About 1 in 4 participants said they had been diagnosed with cancer. Risk dropped the farther someone lived from the creek as a child.Outside experts who reviewed the findings described them as concerning.“It emphasizes the importance of appreciating that radioactive waste is carcinogenic, particularly to children, and that we have to ensure that we have to clean up any remaining waste that’s out there,” Dr. Rebecca Smith-Bindman, a radiation risk expert at the University of California, San Francisco, told The Journal.In 2024, the U.S. Army Corps of Engineers began placing warning signs along parts of the creek that still have radioactive waste, The Journal reported.The U.S. Agency for Toxic Substances and Disease Registry reported in 2019 that contamination have raised the risk of leukemia and lung and bone cancer. Later exposures, starting in the 2000s, were linked to a slight increase in lung cancer for those who lived nearby.But the agency said it’s hard to link any one person’s cancer directly to radiation. Genetics, lifestyle and other factors could also play a role.In this study, radiation exposure wasn’t directly measured. Cancer cases were also self-reported, not confirmed by medical records. Weisskopf plans to measure radiation levels using the stored baby teeth in future research.Radiation exposure has long been tied to cancer, but this study is among the first to look at lower, long-term environmental exposure in the U.S., not just high levels from nuclear disasters or bombings."Radiation, when it’s given unnecessarily, only causes risk," Dr. Howard Sandler, chair of radiation oncology at Cedars-Sinai in Los Angeles, told The Journal.SOURCE: The Wall Street Journal, July 16, 2025Copyright © 2025 HealthDay. All rights reserved.

Disposable Vapes Release Toxic Metals, Lab Study Says

By Dennis Thompson HealthDay ReporterFRIDAY, July 11, 2025 (HealthDay News) — People using cheap disposable vape devices are likely inhaling high...

By Dennis Thompson HealthDay ReporterFRIDAY, July 11, 2025 (HealthDay News) — People using cheap disposable vape devices are likely inhaling high levels of toxic metals with every puff, a recent study says.After a few hundred puffs, some disposable vapes start releasing levels of toxic metals higher than found in either last-generation refillable e-cigarettes or traditional tobacco smokes, researchers reported in the journal ACS Central Science.These metals can increase a person’s risk of cancer, lung disease and nerve damage, researchers said.“Our study highlights the hidden risk of these new and popular disposable electronic cigarettes — with hazardous levels of neurotoxic lead and carcinogenic nickel and antimony — which stresses the need for urgency in enforcement,” senior researcher Brett Poulin, an assistant professor of environmental toxicology at the University of California-Davis, said in a news release.Earlier studies found that the heating elements of refillable vapes could release metals like chromium and nickel into the vapor people breathe.For this study, researchers analyzed seven disposable devices from three well-known vape brands: ELF Bars, Flum Pebbles and Esco Bar.Before they were even used, some of the devices had surprisingly high levels of lead and antimony, researchers reported. The lead appears to have come from leaded copper alloys used in the devices, which leach into the e-liquid.The team then activated the disposable vapes, creating between 500 and 1,500 puffs for each device, to see whether their heating elements would release more metals.Analysis of the vapor revealed that:Levels of metals like chromium, nickel and antimony increased as the number of puffs increased, while concentrations of zinc, copper and lead were elevated at the start. Most of the tested disposables released higher amounts of metals than older refillable vapes. One disposable released more lead during a day’s use than one would get from nearly 20 packs of tobacco cigarettes. Nickel in three devices and antimony in two devices exceeded cancer risk limits. Four devices had nickel and lead emissions that surpassed health risk thresholds for diseases other than cancer. These results reflect only three of the nearly 100 disposable vape brands now available on store shelves, researchers noted.“Coupling the high element exposures and health risks associated with these devices and their prevalent use among the underage population, there is an urgent need for regulators to investigate this issue further and exercise regulatory enforcement accordingly,” researchers wrote.SOURCES: American Chemical Society, news release, June 20, 2025; ACS Central Science, June 25, 2025Copyright © 2025 HealthDay. All rights reserved.

Suggested Viewing

Join us to forge
a sustainable future

Our team is always growing.
Become a partner, volunteer, sponsor, or intern today.
Let us know how you would like to get involved!

CONTACT US

sign up for our mailing list to stay informed on the latest films and environmental headlines.

Subscribers receive a free day pass for streaming Cinema Verde.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.