Cookies help us run our site more efficiently.

By clicking “Accept”, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. View our Privacy Policy for more information or to customize your cookie preferences.

Everything you need to know to keep your teeth healthy

News Feed
Monday, March 17, 2025

Consumer Reports has no financial relationship with any advertisers on this site.With age comes a greater risk that things will go wrong with your teeth. Among adults, procedures such as filling cavities tend to peak in your early to mid-50s, according to the Health Policy Institute. By the time you reach your 60s, you’re almost certain to need treatment for tooth decay. Figuring out exactly what dental care you need and when can be challenging. Yet there’s one key step that’s simple and inexpensive: taking care of your teeth at home.Though certain dental problems may require extra attention, the basics of brushing twice daily and cleaning between your teeth by flossing haven’t changed. And while plenty of companies would like to sell you pricey gadgets and special products for your oral health, you don’t need to shell out big bucks to keep your mouth in great shape.How often for dental cleaning?Even with great home hygiene habits, you still need to see your dentist regularly for checkups and cleanings. Some people will need to visit more often than the standard twice a year, while others may be fine with less frequent visits. A 2020 review by Cochrane, an independent group of expert researchers, found that adults who visited the dentist every six months and those who visited on a schedule customized to their individual dental risk had comparable oral health.People who are being treated for periodontal disease or who have dental implants — which can fail more quickly than a natural tooth — may need to see their provider every three months or so, says Martha McComas, a clinical associate professor of dentistry at the University of Michigan School of Dentistry in Ann Arbor.Your dentist can help you figure out the right cadence for checkups, as well as your optimal at-home dental care strategy. “We can customize it based on what we see in your mouth,” says Karin Arsenault, program director of geriatric dentistry at the Tufts University School of Dental Medicine in Boston.Between visits, here’s what you need to know about the vital tools for keeping your teeth and your whole mouth as healthy as they can be.Your toothpaste mattersFluoride is important. Fluoride is crucial because of the power it has to help fight cavities and tooth decay — something proved by decades of research. While some ingredients, notably a chemical called hydroxyapatite, have shown promise as viable alternatives, fluoride is still your best choice right now, according to the American Dental Association.Cavities occur when the bacteria in our mouths consume the traces of food left on our teeth, particularly anything sugary. As the bacteria gobble up these sugars, they release acid, which can remove minerals from our teeth’s enamel, eventually creating cavities. Fluoride can help replace some of these lost minerals, strengthening the surface of our teeth and repairing some damage.When you’re shopping for toothpaste, look for one with the ADA Seal of Acceptance. To earn that seal, manufacturers need to not only include fluoride in their toothpaste but also meet other safety and efficacy standards, including one meant to ensure toothpastes aren’t too abrasive. (Very abrasive toothpastes can damage enamel.)Watch out for this ingredient: If you’re prone to canker sores inside your mouth, you may want to look for a toothpaste that doesn’t contain sodium lauryl sulfate (SLS). A 2019 research review found that using an SLS-free toothpaste might help reduce canker sores in people who get a lot of them (about 25 percent of adults).Skip charcoal toothpaste. Activated charcoal is often touted as a superior ingredient for a variety of products, including toothpaste. But it can be highly abrasive, which research has shown can damage your enamel and cause increased sensitivity.How much toothpaste to use: Generally, adults need only a pea-size amount of toothpaste — that will create enough foam to cover all the surfaces in your mouth, Arsenault says.Also, “one of the big myths about toothbrushing is that you should rinse your mouth out after you brush,” says McComas. Studies show that the fluoride in your toothpaste provides the biggest benefit if you don’t do this, instead allowing the fluoride to work its magic on your enamel for more time.What about prescription pastes? You may want to ask your dentist whether a prescription toothpaste, which generally contains a higher dose of fluoride, might be right for you. Severe dry mouth, which can be more common as you age (particularly if you’re taking certain medications for various chronic conditions, including for high blood pressure and depression), can raise your risk of cavities. So can periodontal disease, especially if the surfaces of the roots of your teeth, which lack protective enamel, are exposed.How to brush wellThe right bristles: Use a toothbrush with soft or extra-soft bristles. There are so many toothbrush options, but in the midst of considering the shape of the brush head, the brand name and other fancy features, don’t lose sight of bristle stiffness. Seek out a toothbrush with “soft” or “extra soft” on the packaging. Stiffer bristles are more likely to damage your gums or your teeth’s enamel, according to the American Dental Association.The advantages of an electric toothbrush: You can keep your mouth perfectly healthy with a manual toothbrush, but a 2014 Cochrane review found that three months of using an electric toothbrush resulted in 21 percent less plaque and 11 percent less gum inflammation (also called gingivitis).There are not significant performance differences between oscillating (or rotating) electric toothbrushes, which typically have round heads, and sonic toothbrushes, which usually have rectangular heads. So get the kind you like and will use.How much to brush: Do it twice a day for at least two minutes. Some research suggests that people may brush for a lot less time than this on average, possibly around a minute or less. But common sense and a 2009 Journal of Dental Hygiene study suggest that brushing longer will remove more plaque — though the added benefit of extra time beyond two minutes is probably marginal, and brushing too hard can exacerbate problems, including receding gums, which can expose the roots of your teeth to a greater risk of cavities and tooth decay.How to flossWhy flossing matters: Use any standard string floss (waxed or unwaxed), floss pick or interdental cleaning brush. The scientific evidence for flossing is not as strong as it is for brushing: A 2019 Cochrane review found that flossing in addition to brushing may reduce plaque and gingivitis more than brushing alone, but the authors cautioned that the evidence supporting this conclusion was weak. Still, dentists say the biological justification for flossing is sound: Without it, the bacteria that cause decay can build up between your teeth even if you’re brushing regularly.Do water flossers work? While not quite as effective as string floss, water flossers can be a great option if you have a hard time using string floss, have mouth hardware like braces or a permanent retainer, or have other kinds of dental work like implants, bridges, or crowns. Dentist Sally Cram, a spokeswoman for the American Dental Association, says the evidence on the benefits of a water flosser is encouraging, but it’s not enough for her to recommend it as a replacement for flossing just yet. Still, if you know you won’t use string floss every day, a water flosser is better than nothing.Avoid floss with PFAS. Skip floss that’s coated with these environmental contaminants, which are associated with a variety of health problems. You can look for flosses that use non-PFAS coatings such as beeswax or plant waxes like carnauba or candelilla.CR partnered with Made Safe, an independent organization that certifies products as safer and more sustainable, to find flosses made without PFAS. Read our special report, “How to Choose Dental Floss Without PFAS and Other Harmful Chemicals,” for the details, including three good floss options made from silk instead of plastic.How often should you floss? Do it once a day. Whether you floss or brush first doesn’t matter, as long as you do both.What if you have implants or gum disease? If you have an implant, you may want to opt for an interdental brush instead of regular string floss, particularly if your implant doesn’t touch the teeth next to it on either side.These are tiny round brushes designed specifically to clean in between teeth, and they work well with teeth that have gaps in between them. They come in different sizes, so Jennifer Harmon, a registered dental hygienist and clinical associate professor at the University of North Carolina Adams School of Dentistry in Chapel Hill, recommends working with your dentist to figure out which size you need for your teeth.If you’re dealing with bleeding gums, Arsenault says, you can consider using prescription chlorhexidine mouthwash after you floss. Just be sure to follow your dentist’s instructions, because chlorhexidine can also cause some tooth staining and changes in taste.Do you need these dental tools?Tongue scrapers: The experts we spoke with say this is a great tool. The bacteria that cause tooth decay don’t just live on your teeth; they can collect on your tongue, too. That means you should clean your tongue daily. You can do this with your toothbrush bristles or the ridged back of some brushes, but a tongue scraper can be a little more effective, Cram says.Plus, scraping your tongue is a great habit if you struggle with halitosis (bad breath), says Roxanne Dsouza-Norwood, a registered dental hygienist and clinical assistant professor of dental hygiene at the University of North Carolina at Chapel Hill. But be gentle; otherwise you could accidentally lacerate your tongue. And you may need to experiment with different types of tongue scrapers to find one that doesn’t activate your gag reflex.Whitening strips: Over-the-counter whitening strips can help your teeth look whiter, but it can sometimes be difficult to spot the change, McComas says. You can try using them only on the upper teeth first so that the difference is more visible. (Then apply them to the lower teeth.) Keep in mind that the older you get, the more you can see the yellowish dentin underneath your enamel, which — along with crowns and implants — is not affected by strips. So you might end up with uneven colors.Strips can also cause sensitivity, particularly if you already have sensitive areas from gum recession, Cram says. So leave them on only as long as instructed on the package.Mouthwash: Because swishing it around can coat parts of your teeth’s surface that are harder to reach with other tools, mouthwash can be a nice adjunct to your dental care routine, particularly if you choose one that has fluoride. Prescription washes that contain chlorhexidine can also be helpful for people with bleeding gums or other severe gum problems.Consumer Reports is an independent, nonprofit organization that works side by side with consumers to create a fairer, safer and healthier world. CR does not endorse products or services and does not accept advertising. Read more at ConsumerReports.org.

From brushing to whitening to the timing for dental cleanings, and everything in between.

Consumer Reports has no financial relationship with any advertisers on this site.

With age comes a greater risk that things will go wrong with your teeth. Among adults, procedures such as filling cavities tend to peak in your early to mid-50s, according to the Health Policy Institute. By the time you reach your 60s, you’re almost certain to need treatment for tooth decay. Figuring out exactly what dental care you need and when can be challenging. Yet there’s one key step that’s simple and inexpensive: taking care of your teeth at home.

Though certain dental problems may require extra attention, the basics of brushing twice daily and cleaning between your teeth by flossing haven’t changed. And while plenty of companies would like to sell you pricey gadgets and special products for your oral health, you don’t need to shell out big bucks to keep your mouth in great shape.

How often for dental cleaning?

Even with great home hygiene habits, you still need to see your dentist regularly for checkups and cleanings. Some people will need to visit more often than the standard twice a year, while others may be fine with less frequent visits. A 2020 review by Cochrane, an independent group of expert researchers, found that adults who visited the dentist every six months and those who visited on a schedule customized to their individual dental risk had comparable oral health.

People who are being treated for periodontal disease or who have dental implants — which can fail more quickly than a natural tooth — may need to see their provider every three months or so, says Martha McComas, a clinical associate professor of dentistry at the University of Michigan School of Dentistry in Ann Arbor.

Your dentist can help you figure out the right cadence for checkups, as well as your optimal at-home dental care strategy. “We can customize it based on what we see in your mouth,” says Karin Arsenault, program director of geriatric dentistry at the Tufts University School of Dental Medicine in Boston.

Between visits, here’s what you need to know about the vital tools for keeping your teeth and your whole mouth as healthy as they can be.

Your toothpaste matters

Fluoride is important. Fluoride is crucial because of the power it has to help fight cavities and tooth decay — something proved by decades of research. While some ingredients, notably a chemical called hydroxyapatite, have shown promise as viable alternatives, fluoride is still your best choice right now, according to the American Dental Association.

Cavities occur when the bacteria in our mouths consume the traces of food left on our teeth, particularly anything sugary. As the bacteria gobble up these sugars, they release acid, which can remove minerals from our teeth’s enamel, eventually creating cavities. Fluoride can help replace some of these lost minerals, strengthening the surface of our teeth and repairing some damage.

When you’re shopping for toothpaste, look for one with the ADA Seal of Acceptance. To earn that seal, manufacturers need to not only include fluoride in their toothpaste but also meet other safety and efficacy standards, including one meant to ensure toothpastes aren’t too abrasive. (Very abrasive toothpastes can damage enamel.)

Watch out for this ingredient: If you’re prone to canker sores inside your mouth, you may want to look for a toothpaste that doesn’t contain sodium lauryl sulfate (SLS). A 2019 research review found that using an SLS-free toothpaste might help reduce canker sores in people who get a lot of them (about 25 percent of adults).

Skip charcoal toothpaste. Activated charcoal is often touted as a superior ingredient for a variety of products, including toothpaste. But it can be highly abrasive, which research has shown can damage your enamel and cause increased sensitivity.

How much toothpaste to use: Generally, adults need only a pea-size amount of toothpaste — that will create enough foam to cover all the surfaces in your mouth, Arsenault says.

Also, “one of the big myths about toothbrushing is that you should rinse your mouth out after you brush,” says McComas. Studies show that the fluoride in your toothpaste provides the biggest benefit if you don’t do this, instead allowing the fluoride to work its magic on your enamel for more time.

What about prescription pastes? You may want to ask your dentist whether a prescription toothpaste, which generally contains a higher dose of fluoride, might be right for you. Severe dry mouth, which can be more common as you age (particularly if you’re taking certain medications for various chronic conditions, including for high blood pressure and depression), can raise your risk of cavities. So can periodontal disease, especially if the surfaces of the roots of your teeth, which lack protective enamel, are exposed.

How to brush well

The right bristles: Use a toothbrush with soft or extra-soft bristles. There are so many toothbrush options, but in the midst of considering the shape of the brush head, the brand name and other fancy features, don’t lose sight of bristle stiffness. Seek out a toothbrush with “soft” or “extra soft” on the packaging. Stiffer bristles are more likely to damage your gums or your teeth’s enamel, according to the American Dental Association.

The advantages of an electric toothbrush: You can keep your mouth perfectly healthy with a manual toothbrush, but a 2014 Cochrane review found that three months of using an electric toothbrush resulted in 21 percent less plaque and 11 percent less gum inflammation (also called gingivitis).

There are not significant performance differences between oscillating (or rotating) electric toothbrushes, which typically have round heads, and sonic toothbrushes, which usually have rectangular heads. So get the kind you like and will use.

How much to brush: Do it twice a day for at least two minutes. Some research suggests that people may brush for a lot less time than this on average, possibly around a minute or less. But common sense and a 2009 Journal of Dental Hygiene study suggest that brushing longer will remove more plaque — though the added benefit of extra time beyond two minutes is probably marginal, and brushing too hard can exacerbate problems, including receding gums, which can expose the roots of your teeth to a greater risk of cavities and tooth decay.

How to floss

Why flossing matters: Use any standard string floss (waxed or unwaxed), floss pick or interdental cleaning brush. The scientific evidence for flossing is not as strong as it is for brushing: A 2019 Cochrane review found that flossing in addition to brushing may reduce plaque and gingivitis more than brushing alone, but the authors cautioned that the evidence supporting this conclusion was weak. Still, dentists say the biological justification for flossing is sound: Without it, the bacteria that cause decay can build up between your teeth even if you’re brushing regularly.

Do water flossers work? While not quite as effective as string floss, water flossers can be a great option if you have a hard time using string floss, have mouth hardware like braces or a permanent retainer, or have other kinds of dental work like implants, bridges, or crowns. Dentist Sally Cram, a spokeswoman for the American Dental Association, says the evidence on the benefits of a water flosser is encouraging, but it’s not enough for her to recommend it as a replacement for flossing just yet. Still, if you know you won’t use string floss every day, a water flosser is better than nothing.

Avoid floss with PFAS. Skip floss that’s coated with these environmental contaminants, which are associated with a variety of health problems. You can look for flosses that use non-PFAS coatings such as beeswax or plant waxes like carnauba or candelilla.

CR partnered with Made Safe, an independent organization that certifies products as safer and more sustainable, to find flosses made without PFAS. Read our special report, “How to Choose Dental Floss Without PFAS and Other Harmful Chemicals,” for the details, including three good floss options made from silk instead of plastic.

How often should you floss? Do it once a day. Whether you floss or brush first doesn’t matter, as long as you do both.

What if you have implants or gum disease? If you have an implant, you may want to opt for an interdental brush instead of regular string floss, particularly if your implant doesn’t touch the teeth next to it on either side.

These are tiny round brushes designed specifically to clean in between teeth, and they work well with teeth that have gaps in between them. They come in different sizes, so Jennifer Harmon, a registered dental hygienist and clinical associate professor at the University of North Carolina Adams School of Dentistry in Chapel Hill, recommends working with your dentist to figure out which size you need for your teeth.

If you’re dealing with bleeding gums, Arsenault says, you can consider using prescription chlorhexidine mouthwash after you floss. Just be sure to follow your dentist’s instructions, because chlorhexidine can also cause some tooth staining and changes in taste.

Do you need these dental tools?

Tongue scrapers: The experts we spoke with say this is a great tool. The bacteria that cause tooth decay don’t just live on your teeth; they can collect on your tongue, too. That means you should clean your tongue daily. You can do this with your toothbrush bristles or the ridged back of some brushes, but a tongue scraper can be a little more effective, Cram says.

Plus, scraping your tongue is a great habit if you struggle with halitosis (bad breath), says Roxanne Dsouza-Norwood, a registered dental hygienist and clinical assistant professor of dental hygiene at the University of North Carolina at Chapel Hill. But be gentle; otherwise you could accidentally lacerate your tongue. And you may need to experiment with different types of tongue scrapers to find one that doesn’t activate your gag reflex.

Whitening strips: Over-the-counter whitening strips can help your teeth look whiter, but it can sometimes be difficult to spot the change, McComas says. You can try using them only on the upper teeth first so that the difference is more visible. (Then apply them to the lower teeth.) Keep in mind that the older you get, the more you can see the yellowish dentin underneath your enamel, which — along with crowns and implants — is not affected by strips. So you might end up with uneven colors.

Strips can also cause sensitivity, particularly if you already have sensitive areas from gum recession, Cram says. So leave them on only as long as instructed on the package.

Mouthwash: Because swishing it around can coat parts of your teeth’s surface that are harder to reach with other tools, mouthwash can be a nice adjunct to your dental care routine, particularly if you choose one that has fluoride. Prescription washes that contain chlorhexidine can also be helpful for people with bleeding gums or other severe gum problems.

Consumer Reports is an independent, nonprofit organization that works side by side with consumers to create a fairer, safer and healthier world. CR does not endorse products or services and does not accept advertising. Read more at ConsumerReports.org.

Read the full story here.
Photos courtesy of

Gas stove makers quietly delete air pollution warnings as they fight mandatory health labels

Manufacturers sued to stop a Colorado law requiring air quality warnings, arguing gas stoves are safe. Some of their websites once said the opposite.

The home appliance industry would like you to believe that gas-burning stoves are not a risk to your health — and several companies that make the devices are scrambling to erase their prior acknowledgements that they are.  That claim is at the heart of a lawsuit the Association of Home Appliance Manufacturers has filed against the state of Colorado to stop it from requiring natural gas stoves, which burn methane, to carry health labels not unlike those on every pack of cigarettes. “Understand the air quality implications of having an indoor gas stove,” the warning would read. The law was to take effect August 5 but is now on hold, and state officials did not respond to a request for comment. In its federal lawsuit, the Association — whose board includes representatives of LG Electronics, BSH Home Appliance Corp. (which makes Bosch appliances), Whirlpool, and Samsung Electronics — asserts that the labeling requirement is “unconstitutional compelled speech” and illegal under the First Amendment. It calls the legislation a climate law disguised as a health law and, most strikingly, it claims there is “no association between gas stoves and adverse health outcomes.”  Yet LG, BSH, Whirlpool, and Samsung have published information on their websites directly contradicting that claim and lauded the health benefits of electric and induction stoves.  “Traditional gas appliances can emit harmful pollutants, which can compromise indoor air quality and pose health risks,” reads a blog post, titled “Life’s Good When It’s Electrified,” that LG published in May of 2024. “By switching to electric appliances, these risks are substantially reduced, ensuring a cleaner and safer home environment.”  Another LG page noted that “induction surfaces remain cool to the touch and unlike gas, is better for kitchen air quality” as recently as May 25, according to an archived version of the site maintained by Wayback Machine. It was later revised to eliminate mention of gas, reading “Surfaces remain cool to the touch — no open flames or hot coils. No fumes, either, so it’s [sic] air quality-friendly.” BSH’s page on Bosch induction cooktops notes that the devices are “safer to use because unlike other types of cooktops, they do not release indoor air pollutants during cooking.” Whirlpool wrote that induction cooktops might help “reduce indoor air pollutants.”  And until last week, a page on Samsung’s U.S. website said “induction cooktops can … help remove concerns over indoor air pollution, creating a sustainable and healthier home environment. The page’s source code did not appear to have been updated since 2022. Samsung did not respond to multiple requests for comment, but the page was taken down shortly after Grist reached out to the company.  Itai Vardi, a researcher with the Energy and Policy Institute, was the first to notice the discrepancies between what the Association said in its lawsuit and what some of its manufacturers have said in the past. “The statements coming from them directly contradict the very strong language in this lawsuit,” Vardi said. “And that, I think, deserves some scrutiny.” Scientific evidence that gas stoves pollute by releasing dangerous concentrations of nitrogen dioxide, benzene, and methane has accumulated since 1970. Justin Paget / Getty Images In its lawsuit, the Association argues that “the potential health risks of cooking with gas are no different than cooking with electricity” and acknowledging the ways gas-burning appliances can harm respiratory health promotes “non-consensus, scientifically controversial, and factually misleading” messages. It adds that “there is scant scientific support” for disclosing health risks associated with gas appliances.  Asked for comment, the organization referred to a statement it issued August 6 saying “no study has found that gas stoves cause respiratory health issues.”  When reached for comment, a BSH representative stated that the company is as of now “in complete alignment” with the Association’s position. An LG representative noted that the most pollution-acknowledging statements on their website were in fact made by the company’s UK branch, but did not respond to a follow-up question about whether the UK and US divisions disagree on the risks of LG products. “This is a troubling attempt by these companies’ to quickly erase their own public acknowledgement of the dangers of gas stoves,” said Vardi. “But you can scrub your website, not the fact of gas stove pollution.”  Scientific evidence that gas stoves pollute by releasing dangerous concentrations of nitrogen dioxide, benzene, and methane has piled up for the past half-century. In 1970, scientist Carl Shy showed that families exposed to high levels of nitrogen dioxide indoors are at greater risk of asthma and other respiratory illnesses than those who are not. Nine years later, scientist Bernard Goldstein identified the fuel as the likely source of all that nitrogen. A bevy of studies and papers in the decades since came to similar conclusions. One 2022 study estimated that 12 percent of American children with asthma develop that respiratory condition solely due to living in homes with gas stoves.  Appliance manufacturers and the natural gas industry are no stranger to promoting their products regardless of known health risks. “There’s been a campaign by industry to keep the science under wraps or to confuse it, deny it,” said Abe Scarr of the consumer-protection nonprofit Public Interest Working Group.  The lobbyists at the American Gas Association have worked hard to popularize gas stoves: At one point, the organization even provided the stoves Julia Child used in her popular cooking show. The campaign went beyond product placement: When information on the health risks of gas stoves began to emerge in the mid-1970s, industry lobbyists launched “Operation Attack,” a million-dollar marketing campaign to bring the stoves into even more kitchens. This worked: today, about 40% of Americans cook with gas. They also funded their own research, which cast doubt on independent findings on the health risks of gas stoves.  Environmental health sciences professor Misbath Daouda of the University of California, Berkeley, was recently part of a pilot study replacing gas stoves in low-income New York City apartments with induction stoves. Nitrogen dioxide concentrations in those apartments, she said, dropped by over 50 percent within months – and the families who lived there liked their new cooktops better than the old ones, she said.  The association between gas stoves and adverse health outcomes, Daouda said, “is clear.”  “I’m not sure who they are referring to when they say the majority of studies” don’t support that conclusion, she said. This story was originally published by Grist with the headline Gas stove makers quietly delete air pollution warnings as they fight mandatory health labels on Sep 17, 2025.

New Biomarker Could Detect Alzheimer’s Years Before Symptoms Appear

TSPO levels rise early in Alzheimer’s and persist throughout disease. Targeting this biomarker could open new treatment options. TSPO, a major marker of brain inflammation, may offer a way to detect Alzheimer’s disease long before memory problems and other symptoms develop. Findings published in Acta Neuropathologica suggest it could transform both diagnosis and treatment strategies. [...]

A new study suggests that TSPO, a key biomarker of brain inflammation, may reveal the earliest stages of Alzheimer’s disease long before symptoms appear. Credit: StockTSPO levels rise early in Alzheimer’s and persist throughout disease. Targeting this biomarker could open new treatment options. TSPO, a major marker of brain inflammation, may offer a way to detect Alzheimer’s disease long before memory problems and other symptoms develop. Findings published in Acta Neuropathologica suggest it could transform both diagnosis and treatment strategies. “This is the first study to really examine how early this biomarker increases and where it begins rising in the brain,” said Tomás R. Guilarte, lead researcher and dean of FIU’s Robert Stempel College of Public Health & Social Work. “If we can use this information to help delay Alzheimer’s progression by even five years, it can drastically improve patients’ lives and reduce disease prevalence.” Longstanding research on TSPO Guilarte, a recognized authority on TSPO (translocator protein 18 kDa), has investigated the protein for more than 30 years. His research helped establish it as a dependable imaging marker for identifying neuroinflammation across multiple neurological, neurodegenerative, and psychiatric conditions. Researchers Daniel Martínez Pérez (L) and Dr. Tomás R. Guilarte (R) in the Brain, Behavior and the Environment Laboratory at Florida International University. Guilarte and Martínez Pérez published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International UniversityFor the current study, Guilarte and colleagues applied advanced imaging techniques to track TSPO activity in genetically engineered mouse models of familial Alzheimer’s. They then validated these results using donated brain tissue from members of the world’s largest community with early-onset familial Alzheimer’s, based in Antioquia, Colombia. These families carry the “paisa” mutation, first identified by the late Dr. Francisco Lopera, a co-author of the study who spent his career searching for ways to prevent Alzheimer’s. Individuals with this genetic variant often develop symptoms in their 30s or 40s and typically die in their 50s. L: The original cell image. R: The same cell image zoomed in and rendered in the special imaging software. Microglia (blue) signaling TSPO (red) are clustered around plaques (cyan). Researchers at Florida International University published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in.  Credit: Chris Necuze, Florida International UniversityEarly changes in the hippocampus In the mouse model, researchers detected elevated TSPO levels in the subiculum – a critical part of the hippocampus – as early as six weeks of age, roughly equivalent to age 18–20 in humans. Microglia, the brain’s main immune cells, specifically those clustered around amyloid plaques, had the highest levels of TSPO. Notably, female mice had higher TSPO levels, mirroring real-world statistics: two-thirds of Alzheimer’s patients are women. Daniel Martínez Pérez holds tissue sample. Martínez Pérez, a researcher in Florida International University’s Robert Stempel College of Public Health & Social Work, is the first author of a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International UniversityThe brain tissue samples from the Colombian patients with the paisa mutation showed the same pattern. Even in late-stage Alzheimer’s, TSPO remained high in microglia near plaques. These results raise new questions about TSPO’s function – whether it contributes to damage or protects the brain – and whether blocking or enhancing it could halt disease progression. Next steps in research The team is now working with a specially developed Alzheimer’s mouse model lacking TSPO to explore these questions further. They’re also expanding the study to include sporadic, late-onset Alzheimer’s cases, the form that accounts for over 90% of all diagnoses. Researchers Dr. Tomás R. Guilarte (L) and Daniel Martínez Pérez (R) in the Brain, Behavior and the Environment Laboratory at Florida International University. Guilarte and Martínez Pérez published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International University“The more we understand these processes,” said Daniel Martínez Pérez, first author and Ph.D. candidate in Guilarte’s lab, “the closer we get to tailoring treatments that can truly help – before it’s too late.” Reference: “Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer’s disease” by Daniel A. Martinez-Perez, Jennifer L. McGlothan, Alexander N. Rodichkin, Karam Abilmouna, Zoran Bursac, Francisco Lopera, Carlos Andres Villegas-Lanau and Tomás R. Guilarte, 17 July 2025, Acta Neuropathologica.DOI: 10.1007/s00401-025-02912-4 This work was supported by grants ES007062-24 to T.R.G. from the National Institute of Environmental Health Sciences (NIEHS), ES007062-23S1 to T.R.G. from the National Institute on Aging, and T32-ES033955 to A.N.R. from the NIEHS. Never miss a breakthrough: Join the SciTechDaily newsletter.

Living Near Polluted Missouri Creek as a Child Tied to Later Cancer Risk

By I. Edwards HealthDay ReporterTHURSDAY, July 17, 2025 (HealthDay News) — Folks who grew up near a polluted Missouri creek during the 1940s...

THURSDAY, July 17, 2025 (HealthDay News) — Folks who grew up near a polluted Missouri creek during the 1940s through 1960s may have higher odds for cancer now, new research shows.The study focused on Coldwater Creek in St. Louis County. The area was contaminated with radioactive waste from the U.S. government’s atomic bomb program during World War II.Back then, uranium was processed in St. Louis and nuclear waste was stored near the city’s airport. That waste leaked into Coldwater Creek, which runs through several residential neighborhoods.Researchers found that people who lived within one kilometer (0.62 miles) of the creek as kids had an 85% higher risk of developing certain cancers later in life compared to those who lived more than 20 kilometers (12.4 miles) away.Those cancers include leukemia, thyroid cancer and breast cancer, which are known to be linked to radiation exposure.“The closer the childhood residence got to Coldwater Creek, the risk of cancer went up, and pretty dramatically," lead researcher Marc Weisskopf, a professor of epidemiology at Harvard T.H. Chan School of Public Health, told The Wall Street Journal.For the study, Weisskopf’s team surveyed more than 4,200 adults who lived in the St. Louis area as children between 1958 and 1970.These people had donated their baby teeth years ago for radiation research. The new survey asked about cancer and other health issues.About 1 in 4 participants said they had been diagnosed with cancer. Risk dropped the farther someone lived from the creek as a child.Outside experts who reviewed the findings described them as concerning.“It emphasizes the importance of appreciating that radioactive waste is carcinogenic, particularly to children, and that we have to ensure that we have to clean up any remaining waste that’s out there,” Dr. Rebecca Smith-Bindman, a radiation risk expert at the University of California, San Francisco, told The Journal.In 2024, the U.S. Army Corps of Engineers began placing warning signs along parts of the creek that still have radioactive waste, The Journal reported.The U.S. Agency for Toxic Substances and Disease Registry reported in 2019 that contamination have raised the risk of leukemia and lung and bone cancer. Later exposures, starting in the 2000s, were linked to a slight increase in lung cancer for those who lived nearby.But the agency said it’s hard to link any one person’s cancer directly to radiation. Genetics, lifestyle and other factors could also play a role.In this study, radiation exposure wasn’t directly measured. Cancer cases were also self-reported, not confirmed by medical records. Weisskopf plans to measure radiation levels using the stored baby teeth in future research.Radiation exposure has long been tied to cancer, but this study is among the first to look at lower, long-term environmental exposure in the U.S., not just high levels from nuclear disasters or bombings."Radiation, when it’s given unnecessarily, only causes risk," Dr. Howard Sandler, chair of radiation oncology at Cedars-Sinai in Los Angeles, told The Journal.SOURCE: The Wall Street Journal, July 16, 2025Copyright © 2025 HealthDay. All rights reserved.

Disposable Vapes Release Toxic Metals, Lab Study Says

By Dennis Thompson HealthDay ReporterFRIDAY, July 11, 2025 (HealthDay News) — People using cheap disposable vape devices are likely inhaling high...

By Dennis Thompson HealthDay ReporterFRIDAY, July 11, 2025 (HealthDay News) — People using cheap disposable vape devices are likely inhaling high levels of toxic metals with every puff, a recent study says.After a few hundred puffs, some disposable vapes start releasing levels of toxic metals higher than found in either last-generation refillable e-cigarettes or traditional tobacco smokes, researchers reported in the journal ACS Central Science.These metals can increase a person’s risk of cancer, lung disease and nerve damage, researchers said.“Our study highlights the hidden risk of these new and popular disposable electronic cigarettes — with hazardous levels of neurotoxic lead and carcinogenic nickel and antimony — which stresses the need for urgency in enforcement,” senior researcher Brett Poulin, an assistant professor of environmental toxicology at the University of California-Davis, said in a news release.Earlier studies found that the heating elements of refillable vapes could release metals like chromium and nickel into the vapor people breathe.For this study, researchers analyzed seven disposable devices from three well-known vape brands: ELF Bars, Flum Pebbles and Esco Bar.Before they were even used, some of the devices had surprisingly high levels of lead and antimony, researchers reported. The lead appears to have come from leaded copper alloys used in the devices, which leach into the e-liquid.The team then activated the disposable vapes, creating between 500 and 1,500 puffs for each device, to see whether their heating elements would release more metals.Analysis of the vapor revealed that:Levels of metals like chromium, nickel and antimony increased as the number of puffs increased, while concentrations of zinc, copper and lead were elevated at the start. Most of the tested disposables released higher amounts of metals than older refillable vapes. One disposable released more lead during a day’s use than one would get from nearly 20 packs of tobacco cigarettes. Nickel in three devices and antimony in two devices exceeded cancer risk limits. Four devices had nickel and lead emissions that surpassed health risk thresholds for diseases other than cancer. These results reflect only three of the nearly 100 disposable vape brands now available on store shelves, researchers noted.“Coupling the high element exposures and health risks associated with these devices and their prevalent use among the underage population, there is an urgent need for regulators to investigate this issue further and exercise regulatory enforcement accordingly,” researchers wrote.SOURCES: American Chemical Society, news release, June 20, 2025; ACS Central Science, June 25, 2025Copyright © 2025 HealthDay. All rights reserved.

Suggested Viewing

Join us to forge
a sustainable future

Our team is always growing.
Become a partner, volunteer, sponsor, or intern today.
Let us know how you would like to get involved!

CONTACT US

sign up for our mailing list to stay informed on the latest films and environmental headlines.

Subscribers receive a free day pass for streaming Cinema Verde.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.