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Could a CA bill on tortillas improve maternal health?

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Monday, April 15, 2024

A premature baby in incubator. Photo via iStock California is struggling to provide maternal health for its residents. But as one proposal aims to prevent birth defects, another has received hateful pushback that’s been condemned by both political parties. As CalMatters health reporter Ana B. Ibarra writes, Assemblymember Joaquin Arambula has introduced a bill that would require corn masa flour makers to add 0.7 milligrams of folic acid per pound of flour. Though federal law requires other grain products, such as cereals, breads and pasta, be fortified with folic acid, corn masa flour is not included. The corn flour is a key ingredient used in many classic Latino foods. Arambula, a Fresno Democrat and physician, to CalMatters: “Food is the best way that we can get folic acid into our communities before they’re pregnant. Oftentimes the prenatal vitamins that we give to pregnant people are too late.”  Research has shown that folic acid, which can be found in prenatal and women’s multi-vitamins, promotes healthy cell growth, and can prevent birth defects when taken before and during the early weeks of pregnancy. Since 1998, when the U.S. Food and Drug Administration handed down the requirement, the proportion of babies born with neural tube defects dropped by 35%. But between 2017 and 2019, only about 28% of Latinas reported taking folic acid the month before becoming pregnant, compared to 46% of white women. Women on Medi-Cal, the state’s health insurance program for low-income families, are also less likely to take folic acid before pregnancy compared to women on private insurance.  To learn more about the proposal, read Ana’s story. Another bill related to maternal health, Assembly Bill 2319, was the subject of a racist letter sent to members of the Health Committee, according to lawmakers. The measure would require healthcare providers to undergo training for implicit bias, and for the training to include “recognition of intersecting identities.”  The bill’s co-author, Assemblymember Lori Wilson, said the letter was “vile and hateful.” Assembly Republicans also said the letter had no place in legislative debate: “While we may not always agree on policy, we are united to strongly condemn racism and the evil ideology behind this letter.” Wilson, a Suisun City Democrat who is chairperson of the Legislative Black Caucus, vowed to carry on with the measure. The proposals by Arumbula and Wilson follow state data showing that in 2020 California saw a ten-year high of pregnancy-related deaths. Black expectant mothers are particularly vulnerable: They are three times more likely to die of pregnancy-related complications than others. It’s a point raised by former state Senate leader Toni Atkins in a social media post last week. Meanwhile, maternity wards across the state are closing, creating “maternity care deserts,” and California midwives treating Medi-Cal patients struggle to keep their businesses afloat. A February report from the state auditor also found that state health departments failed to track the effectiveness of a perinatal care program for Medi-Cal patients. Digital Democracy: CalMatters has launched Digital Democracy, a project using the latest technologies to help Californians understand their state government and create more accountability for politicians. The website introduces each of the state’s 120 legislators and explains this year’s policy agenda. In our unprecedented database, you can instantly find any word uttered in a public hearing, every vote cast, every bill introduced and every dollar donated. For more details, see our about and methodology pages and read more from our engagement team. Other Stories You Should Know Builders can challenge impact fees New housing construction in a neighbourhood in Elk Grove on July 8, 2022. Photo by Rahul Lal, CalMatters From CalMatters housing reporter Ben Christopher:It’s about to get more difficult for local governments to slap construction projects with certain fees — and a bit easier for developers to sue governments when they do.  That’s thanks to a unanimous ruling the U.S. Supreme Court handed down Friday. As many court watchers expected, the justices sided with George Sheetz, a septuagenarian retiree who sued El Dorado County over a $23,420 building fee. Sheetz’s lawyers argued that the county should have had to prove that this five-digit fee matched the cost that his manufactured home actually would inflict on local roads and highways. That requirement was established in a four-decade-old court ruling also out of California. El Dorado County, with the backing of both the Gov. Gavin Newsom and President Joe Biden administrations, countered that such a high bar is only required of one-off fees levied by regulators, not fees scheduled for all developments and established by elected bodies, like the county board of supervisors. In its 9-0 ruling, the Supreme Court said that “there is no basis for affording property rights less protection in the hands of legislators than administrators.” A few possible consequences of the ruling: Cities and counties now have to show that impact fees are connected to and “roughly proportionate” to the fiscal impact of a given development. That could have the unintended consequence of slowing down permitting.  Developers may now have a powerful new legal tool to challenge fees that they think are too high. And they are high here. As of 2015, the average impact fee on a single family home in California was more than four times the national average. But it’s too soon to say exactly how all of this will shake out. That’s because the court stopped short of saying exactly how far governments have to go to justify their fees — or whether El Dorado County already cleared that hurdle in this case. Those questions were left to lower courts. State cracks down on water Armona’s new $9 million well and treatment facility to remove arsenic in its water supply. Photo by Larry Valenzuela, CalMatters/CatchLight Local The State Water Resources Control Board is poised to penalize Kings County groundwater agencies for failing to manage overpumping in the region’s water supply — a move that would set a new precedent. As CalMatters water reporter Rachel Becker explains, the board on Tuesday is expected to decide whether to put county agencies on probation for unsuccessfully restricting farmers’ overdrafting of the water supply from the Tulare Lake underground basin. If the board decides to crack down, it will be the first time the state imposes penalties under a landmark 2014 law that requires agencies to achieve groundwater sustainability by 2040.The board’s decision could also signal how the state will approach five other overpumped San Joaquin Valley basins that may face probation as well. Overpumping in Kings County has caused household and community water wells to dry up and land to sink, which endangers canals, aqueducts and flood-controlling levees. And because wells must reach deeper into the ground to extract water, contaminants such as arsenic are released and cause water contamination levels to rise. Putting Kings County agencies on probation could mean imposing state fees totaling as much as $10 million a year, according to a CalMatters analysis. It could also lead to state regulators eventually managing the region’s groundwater. This has small farmers in the region concerned that they’ll be forced out of business due to the state’s steep fees. The basin provides drinking and irrigation water for 146,000 residents and supports a multibillion-dollar agricultural industry. For more on this issue, read Rachel’s story. California’s water crisis, explained: CalMatters has a detailed look at how California might increase its water supply, and a dashboard tracking the state’s water situation. CalMatters Commentary Ideas festival: CalMatters is hosting its first one, in Sacramento on June 5-6. It will include a discussion on broadband access and a session with Zócalo Public Square on California’s next big idea. Featured speakers include Julián Castro, CEO of the Latino Community Foundation, and Barbara McQuade, a former U.S. attorney and MSNBC legal analyst. Find out more from our engagement team and buy tickets here. Other things worth your time: Some stories may require a subscription to read. CA granted federal disaster relief for historic February storms // Los Angeles Times  Ballot measure for America’s highest wage could be victim of past wins // Politico Prop. 22 gains liberal support as case heads to state high court // San Francisco Chronicle PG&E customers were billed for a TV promo campaign // The Sacramento Bee Google blocks some CA news as fight over online journalism bill escalates // Politico Bill to mandate ‘science of reading’ in CA classrooms dies // EdSource CA abortions increased after Roe vs. Wade was overturned // Los Angeles Times The first high-speed rail trains are closer to coming to CA // San Francisco Chronicle Environmental concerns raised by rocket flights // The San Diego Union-Tribune SF jails lock down after alleged assaults on staff // Los Angeles Times SF background check startup Checkr cutting 260 jobs // San Francisco Examiner SF $2B Central Subway has lots of leaks, few riders // The San Francisco Standard Kern County activist faces 18 felony counts over alleged threats // Los Angeles Times Former Windsor mayor’s accusers speak out on no charges // San Francisco Chronicle

California is struggling to provide maternal health for its residents. But as one proposal aims to prevent birth defects, another has received hateful pushback that’s been condemned by both political parties. As CalMatters health reporter Ana B. Ibarra writes, Assemblymember Joaquin Arambula has introduced a bill that would require corn masa flour makers to add […]

A premature baby in incubator. Photo via iStock
A premature baby in incubator. Photo via iStock
A premature baby in incubator. Photo via iStock

California is struggling to provide maternal health for its residents. But as one proposal aims to prevent birth defects, another has received hateful pushback that’s been condemned by both political parties.

As CalMatters health reporter Ana B. Ibarra writes, Assemblymember Joaquin Arambula has introduced a bill that would require corn masa flour makers to add 0.7 milligrams of folic acid per pound of flour. Though federal law requires other grain products, such as cereals, breads and pasta, be fortified with folic acid, corn masa flour is not included. The corn flour is a key ingredient used in many classic Latino foods.

  • Arambula, a Fresno Democrat and physician, to CalMatters: “Food is the best way that we can get folic acid into our communities before they’re pregnant. Oftentimes the prenatal vitamins that we give to pregnant people are too late.” 

Research has shown that folic acid, which can be found in prenatal and women’s multi-vitamins, promotes healthy cell growth, and can prevent birth defects when taken before and during the early weeks of pregnancy. Since 1998, when the U.S. Food and Drug Administration handed down the requirement, the proportion of babies born with neural tube defects dropped by 35%.

But between 2017 and 2019, only about 28% of Latinas reported taking folic acid the month before becoming pregnant, compared to 46% of white women. Women on Medi-Cal, the state’s health insurance program for low-income families, are also less likely to take folic acid before pregnancy compared to women on private insurance. 

To learn more about the proposal, read Ana’s story.

Another bill related to maternal health, Assembly Bill 2319, was the subject of a racist letter sent to members of the Health Committee, according to lawmakers.

The measure would require healthcare providers to undergo training for implicit bias, and for the training to include “recognition of intersecting identities.” 

The bill’s co-author, Assemblymember Lori Wilson, said the letter was “vile and hateful.”

Assembly Republicans also said the letter had no place in legislative debate: “While we may not always agree on policy, we are united to strongly condemn racism and the evil ideology behind this letter.”

Wilson, a Suisun City Democrat who is chairperson of the Legislative Black Caucus, vowed to carry on with the measure.

The proposals by Arumbula and Wilson follow state data showing that in 2020 California saw a ten-year high of pregnancy-related deaths. Black expectant mothers are particularly vulnerable: They are three times more likely to die of pregnancy-related complications than others. It’s a point raised by former state Senate leader Toni Atkins in a social media post last week.

Meanwhile, maternity wards across the state are closing, creating “maternity care deserts,” and California midwives treating Medi-Cal patients struggle to keep their businesses afloat. A February report from the state auditor also found that state health departments failed to track the effectiveness of a perinatal care program for Medi-Cal patients.


Digital Democracy: CalMatters has launched Digital Democracy, a project using the latest technologies to help Californians understand their state government and create more accountability for politicians. The website introduces each of the state’s 120 legislators and explains this year’s policy agenda. In our unprecedented database, you can instantly find any word uttered in a public hearing, every vote cast, every bill introduced and every dollar donated. For more details, see our about and methodology pages and read more from our engagement team.


Other Stories You Should Know


Builders can challenge impact fees

New housing construction in a neighbourhood in Elk Grove on July 8, 2022. Photo by Rahul Lal, CalMatters

From CalMatters housing reporter Ben Christopher:

It’s about to get more difficult for local governments to slap construction projects with certain fees — and a bit easier for developers to sue governments when they do. 

That’s thanks to a unanimous ruling the U.S. Supreme Court handed down Friday.

As many court watchers expected, the justices sided with George Sheetz, a septuagenarian retiree who sued El Dorado County over a $23,420 building fee.

Sheetz’s lawyers argued that the county should have had to prove that this five-digit fee matched the cost that his manufactured home actually would inflict on local roads and highways. That requirement was established in a four-decade-old court ruling also out of California.

El Dorado County, with the backing of both the Gov. Gavin Newsom and President Joe Biden administrations, countered that such a high bar is only required of one-off fees levied by regulators, not fees scheduled for all developments and established by elected bodies, like the county board of supervisors.

In its 9-0 ruling, the Supreme Court said that “there is no basis for affording property rights less protection in the hands of legislators than administrators.”

A few possible consequences of the ruling:

  • Cities and counties now have to show that impact fees are connected to and “roughly proportionate” to the fiscal impact of a given development. That could have the unintended consequence of slowing down permitting. 
  • Developers may now have a powerful new legal tool to challenge fees that they think are too high.

And they are high here. As of 2015, the average impact fee on a single family home in California was more than four times the national average.

But it’s too soon to say exactly how all of this will shake out. That’s because the court stopped short of saying exactly how far governments have to go to justify their fees — or whether El Dorado County already cleared that hurdle in this case. Those questions were left to lower courts.

State cracks down on water

The water treatment facility in Armona on April 4, 2024. Armona, a small unincorporated community home to farmworkers in Kings County, had substantial arsenic contamination until a new $9 million well was installed more than 1,200 feet deep. Photo by Larry Valenzuela, CalMatters/CatchLight Local
Armona’s new $9 million well and treatment facility to remove arsenic in its water supply. Photo by Larry Valenzuela, CalMatters/CatchLight Local

The State Water Resources Control Board is poised to penalize Kings County groundwater agencies for failing to manage overpumping in the region’s water supply — a move that would set a new precedent.

As CalMatters water reporter Rachel Becker explains, the board on Tuesday is expected to decide whether to put county agencies on probation for unsuccessfully restricting farmers’ overdrafting of the water supply from the Tulare Lake underground basin. If the board decides to crack down, it will be the first time the state imposes penalties under a landmark 2014 law that requires agencies to achieve groundwater sustainability by 2040.

The board’s decision could also signal how the state will approach five other overpumped San Joaquin Valley basins that may face probation as well.

Overpumping in Kings County has caused household and community water wells to dry up and land to sink, which endangers canals, aqueducts and flood-controlling levees. And because wells must reach deeper into the ground to extract water, contaminants such as arsenic are released and cause water contamination levels to rise.

Putting Kings County agencies on probation could mean imposing state fees totaling as much as $10 million a year, according to a CalMatters analysis. It could also lead to state regulators eventually managing the region’s groundwater.

This has small farmers in the region concerned that they’ll be forced out of business due to the state’s steep fees. The basin provides drinking and irrigation water for 146,000 residents and supports a multibillion-dollar agricultural industry.

For more on this issue, read Rachel’s story.

California’s water crisis, explained: CalMatters has a detailed look at how California might increase its water supply, and a dashboard tracking the state’s water situation.


CalMatters Commentary

Ideas festival: CalMatters is hosting its first one, in Sacramento on June 5-6. It will include a discussion on broadband access and a session with Zócalo Public Square on California’s next big idea. Featured speakers include Julián Castro, CEO of the Latino Community Foundation, and Barbara McQuade, a former U.S. attorney and MSNBC legal analyst. Find out more from our engagement team and buy tickets here.


Other things worth your time:

Some stories may require a subscription to read.


CA granted federal disaster relief for historic February storms // Los Angeles Times 

Ballot measure for America’s highest wage could be victim of past wins // Politico

Prop. 22 gains liberal support as case heads to state high court // San Francisco Chronicle

PG&E customers were billed for a TV promo campaign // The Sacramento Bee

Google blocks some CA news as fight over online journalism bill escalates // Politico

Bill to mandate ‘science of reading’ in CA classrooms dies // EdSource

CA abortions increased after Roe vs. Wade was overturned // Los Angeles Times

The first high-speed rail trains are closer to coming to CA // San Francisco Chronicle

Environmental concerns raised by rocket flights // The San Diego Union-Tribune

SF jails lock down after alleged assaults on staff // Los Angeles Times

SF background check startup Checkr cutting 260 jobs // San Francisco Examiner

SF $2B Central Subway has lots of leaks, few riders // The San Francisco Standard

Kern County activist faces 18 felony counts over alleged threats // Los Angeles Times

Former Windsor mayor’s accusers speak out on no charges // San Francisco Chronicle

Read the full story here.
Photos courtesy of

Gas stove makers quietly delete air pollution warnings as they fight mandatory health labels

Manufacturers sued to stop a Colorado law requiring air quality warnings, arguing gas stoves are safe. Some of their websites once said the opposite.

The home appliance industry would like you to believe that gas-burning stoves are not a risk to your health — and several companies that make the devices are scrambling to erase their prior acknowledgements that they are.  That claim is at the heart of a lawsuit the Association of Home Appliance Manufacturers has filed against the state of Colorado to stop it from requiring natural gas stoves, which burn methane, to carry health labels not unlike those on every pack of cigarettes. “Understand the air quality implications of having an indoor gas stove,” the warning would read. The law was to take effect August 5 but is now on hold, and state officials did not respond to a request for comment. In its federal lawsuit, the Association — whose board includes representatives of LG Electronics, BSH Home Appliance Corp. (which makes Bosch appliances), Whirlpool, and Samsung Electronics — asserts that the labeling requirement is “unconstitutional compelled speech” and illegal under the First Amendment. It calls the legislation a climate law disguised as a health law and, most strikingly, it claims there is “no association between gas stoves and adverse health outcomes.”  Yet LG, BSH, Whirlpool, and Samsung have published information on their websites directly contradicting that claim and lauded the health benefits of electric and induction stoves.  “Traditional gas appliances can emit harmful pollutants, which can compromise indoor air quality and pose health risks,” reads a blog post, titled “Life’s Good When It’s Electrified,” that LG published in May of 2024. “By switching to electric appliances, these risks are substantially reduced, ensuring a cleaner and safer home environment.”  Another LG page noted that “induction surfaces remain cool to the touch and unlike gas, is better for kitchen air quality” as recently as May 25, according to an archived version of the site maintained by Wayback Machine. It was later revised to eliminate mention of gas, reading “Surfaces remain cool to the touch — no open flames or hot coils. No fumes, either, so it’s [sic] air quality-friendly.” BSH’s page on Bosch induction cooktops notes that the devices are “safer to use because unlike other types of cooktops, they do not release indoor air pollutants during cooking.” Whirlpool wrote that induction cooktops might help “reduce indoor air pollutants.”  And until last week, a page on Samsung’s U.S. website said “induction cooktops can … help remove concerns over indoor air pollution, creating a sustainable and healthier home environment. The page’s source code did not appear to have been updated since 2022. Samsung did not respond to multiple requests for comment, but the page was taken down shortly after Grist reached out to the company.  Itai Vardi, a researcher with the Energy and Policy Institute, was the first to notice the discrepancies between what the Association said in its lawsuit and what some of its manufacturers have said in the past. “The statements coming from them directly contradict the very strong language in this lawsuit,” Vardi said. “And that, I think, deserves some scrutiny.” Scientific evidence that gas stoves pollute by releasing dangerous concentrations of nitrogen dioxide, benzene, and methane has accumulated since 1970. Justin Paget / Getty Images In its lawsuit, the Association argues that “the potential health risks of cooking with gas are no different than cooking with electricity” and acknowledging the ways gas-burning appliances can harm respiratory health promotes “non-consensus, scientifically controversial, and factually misleading” messages. It adds that “there is scant scientific support” for disclosing health risks associated with gas appliances.  Asked for comment, the organization referred to a statement it issued August 6 saying “no study has found that gas stoves cause respiratory health issues.”  When reached for comment, a BSH representative stated that the company is as of now “in complete alignment” with the Association’s position. An LG representative noted that the most pollution-acknowledging statements on their website were in fact made by the company’s UK branch, but did not respond to a follow-up question about whether the UK and US divisions disagree on the risks of LG products. “This is a troubling attempt by these companies’ to quickly erase their own public acknowledgement of the dangers of gas stoves,” said Vardi. “But you can scrub your website, not the fact of gas stove pollution.”  Scientific evidence that gas stoves pollute by releasing dangerous concentrations of nitrogen dioxide, benzene, and methane has piled up for the past half-century. In 1970, scientist Carl Shy showed that families exposed to high levels of nitrogen dioxide indoors are at greater risk of asthma and other respiratory illnesses than those who are not. Nine years later, scientist Bernard Goldstein identified the fuel as the likely source of all that nitrogen. A bevy of studies and papers in the decades since came to similar conclusions. One 2022 study estimated that 12 percent of American children with asthma develop that respiratory condition solely due to living in homes with gas stoves.  Appliance manufacturers and the natural gas industry are no stranger to promoting their products regardless of known health risks. “There’s been a campaign by industry to keep the science under wraps or to confuse it, deny it,” said Abe Scarr of the consumer-protection nonprofit Public Interest Working Group.  The lobbyists at the American Gas Association have worked hard to popularize gas stoves: At one point, the organization even provided the stoves Julia Child used in her popular cooking show. The campaign went beyond product placement: When information on the health risks of gas stoves began to emerge in the mid-1970s, industry lobbyists launched “Operation Attack,” a million-dollar marketing campaign to bring the stoves into even more kitchens. This worked: today, about 40% of Americans cook with gas. They also funded their own research, which cast doubt on independent findings on the health risks of gas stoves.  Environmental health sciences professor Misbath Daouda of the University of California, Berkeley, was recently part of a pilot study replacing gas stoves in low-income New York City apartments with induction stoves. Nitrogen dioxide concentrations in those apartments, she said, dropped by over 50 percent within months – and the families who lived there liked their new cooktops better than the old ones, she said.  The association between gas stoves and adverse health outcomes, Daouda said, “is clear.”  “I’m not sure who they are referring to when they say the majority of studies” don’t support that conclusion, she said. This story was originally published by Grist with the headline Gas stove makers quietly delete air pollution warnings as they fight mandatory health labels on Sep 17, 2025.

New Biomarker Could Detect Alzheimer’s Years Before Symptoms Appear

TSPO levels rise early in Alzheimer’s and persist throughout disease. Targeting this biomarker could open new treatment options. TSPO, a major marker of brain inflammation, may offer a way to detect Alzheimer’s disease long before memory problems and other symptoms develop. Findings published in Acta Neuropathologica suggest it could transform both diagnosis and treatment strategies. [...]

A new study suggests that TSPO, a key biomarker of brain inflammation, may reveal the earliest stages of Alzheimer’s disease long before symptoms appear. Credit: StockTSPO levels rise early in Alzheimer’s and persist throughout disease. Targeting this biomarker could open new treatment options. TSPO, a major marker of brain inflammation, may offer a way to detect Alzheimer’s disease long before memory problems and other symptoms develop. Findings published in Acta Neuropathologica suggest it could transform both diagnosis and treatment strategies. “This is the first study to really examine how early this biomarker increases and where it begins rising in the brain,” said Tomás R. Guilarte, lead researcher and dean of FIU’s Robert Stempel College of Public Health & Social Work. “If we can use this information to help delay Alzheimer’s progression by even five years, it can drastically improve patients’ lives and reduce disease prevalence.” Longstanding research on TSPO Guilarte, a recognized authority on TSPO (translocator protein 18 kDa), has investigated the protein for more than 30 years. His research helped establish it as a dependable imaging marker for identifying neuroinflammation across multiple neurological, neurodegenerative, and psychiatric conditions. Researchers Daniel Martínez Pérez (L) and Dr. Tomás R. Guilarte (R) in the Brain, Behavior and the Environment Laboratory at Florida International University. Guilarte and Martínez Pérez published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International UniversityFor the current study, Guilarte and colleagues applied advanced imaging techniques to track TSPO activity in genetically engineered mouse models of familial Alzheimer’s. They then validated these results using donated brain tissue from members of the world’s largest community with early-onset familial Alzheimer’s, based in Antioquia, Colombia. These families carry the “paisa” mutation, first identified by the late Dr. Francisco Lopera, a co-author of the study who spent his career searching for ways to prevent Alzheimer’s. Individuals with this genetic variant often develop symptoms in their 30s or 40s and typically die in their 50s. L: The original cell image. R: The same cell image zoomed in and rendered in the special imaging software. Microglia (blue) signaling TSPO (red) are clustered around plaques (cyan). Researchers at Florida International University published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in.  Credit: Chris Necuze, Florida International UniversityEarly changes in the hippocampus In the mouse model, researchers detected elevated TSPO levels in the subiculum – a critical part of the hippocampus – as early as six weeks of age, roughly equivalent to age 18–20 in humans. Microglia, the brain’s main immune cells, specifically those clustered around amyloid plaques, had the highest levels of TSPO. Notably, female mice had higher TSPO levels, mirroring real-world statistics: two-thirds of Alzheimer’s patients are women. Daniel Martínez Pérez holds tissue sample. Martínez Pérez, a researcher in Florida International University’s Robert Stempel College of Public Health & Social Work, is the first author of a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International UniversityThe brain tissue samples from the Colombian patients with the paisa mutation showed the same pattern. Even in late-stage Alzheimer’s, TSPO remained high in microglia near plaques. These results raise new questions about TSPO’s function – whether it contributes to damage or protects the brain – and whether blocking or enhancing it could halt disease progression. Next steps in research The team is now working with a specially developed Alzheimer’s mouse model lacking TSPO to explore these questions further. They’re also expanding the study to include sporadic, late-onset Alzheimer’s cases, the form that accounts for over 90% of all diagnoses. Researchers Dr. Tomás R. Guilarte (L) and Daniel Martínez Pérez (R) in the Brain, Behavior and the Environment Laboratory at Florida International University. Guilarte and Martínez Pérez published a study that found TSPO, a key biomarker of brain inflammation, could help detect Alzheimer’s disease years before memory loss and other symptoms set in. Credit: Chris Necuze, Florida International University“The more we understand these processes,” said Daniel Martínez Pérez, first author and Ph.D. candidate in Guilarte’s lab, “the closer we get to tailoring treatments that can truly help – before it’s too late.” Reference: “Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer’s disease” by Daniel A. Martinez-Perez, Jennifer L. McGlothan, Alexander N. Rodichkin, Karam Abilmouna, Zoran Bursac, Francisco Lopera, Carlos Andres Villegas-Lanau and Tomás R. Guilarte, 17 July 2025, Acta Neuropathologica.DOI: 10.1007/s00401-025-02912-4 This work was supported by grants ES007062-24 to T.R.G. from the National Institute of Environmental Health Sciences (NIEHS), ES007062-23S1 to T.R.G. from the National Institute on Aging, and T32-ES033955 to A.N.R. from the NIEHS. Never miss a breakthrough: Join the SciTechDaily newsletter.

Living Near Polluted Missouri Creek as a Child Tied to Later Cancer Risk

By I. Edwards HealthDay ReporterTHURSDAY, July 17, 2025 (HealthDay News) — Folks who grew up near a polluted Missouri creek during the 1940s...

THURSDAY, July 17, 2025 (HealthDay News) — Folks who grew up near a polluted Missouri creek during the 1940s through 1960s may have higher odds for cancer now, new research shows.The study focused on Coldwater Creek in St. Louis County. The area was contaminated with radioactive waste from the U.S. government’s atomic bomb program during World War II.Back then, uranium was processed in St. Louis and nuclear waste was stored near the city’s airport. That waste leaked into Coldwater Creek, which runs through several residential neighborhoods.Researchers found that people who lived within one kilometer (0.62 miles) of the creek as kids had an 85% higher risk of developing certain cancers later in life compared to those who lived more than 20 kilometers (12.4 miles) away.Those cancers include leukemia, thyroid cancer and breast cancer, which are known to be linked to radiation exposure.“The closer the childhood residence got to Coldwater Creek, the risk of cancer went up, and pretty dramatically," lead researcher Marc Weisskopf, a professor of epidemiology at Harvard T.H. Chan School of Public Health, told The Wall Street Journal.For the study, Weisskopf’s team surveyed more than 4,200 adults who lived in the St. Louis area as children between 1958 and 1970.These people had donated their baby teeth years ago for radiation research. The new survey asked about cancer and other health issues.About 1 in 4 participants said they had been diagnosed with cancer. Risk dropped the farther someone lived from the creek as a child.Outside experts who reviewed the findings described them as concerning.“It emphasizes the importance of appreciating that radioactive waste is carcinogenic, particularly to children, and that we have to ensure that we have to clean up any remaining waste that’s out there,” Dr. Rebecca Smith-Bindman, a radiation risk expert at the University of California, San Francisco, told The Journal.In 2024, the U.S. Army Corps of Engineers began placing warning signs along parts of the creek that still have radioactive waste, The Journal reported.The U.S. Agency for Toxic Substances and Disease Registry reported in 2019 that contamination have raised the risk of leukemia and lung and bone cancer. Later exposures, starting in the 2000s, were linked to a slight increase in lung cancer for those who lived nearby.But the agency said it’s hard to link any one person’s cancer directly to radiation. Genetics, lifestyle and other factors could also play a role.In this study, radiation exposure wasn’t directly measured. Cancer cases were also self-reported, not confirmed by medical records. Weisskopf plans to measure radiation levels using the stored baby teeth in future research.Radiation exposure has long been tied to cancer, but this study is among the first to look at lower, long-term environmental exposure in the U.S., not just high levels from nuclear disasters or bombings."Radiation, when it’s given unnecessarily, only causes risk," Dr. Howard Sandler, chair of radiation oncology at Cedars-Sinai in Los Angeles, told The Journal.SOURCE: The Wall Street Journal, July 16, 2025Copyright © 2025 HealthDay. All rights reserved.

Disposable Vapes Release Toxic Metals, Lab Study Says

By Dennis Thompson HealthDay ReporterFRIDAY, July 11, 2025 (HealthDay News) — People using cheap disposable vape devices are likely inhaling high...

By Dennis Thompson HealthDay ReporterFRIDAY, July 11, 2025 (HealthDay News) — People using cheap disposable vape devices are likely inhaling high levels of toxic metals with every puff, a recent study says.After a few hundred puffs, some disposable vapes start releasing levels of toxic metals higher than found in either last-generation refillable e-cigarettes or traditional tobacco smokes, researchers reported in the journal ACS Central Science.These metals can increase a person’s risk of cancer, lung disease and nerve damage, researchers said.“Our study highlights the hidden risk of these new and popular disposable electronic cigarettes — with hazardous levels of neurotoxic lead and carcinogenic nickel and antimony — which stresses the need for urgency in enforcement,” senior researcher Brett Poulin, an assistant professor of environmental toxicology at the University of California-Davis, said in a news release.Earlier studies found that the heating elements of refillable vapes could release metals like chromium and nickel into the vapor people breathe.For this study, researchers analyzed seven disposable devices from three well-known vape brands: ELF Bars, Flum Pebbles and Esco Bar.Before they were even used, some of the devices had surprisingly high levels of lead and antimony, researchers reported. The lead appears to have come from leaded copper alloys used in the devices, which leach into the e-liquid.The team then activated the disposable vapes, creating between 500 and 1,500 puffs for each device, to see whether their heating elements would release more metals.Analysis of the vapor revealed that:Levels of metals like chromium, nickel and antimony increased as the number of puffs increased, while concentrations of zinc, copper and lead were elevated at the start. Most of the tested disposables released higher amounts of metals than older refillable vapes. One disposable released more lead during a day’s use than one would get from nearly 20 packs of tobacco cigarettes. Nickel in three devices and antimony in two devices exceeded cancer risk limits. Four devices had nickel and lead emissions that surpassed health risk thresholds for diseases other than cancer. These results reflect only three of the nearly 100 disposable vape brands now available on store shelves, researchers noted.“Coupling the high element exposures and health risks associated with these devices and their prevalent use among the underage population, there is an urgent need for regulators to investigate this issue further and exercise regulatory enforcement accordingly,” researchers wrote.SOURCES: American Chemical Society, news release, June 20, 2025; ACS Central Science, June 25, 2025Copyright © 2025 HealthDay. All rights reserved.

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