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The most innovative companies in applied AI for 2025

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Tuesday, March 18, 2025

It’s been gradual, but generative AI models and the apps they power have begun to measurably deliver returns for businesses. Organizations across many industries believe their employees are more productive and efficient with AI tools such as chatbots and coding assistants at their side. Numerous AI startups found traction offering such solutions during 2024. Glean, for example, puts cutting-edge AI search capabilities in the hands of employees so that they can tap into various apps and platforms to find documents and corporate intelligence. Contextual AI lets organizations put a company’s proprietary intelligence into a secure data store, then lets them build AI apps that can call on that data. Enterprises are also using AI apps to protect softer corporate assets, such as reputation. Blackbird.AI offers a web app that enterprises use to monitor how their brand name is portrayed in social media posts, videos, links, and memes. Other standout AI apps focuse on specific industries. Google DeepMind put drug discovery ahead by years when it improved on its AlphaFold model, which now can model and predict the behaviors of proteins and other actors within the cell. Harvey has found its legs within the legal industry by offering an AI legal assistant that can write briefs, summarize and compare cases, and more. Coding assistants grew considerably–both in capability and usage–during 2024. Anysphere’s Cursor tool, for example, helped advance the genre from simply completing lines or sections of code to building whole software functions based on the plain language input of a human developer.1. GleanFor arming employees with the tools to get their jobs doneCompanies contain a lot of information that’s crucial for employees to know, but it’s spread out across an array of workplace apps: Slack, Microsoft 365, Google Workspace, Salesforce, and more. Five-year-old Glean offers a user-friendly AI-powered search tool that allows employees to find information and generate answers across more than 100 data sources.In June 2024, the company transformed its existing enterprise AI assistant and search engine into a platform called Work AI platform. It allows employees of all technical backgrounds to quickly generate personalized, accurate answers—and even create their own no-code tools to make the agents work better for the specifics of their jobs and businesses. The Work AI suite also includes a Glean Actions tool, which enables the AI assistant to directly take action on an employee’s behalf within a company’s connected applications. Actions could involve reading data from an application and executing a specific task, creating Jira tickets, publishing new content, or searching for code.In September, Glean doubled down on its user-friendly proposition by making it even easier for non-technical employees to get the most from its tools with next-generation prompting features. These features include a Prompt Builder feature, which allows users to create their own directives for the AI assistant, and a Prompt Library, which includes suggested prompts from Glean, as well ones that a company has shared in its own prompt library.According to a November 2024 report in The Information, Glean was generating around $100 million in annual recurring revenue, more than tripling that metric over the past year. The company closed two funding rounds in 2024: $200 million in February and $260 million in September at a $4.6 billion valuation. Its 200+ customers include Reddit, Instacart, Pinterest, Duolingo, and Databricks.Read more about Glean, honored as No. 6 on Fast Company’s list of the World’s 50 Most Innovative Companies of 2025.2. AnysphereFor giving developers a coding partner with contextual awarenessCursor AI has emerged as a standout in the growing field of AI code editors. The company behind it, Anysphere, made the smart design choice of building the UX based on Microsoft’s Visual Studio Code, a familiar programming environment. Cursor also can access a developer’s or company’s existing code base as a way of fine-tuning code suggestions.Cursor acts like a coding partner that’s aware of the context in which code is being created. It offers code auto-completions, and not just of single lines–it can generate entire sections of code, and then explain the reasoning behind them. Or the developer can explain a new feature or function in plain language and the AI will code a prototype of it.Anysphere says Cursor now has more than 40,000 customers. Developers in online forums say that after using Cursor, they can’t go back to GitHub Copilot. In August, the startup raised a $60 million A round at a $400 million valuation from Andreessen Horowitz, Thrive Capital, OpenAI, Google’s Jeff Dean, OpenAI’s Noam Brown, and the founders of Stripe, GitHub, Ramp, and Perplexity. Four months later it raised a Series B round that closed in January 2025 with $105 million invested, raising its valuation to $2.6 billion.Read more about Anysphere, honored as No. 26 on Fast Company’s list of the World’s 50 Most Innovative Companies of 2025.3. Blackbird.AIFor arming NATO and others with AI that detects AI disinformationBusinesses and other organizations must constantly be aware of how their name is being used in the digital environment, and be able to react quickly if their brand and reputation are distorted by misinformation or disinformation. In 2024 Blackbird.AI released its Compass platform, which lets individual users reality check or get greater context around suspicious claims made in social media posts, videos, links, or memes. The user pastes the content into the Compass tool, which checks it against thousands of trustworthy online sources.In October 2024 Blackbird.AI launched “Compass Vision,” a new AI-based tool for identifying AI deepfake images and videos. Customers can access Compass Vision directly through Blackbird.AI’s platform, or they can use its API to integrate it with their existing threat intelligence and social listening systems. As companies continue to more aggressively protect their market value and brand equity in the digital space, the market for “narrative intelligence” services is likely to grow to as much as $70 billion annually, Blackbird.AI believes. The company has already positioned itself well, and expects its revenues to double or triple over the next year. Blackbird.AI has raised more than $20 million in venture capital so far.4. Google DeepMindFor unfolding the mysteries of structural biochemistryGoogle DeepMind CEO Demis Hassabis and director of research John Jumper won the 2024 Nobel Prize in Chemistry for their parts in discovering and developing the AlphaFold AI models, which can predict the complex structures of virtually all known proteins. Proteins control and drive all chemical reactions within the bodies of organisms, including humans, so the tool is of great interest to researchers in drug development, material science, and environmental science.In 2024 DeepMind expanded its AlphaFold AI system to model how proteins interact with other cell structures, including DNA, RNA, and small molecules that are often used in drugs. The new system, called AlphaFold 3, can model the ways in which proteins “read” our DNA and then carry out the instructions in the body. It lets drug researchers quickly model how new drug compounds might react with certain receptor sites in the body, which could accelerate the exploratory phase of drug development. Traditionally this work has been done experimentally, in a wet lab. Google DeepMind developed AlphaFold 3 in collaboration with London-based Isomorphic Labs, an AI-based drug discovery lab it spun out into an independent unit within Google parent company Alphabet. Isomorphic is now working with Novartis and Eli Lilly. While drugs based on AlphaFold’s breakthroughs are yet to come, it’s already instigated a revolution in structural biochemistry.5. DeepLFor translating everyday business communications into 33 languages, including traditional Chinese and ArabicFast and accurate translation are crucial for multinational corporations, and generative AI has been a natural complement to existing services. One service provider, DeepL, has emerged as a standout for the accuracy and cost-effectiveness of its AI. The company already serves more than 150,000 businesses, governments, and other organizations across the legal, tech, media, manufacturing, and retail industries, including known names such as Nikkei, Panasonic Connect, Zendesk, and Morningstar.In November 2024 the company released DeepL Voice for Meetings, which lets participants speak in their preferred language during meetings and video calls, with real-time captions of others’ comments in their chosen language. DeepL Voice for Conversations does the same thing, but for one-on-one conversations happening on mobile devices. In July 2024, DeepL deployed a new large language model of its own, which its says significantly outperforms LLMs from OpenAI, Google, and Microsoft for translation. DeepL also added Traditional Chinese and Arabic languages to its platform, bringing total supported languages to 33. Beyond translation, DeepL launched a new tool called DeepL Write, designed to help professionals improve their business writing skills.In May 2024 DeepL raised a $300 million funding round and saw its valuation rise to $2 billion–doubling its valuation after its previous funding round a year earlier.6. PerplexityFor turning generative AI into a rival to traditional search, especially for election coveragePerplexity is one of the biggest success stories of the current AI boom. Its “answer engine” has revitalized web search, using a combination of homegrown large language models (LLMs), third-party models (from OpenAI, Anthropic, DeepSeek and others) and web crawlers to return custom answers that are highly relevant and fastidiously cited. The San Francisco-based company saw its user base grow throughout 2024, as it added new features and functions to its platform. Perplexity began experimenting with ads and referrals on its platform late in 2024, and launched “Shop like a Pro”, an AI-powered shopping assistant that lets users research and even purchase products within Perplexity. Users of the Perplexity mobile app users can even snap pictures of items to see related products and buying information.Perplexity’s most surprising creation during 2024 may have been the AI-powered Election Information Hub it launched before the November 2024 U.S. elections. The hub offered voters real-time updates, candidate information, and ballot measure summaries, along with AI-generated analysis based on reliable data from The Associated Press and Democracy Works. Perplexity’s clear, verifiable approach to election coverage gained significant attention during the run-up to the elections.7. Contextual AIFor making the next generation of AI more accurate and efficientTo avoid hallucinations and keep answers on point, AI developers use what’s called retrieval-augmented generation (RAG), where large language models are fed relevant information used to respond to specific queries. Cofounded by CEO Douwe Kiela, who pioneered RAG while at Meta, Contextual AI emerged from stealth mode in June 2023 with a mission to use the power of RAG to build more accurate LLMs for enterprises.In March 2024, the company introduced RAG 2.0, a system that trains LLMs and the RAG ystem together, resulting in Contextual Language Models that are tuned for specific purposes for which they outperform leading commercial and open source models. Contextual also worked with the Allen Institute for Artificial Intelligence to develop OLMoE, an AI system introduced in September that uses an approach called “mixture of experts,” in which a specialized subsection of the model is called on to answer a given question, leaving most of the other model parameters at rest. This can increase a model’s accuracy while making it faster and more energy efficient.Contextual, which counts HSBC, Qualcomm and The Economist as customers, announced in August 2024 that it raised an $80 million Series A round to fund further development of its enterprise-grade AI systems.8. HarveyFor giving lawyers a trustworthy AI agentUsing large language models in legal work has long been a tantalizing possibility. But fears over inaccuracies due to AI hallucinations have caused the legal field to move slowly in their adoption of them. Harvey has managed some real innovations aimed at making its AI legal assistant more reliable and transparent about its work. The Harvey Assistant can read and analyze cases and other data faster than a human lawyer or legal assistant, and can draft documents, analyze information, and answer questions about hundreds of complex legal files.Harvey gave the Assistant some important upgrades in August 2024. It added a series of specialized modes tailored to different kinds of legal work, it trained its AI to refine and expand on its initial responses, and it improved the system’s outputs and processing speed. Harvey says the new version of Assistant reduces AI hallucinations by 60% and improves the accuracy of cited sources by 23%. In a move to demystify the way the assistant comes up with its answers, Harvey released a report called “BigLaw Bench” describing its model training and evaluation methodologies.The company more than tripled its employees during 2024, and added more than 100 new customers in 15 countries. With a new $100 million funding round in July 2024, the company saw its valuation rise to $1.5 billion.9. Khan AcademyFor empowering students and their teachers with a free AI writing coachIn 2023, Khan Academy launched Khanmigo, an experimental AI tutor designed to give students one-on-one help in tasks such as practicing math problems, brainstorming project ideas, and analyzing literature. Since then, thousands of students and teachers have started using the tool, and Khan Academy has been busy adding new tools and features to the platform.During 2024, the non-profit built some important new functionality into its Khanamigo Writing Coach, which had originally been designed to act as a writing tutor for students. The tool now helps teachers, too, giving them access to detailed reports on student progress. It generates high-level insights on the writing challenges of individual students, and even helps teachers identify difficulties that multiple students in the class are facing. All this addresses a real challenge in English education–the time constraints teachers face when providing feedback on writing.Khan Academy cites a real-life example of a teacher with 100 students who typically needed 17 hours to review the first drafts of a two-page essay assignment, assuming the teacher spent 10 minutes on each paper. In an era when AI offers to do our writing for us, Khanamigo Writing Coach is instead focused on helping students break through barriers to effective written communication—and on helping teachers guide them along the way.10. SpeakFor supercharging English-language learning with live conversational roleplaysSpeak’s AI English tutor app, which is widely used in Korea and Japan, has been around for years. But the company took a big step forward during 2024 with a little help from OpenAI. The app already offered an English tutor that could teach and converse, but the conversations felt slow and unnatural. That’s because Speak’s system had to transcribe the user’s speech, run it through a text-based LLM workflow, then synthesize the AI character’s speech. Each of these steps created gaps and errors in the back-and-forth, which was disruptive to the learning process.Then Speak became one of the first companies to get access to OpenAI’s Realtime API, using it to power its “Live Roleplays” feature. The Realtime API is unique in that it’s powered by AI that treats both text and voice in the same way–as common tokens within a multi-modal model. So no conversions are necessary, making the model’s response time super-fast.As a result, Speak’s tutor can generate its voice responses with almost no delay. This makes exchanges between student and AI tutor feel much more fluid and natural. And that’s very important, because the best and fastest way to learn another language is through real life conversations. Speak may not be exactly real-life, but with OpenAI’s help it’s a lot closer to real-time.11. PikaFor making a state-of-the-art video generator that’s accessible to nonprofessionalsPika’s founders, Demi Guo and Chenlin Meng, dropped out of Stanford’s artificial intelligence PhD program in 2023 to pursue a big idea. The world needed a world-class video generation app that was designed for regular people–not just professional creators, film-makers and AI early adopters.The duo and their new company got the attention of the AI industry with the release of the second version of their model, Pika 1.5, and the accompanying app, in September 2024. People soon began pumping out videos using the app’s motion control and effects such as Pikaffects, with which users can melt, inflate, crush, squish or explode pretty much anything. This unleashed a wave of videos that were perfect for social media sites like TikTok.In December 2024, the company dropped its Pika 2.0 model, which introduced the ability to dress up videos with people, objects, and places from photos they upload to the app. Just a month later, it launched its 2.1 model, which added an Advanced Motion Control feature, which made animation or high-motion video more fluid and natural-looking.Pika is still a very young company, but it’s already taken a place in the top tier of AI video generators, along with OpenAI’s Sora, Runway’s Gen-3 Alpha, and Google’s Veo.12. CanvaFor bringing Gen AI design to the largest organizationsCanva has the most popular app in the design and creative category, with more than 100 million downloads in the Google Play store alone. The company has been busily adding AI features to its app, and many of its users are embracing them. In 2024, Canva continued expanding its Magic Studio suite of AI tools. The suite, which is aimed at designers within organizations big and small, now includes 12 native AI products built on proprietary models from Canva and its partners, including OpenAI, Google and Runway. They include a “text to graphic” generation tool, AI photo editing, and a feature that assembles a highlight reel of the best clips from a longer video.Canva also strengthened its AI hand in 2024 by acquiring Leonardo.Ai, a generative AI platform specializing in image and video that’s used by 19 million creatives globally. Canva was quick to begin powering its own new features using Leonardo’s powerful Phoenix foundation model, starting with the new Dream Lab image generator it launched in October. Canva did meet with some backlash when it raised the prices of its Teams plans because of the new AI features. Still, Canva it says its growth has continued to accelerate, reaching 220 million monthly active users by year-end, the last 20 million of those added in the fourth quarter alone.13. SalesforceFor letting customers design no-code AI agents that can handle customer service, marketing, and moreSalesforce moved rapidly to embrace AI agents during 2024, pivoting from its former “Einstein” AI platform to Agentforce, a new platform that lets Salesforce customers design their own no-code agents to handle customer service, sales, marketing, scheduling and other tasks. Agents go beyond chatbots by being able to perform work-related tasks without the constant supervision of humans. They can, for example, analyze data, make decisions, and work through tasks step by step on the user’s behalf.For example, Salesforce offers an agent called Sales Development Representative (SDR) that can engage with sales prospects at any time of the day, answer questions, schedule sales meetings, and even manage objections. In the second half of 2024 Salesforce released two major versions of the Agentforce platform. The vision is big—agents could be as significant a shift for business software as the move to the cloud 25 years ago—and while it’s still early, the first adopters of the technology include some big names, such as Disney, OpenTable, Saks Fifth Avenue, and Wiley.On an early December earnings call, Salesforce CEO Marc Benioff said his company is “unleashing this new era of digital labor for every business and industry.” He added that even though the Agentforce platform had only been available since late October, his company had already “signed 200 deals” to give companies access.14. OsmoFor teaching AI how to smellThe startup Osmo, which was spun out of Google Research in 2022, has developed a way of giving AI the sense of smell. The company–which is backed by Google Ventures, Lux Capital, and the Bill & Melinda Gates Foundation–developed an AI system that can identify and recreate odors. It uses a number of sensitive sensors to detect molecules in the air that create odors, then feeds the sensor data to its AI models, which can represent the molecules digitally, as tokens within a neural network. The system can also create totally new scents, such as might be used in perfumes.Beyond the obvious application in the fragrance industry, Osmo has already tested its system for the detection of counterfeit goods, which usually have a very different olfactory signature than legit products. From July through September of 2024, Osmo deployed its system of sensors and models for four weeks at a fulfillment center for an online marketplace, where it gave hundreds of boxes of shoes the smell test. In the end Osmo proved there to be a measurable smell difference between authentic and counterfeit shoes, and that its system can ID the fakes quickly and accurately. It’s likely that many meaningful applications for Osmo’s AI haven’t yet been realized, such as in security work, disease detection or–you guessed it–Smell-o-vision.15. EvolutionaryScaleFor applying AI to design new proteins that the world needsEvolutionaryScale is an AI company that develops advanced artificial intelligence models for biological research, particularly focusing on proteins. The company’s main product is ESM3, an generative AI model for biology that can reason over the sequence, structure, and function of proteins. ESM3 can be used to generate new protein designs that would take millions of years to evolve in nature, and that can be realized through synthetic biology methods, the company says. Such proteins could be useful in environmental science and materials science. In 2024 ESM3 generated a new Green Fluorescent Protein (GFP), a type of protein responsible for the glowing effect seen in jellyfish and the vibrant fluorescent colors of coral. As a result of its unique properties, GFP has become an important tool in molecular biology, helping scientists to see molecules inside cells. EvolutionaryScale also published a paper in Nature that detailed how a team of scientists utilized a variant model called ESMFold to unveil deep and distant evolutionary relationships within the flavivirus family, which includes viruses such as hepatitis C, dengue, and Zika. In 2024 the company raised a $142 million round from noted AI investors Nat Friedman and Daniel Gross, along with Lux Capital, Amazon, and Nvidiz’s venture capital arm, and others.Explore the full 2025 list of Fast Company’s Most Innovative Companies, 609 organizations that are reshaping industries and culture. We’ve selected the companies making the biggest impact across 58 categories, including advertising, applied AI, biotech, retail, sustainability, and more.

It’s been gradual, but generative AI models and the apps they power have begun to measurably deliver returns for businesses. Organizations across many industries believe their employees are more productive and efficient with AI tools such as chatbots and coding assistants at their side. Numerous AI startups found traction offering such solutions during 2024. Glean, for example, puts cutting-edge AI search capabilities in the hands of employees so that they can tap into various apps and platforms to find documents and corporate intelligence. Contextual AI lets organizations put a company’s proprietary intelligence into a secure data store, then lets them build AI apps that can call on that data. Enterprises are also using AI apps to protect softer corporate assets, such as reputation. Blackbird.AI offers a web app that enterprises use to monitor how their brand name is portrayed in social media posts, videos, links, and memes. Other standout AI apps focuse on specific industries. Google DeepMind put drug discovery ahead by years when it improved on its AlphaFold model, which now can model and predict the behaviors of proteins and other actors within the cell. Harvey has found its legs within the legal industry by offering an AI legal assistant that can write briefs, summarize and compare cases, and more. Coding assistants grew considerably–both in capability and usage–during 2024. Anysphere’s Cursor tool, for example, helped advance the genre from simply completing lines or sections of code to building whole software functions based on the plain language input of a human developer.1. GleanFor arming employees with the tools to get their jobs doneCompanies contain a lot of information that’s crucial for employees to know, but it’s spread out across an array of workplace apps: Slack, Microsoft 365, Google Workspace, Salesforce, and more. Five-year-old Glean offers a user-friendly AI-powered search tool that allows employees to find information and generate answers across more than 100 data sources.In June 2024, the company transformed its existing enterprise AI assistant and search engine into a platform called Work AI platform. It allows employees of all technical backgrounds to quickly generate personalized, accurate answers—and even create their own no-code tools to make the agents work better for the specifics of their jobs and businesses. The Work AI suite also includes a Glean Actions tool, which enables the AI assistant to directly take action on an employee’s behalf within a company’s connected applications. Actions could involve reading data from an application and executing a specific task, creating Jira tickets, publishing new content, or searching for code.In September, Glean doubled down on its user-friendly proposition by making it even easier for non-technical employees to get the most from its tools with next-generation prompting features. These features include a Prompt Builder feature, which allows users to create their own directives for the AI assistant, and a Prompt Library, which includes suggested prompts from Glean, as well ones that a company has shared in its own prompt library.According to a November 2024 report in The Information, Glean was generating around $100 million in annual recurring revenue, more than tripling that metric over the past year. The company closed two funding rounds in 2024: $200 million in February and $260 million in September at a $4.6 billion valuation. Its 200+ customers include Reddit, Instacart, Pinterest, Duolingo, and Databricks.Read more about Glean, honored as No. 6 on Fast Company’s list of the World’s 50 Most Innovative Companies of 2025.2. AnysphereFor giving developers a coding partner with contextual awarenessCursor AI has emerged as a standout in the growing field of AI code editors. The company behind it, Anysphere, made the smart design choice of building the UX based on Microsoft’s Visual Studio Code, a familiar programming environment. Cursor also can access a developer’s or company’s existing code base as a way of fine-tuning code suggestions.Cursor acts like a coding partner that’s aware of the context in which code is being created. It offers code auto-completions, and not just of single lines–it can generate entire sections of code, and then explain the reasoning behind them. Or the developer can explain a new feature or function in plain language and the AI will code a prototype of it.Anysphere says Cursor now has more than 40,000 customers. Developers in online forums say that after using Cursor, they can’t go back to GitHub Copilot. In August, the startup raised a $60 million A round at a $400 million valuation from Andreessen Horowitz, Thrive Capital, OpenAI, Google’s Jeff Dean, OpenAI’s Noam Brown, and the founders of Stripe, GitHub, Ramp, and Perplexity. Four months later it raised a Series B round that closed in January 2025 with $105 million invested, raising its valuation to $2.6 billion.Read more about Anysphere, honored as No. 26 on Fast Company’s list of the World’s 50 Most Innovative Companies of 2025.3. Blackbird.AIFor arming NATO and others with AI that detects AI disinformationBusinesses and other organizations must constantly be aware of how their name is being used in the digital environment, and be able to react quickly if their brand and reputation are distorted by misinformation or disinformation. In 2024 Blackbird.AI released its Compass platform, which lets individual users reality check or get greater context around suspicious claims made in social media posts, videos, links, or memes. The user pastes the content into the Compass tool, which checks it against thousands of trustworthy online sources.In October 2024 Blackbird.AI launched “Compass Vision,” a new AI-based tool for identifying AI deepfake images and videos. Customers can access Compass Vision directly through Blackbird.AI’s platform, or they can use its API to integrate it with their existing threat intelligence and social listening systems. As companies continue to more aggressively protect their market value and brand equity in the digital space, the market for “narrative intelligence” services is likely to grow to as much as $70 billion annually, Blackbird.AI believes. The company has already positioned itself well, and expects its revenues to double or triple over the next year. Blackbird.AI has raised more than $20 million in venture capital so far.4. Google DeepMindFor unfolding the mysteries of structural biochemistryGoogle DeepMind CEO Demis Hassabis and director of research John Jumper won the 2024 Nobel Prize in Chemistry for their parts in discovering and developing the AlphaFold AI models, which can predict the complex structures of virtually all known proteins. Proteins control and drive all chemical reactions within the bodies of organisms, including humans, so the tool is of great interest to researchers in drug development, material science, and environmental science.In 2024 DeepMind expanded its AlphaFold AI system to model how proteins interact with other cell structures, including DNA, RNA, and small molecules that are often used in drugs. The new system, called AlphaFold 3, can model the ways in which proteins “read” our DNA and then carry out the instructions in the body. It lets drug researchers quickly model how new drug compounds might react with certain receptor sites in the body, which could accelerate the exploratory phase of drug development. Traditionally this work has been done experimentally, in a wet lab. Google DeepMind developed AlphaFold 3 in collaboration with London-based Isomorphic Labs, an AI-based drug discovery lab it spun out into an independent unit within Google parent company Alphabet. Isomorphic is now working with Novartis and Eli Lilly. While drugs based on AlphaFold’s breakthroughs are yet to come, it’s already instigated a revolution in structural biochemistry.5. DeepLFor translating everyday business communications into 33 languages, including traditional Chinese and ArabicFast and accurate translation are crucial for multinational corporations, and generative AI has been a natural complement to existing services. One service provider, DeepL, has emerged as a standout for the accuracy and cost-effectiveness of its AI. The company already serves more than 150,000 businesses, governments, and other organizations across the legal, tech, media, manufacturing, and retail industries, including known names such as Nikkei, Panasonic Connect, Zendesk, and Morningstar.In November 2024 the company released DeepL Voice for Meetings, which lets participants speak in their preferred language during meetings and video calls, with real-time captions of others’ comments in their chosen language. DeepL Voice for Conversations does the same thing, but for one-on-one conversations happening on mobile devices. In July 2024, DeepL deployed a new large language model of its own, which its says significantly outperforms LLMs from OpenAI, Google, and Microsoft for translation. DeepL also added Traditional Chinese and Arabic languages to its platform, bringing total supported languages to 33. Beyond translation, DeepL launched a new tool called DeepL Write, designed to help professionals improve their business writing skills.In May 2024 DeepL raised a $300 million funding round and saw its valuation rise to $2 billion–doubling its valuation after its previous funding round a year earlier.6. PerplexityFor turning generative AI into a rival to traditional search, especially for election coveragePerplexity is one of the biggest success stories of the current AI boom. Its “answer engine” has revitalized web search, using a combination of homegrown large language models (LLMs), third-party models (from OpenAI, Anthropic, DeepSeek and others) and web crawlers to return custom answers that are highly relevant and fastidiously cited. The San Francisco-based company saw its user base grow throughout 2024, as it added new features and functions to its platform. Perplexity began experimenting with ads and referrals on its platform late in 2024, and launched “Shop like a Pro”, an AI-powered shopping assistant that lets users research and even purchase products within Perplexity. Users of the Perplexity mobile app users can even snap pictures of items to see related products and buying information.Perplexity’s most surprising creation during 2024 may have been the AI-powered Election Information Hub it launched before the November 2024 U.S. elections. The hub offered voters real-time updates, candidate information, and ballot measure summaries, along with AI-generated analysis based on reliable data from The Associated Press and Democracy Works. Perplexity’s clear, verifiable approach to election coverage gained significant attention during the run-up to the elections.7. Contextual AIFor making the next generation of AI more accurate and efficientTo avoid hallucinations and keep answers on point, AI developers use what’s called retrieval-augmented generation (RAG), where large language models are fed relevant information used to respond to specific queries. Cofounded by CEO Douwe Kiela, who pioneered RAG while at Meta, Contextual AI emerged from stealth mode in June 2023 with a mission to use the power of RAG to build more accurate LLMs for enterprises.In March 2024, the company introduced RAG 2.0, a system that trains LLMs and the RAG ystem together, resulting in Contextual Language Models that are tuned for specific purposes for which they outperform leading commercial and open source models. Contextual also worked with the Allen Institute for Artificial Intelligence to develop OLMoE, an AI system introduced in September that uses an approach called “mixture of experts,” in which a specialized subsection of the model is called on to answer a given question, leaving most of the other model parameters at rest. This can increase a model’s accuracy while making it faster and more energy efficient.Contextual, which counts HSBC, Qualcomm and The Economist as customers, announced in August 2024 that it raised an $80 million Series A round to fund further development of its enterprise-grade AI systems.8. HarveyFor giving lawyers a trustworthy AI agentUsing large language models in legal work has long been a tantalizing possibility. But fears over inaccuracies due to AI hallucinations have caused the legal field to move slowly in their adoption of them. Harvey has managed some real innovations aimed at making its AI legal assistant more reliable and transparent about its work. The Harvey Assistant can read and analyze cases and other data faster than a human lawyer or legal assistant, and can draft documents, analyze information, and answer questions about hundreds of complex legal files.Harvey gave the Assistant some important upgrades in August 2024. It added a series of specialized modes tailored to different kinds of legal work, it trained its AI to refine and expand on its initial responses, and it improved the system’s outputs and processing speed. Harvey says the new version of Assistant reduces AI hallucinations by 60% and improves the accuracy of cited sources by 23%. In a move to demystify the way the assistant comes up with its answers, Harvey released a report called “BigLaw Bench” describing its model training and evaluation methodologies.The company more than tripled its employees during 2024, and added more than 100 new customers in 15 countries. With a new $100 million funding round in July 2024, the company saw its valuation rise to $1.5 billion.9. Khan AcademyFor empowering students and their teachers with a free AI writing coachIn 2023, Khan Academy launched Khanmigo, an experimental AI tutor designed to give students one-on-one help in tasks such as practicing math problems, brainstorming project ideas, and analyzing literature. Since then, thousands of students and teachers have started using the tool, and Khan Academy has been busy adding new tools and features to the platform.During 2024, the non-profit built some important new functionality into its Khanamigo Writing Coach, which had originally been designed to act as a writing tutor for students. The tool now helps teachers, too, giving them access to detailed reports on student progress. It generates high-level insights on the writing challenges of individual students, and even helps teachers identify difficulties that multiple students in the class are facing. All this addresses a real challenge in English education–the time constraints teachers face when providing feedback on writing.Khan Academy cites a real-life example of a teacher with 100 students who typically needed 17 hours to review the first drafts of a two-page essay assignment, assuming the teacher spent 10 minutes on each paper. In an era when AI offers to do our writing for us, Khanamigo Writing Coach is instead focused on helping students break through barriers to effective written communication—and on helping teachers guide them along the way.10. SpeakFor supercharging English-language learning with live conversational roleplaysSpeak’s AI English tutor app, which is widely used in Korea and Japan, has been around for years. But the company took a big step forward during 2024 with a little help from OpenAI. The app already offered an English tutor that could teach and converse, but the conversations felt slow and unnatural. That’s because Speak’s system had to transcribe the user’s speech, run it through a text-based LLM workflow, then synthesize the AI character’s speech. Each of these steps created gaps and errors in the back-and-forth, which was disruptive to the learning process.Then Speak became one of the first companies to get access to OpenAI’s Realtime API, using it to power its “Live Roleplays” feature. The Realtime API is unique in that it’s powered by AI that treats both text and voice in the same way–as common tokens within a multi-modal model. So no conversions are necessary, making the model’s response time super-fast.As a result, Speak’s tutor can generate its voice responses with almost no delay. This makes exchanges between student and AI tutor feel much more fluid and natural. And that’s very important, because the best and fastest way to learn another language is through real life conversations. Speak may not be exactly real-life, but with OpenAI’s help it’s a lot closer to real-time.11. PikaFor making a state-of-the-art video generator that’s accessible to nonprofessionalsPika’s founders, Demi Guo and Chenlin Meng, dropped out of Stanford’s artificial intelligence PhD program in 2023 to pursue a big idea. The world needed a world-class video generation app that was designed for regular people–not just professional creators, film-makers and AI early adopters.The duo and their new company got the attention of the AI industry with the release of the second version of their model, Pika 1.5, and the accompanying app, in September 2024. People soon began pumping out videos using the app’s motion control and effects such as Pikaffects, with which users can melt, inflate, crush, squish or explode pretty much anything. This unleashed a wave of videos that were perfect for social media sites like TikTok.In December 2024, the company dropped its Pika 2.0 model, which introduced the ability to dress up videos with people, objects, and places from photos they upload to the app. Just a month later, it launched its 2.1 model, which added an Advanced Motion Control feature, which made animation or high-motion video more fluid and natural-looking.Pika is still a very young company, but it’s already taken a place in the top tier of AI video generators, along with OpenAI’s Sora, Runway’s Gen-3 Alpha, and Google’s Veo.12. CanvaFor bringing Gen AI design to the largest organizationsCanva has the most popular app in the design and creative category, with more than 100 million downloads in the Google Play store alone. The company has been busily adding AI features to its app, and many of its users are embracing them. In 2024, Canva continued expanding its Magic Studio suite of AI tools. The suite, which is aimed at designers within organizations big and small, now includes 12 native AI products built on proprietary models from Canva and its partners, including OpenAI, Google and Runway. They include a “text to graphic” generation tool, AI photo editing, and a feature that assembles a highlight reel of the best clips from a longer video.Canva also strengthened its AI hand in 2024 by acquiring Leonardo.Ai, a generative AI platform specializing in image and video that’s used by 19 million creatives globally. Canva was quick to begin powering its own new features using Leonardo’s powerful Phoenix foundation model, starting with the new Dream Lab image generator it launched in October. Canva did meet with some backlash when it raised the prices of its Teams plans because of the new AI features. Still, Canva it says its growth has continued to accelerate, reaching 220 million monthly active users by year-end, the last 20 million of those added in the fourth quarter alone.13. SalesforceFor letting customers design no-code AI agents that can handle customer service, marketing, and moreSalesforce moved rapidly to embrace AI agents during 2024, pivoting from its former “Einstein” AI platform to Agentforce, a new platform that lets Salesforce customers design their own no-code agents to handle customer service, sales, marketing, scheduling and other tasks. Agents go beyond chatbots by being able to perform work-related tasks without the constant supervision of humans. They can, for example, analyze data, make decisions, and work through tasks step by step on the user’s behalf.For example, Salesforce offers an agent called Sales Development Representative (SDR) that can engage with sales prospects at any time of the day, answer questions, schedule sales meetings, and even manage objections. In the second half of 2024 Salesforce released two major versions of the Agentforce platform. The vision is big—agents could be as significant a shift for business software as the move to the cloud 25 years ago—and while it’s still early, the first adopters of the technology include some big names, such as Disney, OpenTable, Saks Fifth Avenue, and Wiley.On an early December earnings call, Salesforce CEO Marc Benioff said his company is “unleashing this new era of digital labor for every business and industry.” He added that even though the Agentforce platform had only been available since late October, his company had already “signed 200 deals” to give companies access.14. OsmoFor teaching AI how to smellThe startup Osmo, which was spun out of Google Research in 2022, has developed a way of giving AI the sense of smell. The company–which is backed by Google Ventures, Lux Capital, and the Bill & Melinda Gates Foundation–developed an AI system that can identify and recreate odors. It uses a number of sensitive sensors to detect molecules in the air that create odors, then feeds the sensor data to its AI models, which can represent the molecules digitally, as tokens within a neural network. The system can also create totally new scents, such as might be used in perfumes.Beyond the obvious application in the fragrance industry, Osmo has already tested its system for the detection of counterfeit goods, which usually have a very different olfactory signature than legit products. From July through September of 2024, Osmo deployed its system of sensors and models for four weeks at a fulfillment center for an online marketplace, where it gave hundreds of boxes of shoes the smell test. In the end Osmo proved there to be a measurable smell difference between authentic and counterfeit shoes, and that its system can ID the fakes quickly and accurately. It’s likely that many meaningful applications for Osmo’s AI haven’t yet been realized, such as in security work, disease detection or–you guessed it–Smell-o-vision.15. EvolutionaryScaleFor applying AI to design new proteins that the world needsEvolutionaryScale is an AI company that develops advanced artificial intelligence models for biological research, particularly focusing on proteins. The company’s main product is ESM3, an generative AI model for biology that can reason over the sequence, structure, and function of proteins. ESM3 can be used to generate new protein designs that would take millions of years to evolve in nature, and that can be realized through synthetic biology methods, the company says. Such proteins could be useful in environmental science and materials science. In 2024 ESM3 generated a new Green Fluorescent Protein (GFP), a type of protein responsible for the glowing effect seen in jellyfish and the vibrant fluorescent colors of coral. As a result of its unique properties, GFP has become an important tool in molecular biology, helping scientists to see molecules inside cells. EvolutionaryScale also published a paper in Nature that detailed how a team of scientists utilized a variant model called ESMFold to unveil deep and distant evolutionary relationships within the flavivirus family, which includes viruses such as hepatitis C, dengue, and Zika. In 2024 the company raised a $142 million round from noted AI investors Nat Friedman and Daniel Gross, along with Lux Capital, Amazon, and Nvidiz’s venture capital arm, and others.Explore the full 2025 list of Fast Company’s Most Innovative Companies, 609 organizations that are reshaping industries and culture. We’ve selected the companies making the biggest impact across 58 categories, including advertising, applied AI, biotech, retail, sustainability, and more.

It’s been gradual, but generative AI models and the apps they power have begun to measurably deliver returns for businesses. Organizations across many industries believe their employees are more productive and efficient with AI tools such as chatbots and coding assistants at their side. 

Numerous AI startups found traction offering such solutions during 2024. Glean, for example, puts cutting-edge AI search capabilities in the hands of employees so that they can tap into various apps and platforms to find documents and corporate intelligence. Contextual AI lets organizations put a company’s proprietary intelligence into a secure data store, then lets them build AI apps that can call on that data. Enterprises are also using AI apps to protect softer corporate assets, such as reputation. Blackbird.AI offers a web app that enterprises use to monitor how their brand name is portrayed in social media posts, videos, links, and memes. 

Other standout AI apps focuse on specific industries. Google DeepMind put drug discovery ahead by years when it improved on its AlphaFold model, which now can model and predict the behaviors of proteins and other actors within the cell. Harvey has found its legs within the legal industry by offering an AI legal assistant that can write briefs, summarize and compare cases, and more. 

Coding assistants grew considerably–both in capability and usage–during 2024. Anysphere’s Cursor tool, for example, helped advance the genre from simply completing lines or sections of code to building whole software functions based on the plain language input of a human developer.

1. Glean

For arming employees with the tools to get their jobs done

Companies contain a lot of information that’s crucial for employees to know, but it’s spread out across an array of workplace apps: Slack, Microsoft 365, Google Workspace, Salesforce, and more. Five-year-old Glean offers a user-friendly AI-powered search tool that allows employees to find information and generate answers across more than 100 data sources.

In June 2024, the company transformed its existing enterprise AI assistant and search engine into a platform called Work AI platform. It allows employees of all technical backgrounds to quickly generate personalized, accurate answers—and even create their own no-code tools to make the agents work better for the specifics of their jobs and businesses. The Work AI suite also includes a Glean Actions tool, which enables the AI assistant to directly take action on an employee’s behalf within a company’s connected applications. Actions could involve reading data from an application and executing a specific task, creating Jira tickets, publishing new content, or searching for code.

In September, Glean doubled down on its user-friendly proposition by making it even easier for non-technical employees to get the most from its tools with next-generation prompting features. These features include a Prompt Builder feature, which allows users to create their own directives for the AI assistant, and a Prompt Library, which includes suggested prompts from Glean, as well ones that a company has shared in its own prompt library.

According to a November 2024 report in The Information, Glean was generating around $100 million in annual recurring revenue, more than tripling that metric over the past year. The company closed two funding rounds in 2024: $200 million in February and $260 million in September at a $4.6 billion valuation. Its 200+ customers include Reddit, Instacart, Pinterest, Duolingo, and Databricks.

Read more about Glean, honored as No. 6 on Fast Company’s list of the World’s 50 Most Innovative Companies of 2025.

2. Anysphere

For giving developers a coding partner with contextual awareness

Cursor AI has emerged as a standout in the growing field of AI code editors. The company behind it, Anysphere, made the smart design choice of building the UX based on Microsoft’s Visual Studio Code, a familiar programming environment. Cursor also can access a developer’s or company’s existing code base as a way of fine-tuning code suggestions.

Cursor acts like a coding partner that’s aware of the context in which code is being created. It offers code auto-completions, and not just of single lines–it can generate entire sections of code, and then explain the reasoning behind them. Or the developer can explain a new feature or function in plain language and the AI will code a prototype of it.

Anysphere says Cursor now has more than 40,000 customers. Developers in online forums say that after using Cursor, they can’t go back to GitHub Copilot. In August, the startup raised a $60 million A round at a $400 million valuation from Andreessen Horowitz, Thrive Capital, OpenAI, Google’s Jeff Dean, OpenAI’s Noam Brown, and the founders of Stripe, GitHub, Ramp, and Perplexity. Four months later it raised a Series B round that closed in January 2025 with $105 million invested, raising its valuation to $2.6 billion.

Read more about Anysphere, honored as No. 26 on Fast Company’s list of the World’s 50 Most Innovative Companies of 2025.

3. Blackbird.AI

For arming NATO and others with AI that detects AI disinformation

Businesses and other organizations must constantly be aware of how their name is being used in the digital environment, and be able to react quickly if their brand and reputation are distorted by misinformation or disinformation. In 2024 Blackbird.AI released its Compass platform, which lets individual users reality check or get greater context around suspicious claims made in social media posts, videos, links, or memes. The user pastes the content into the Compass tool, which checks it against thousands of trustworthy online sources.

In October 2024 Blackbird.AI launched “Compass Vision,” a new AI-based tool for identifying AI deepfake images and videos. Customers can access Compass Vision directly through Blackbird.AI’s platform, or they can use its API to integrate it with their existing threat intelligence and social listening systems.

As companies continue to more aggressively protect their market value and brand equity in the digital space, the market for “narrative intelligence” services is likely to grow to as much as $70 billion annually, Blackbird.AI believes. The company has already positioned itself well, and expects its revenues to double or triple over the next year. Blackbird.AI has raised more than $20 million in venture capital so far.

4. Google DeepMind

For unfolding the mysteries of structural biochemistry

Google DeepMind CEO Demis Hassabis and director of research John Jumper won the 2024 Nobel Prize in Chemistry for their parts in discovering and developing the AlphaFold AI models, which can predict the complex structures of virtually all known proteins. Proteins control and drive all chemical reactions within the bodies of organisms, including humans, so the tool is of great interest to researchers in drug development, material science, and environmental science.

In 2024 DeepMind expanded its AlphaFold AI system to model how proteins interact with other cell structures, including DNA, RNA, and small molecules that are often used in drugs. The new system, called AlphaFold 3, can model the ways in which proteins “read” our DNA and then carry out the instructions in the body. It lets drug researchers quickly model how new drug compounds might react with certain receptor sites in the body, which could accelerate the exploratory phase of drug development. Traditionally this work has been done experimentally, in a wet lab.

Google DeepMind developed AlphaFold 3 in collaboration with London-based Isomorphic Labs, an AI-based drug discovery lab it spun out into an independent unit within Google parent company Alphabet. Isomorphic is now working with Novartis and Eli Lilly. While drugs based on AlphaFold’s breakthroughs are yet to come, it’s already instigated a revolution in structural biochemistry.

5. DeepL

For translating everyday business communications into 33 languages, including traditional Chinese and Arabic

Fast and accurate translation are crucial for multinational corporations, and generative AI has been a natural complement to existing services. One service provider, DeepL, has emerged as a standout for the accuracy and cost-effectiveness of its AI. The company already serves more than 150,000 businesses, governments, and other organizations across the legal, tech, media, manufacturing, and retail industries, including known names such as Nikkei, Panasonic Connect, Zendesk, and Morningstar.

In November 2024 the company released DeepL Voice for Meetings, which lets participants speak in their preferred language during meetings and video calls, with real-time captions of others’ comments in their chosen language. DeepL Voice for Conversations does the same thing, but for one-on-one conversations happening on mobile devices. In July 2024, DeepL deployed a new large language model of its own, which its says significantly outperforms LLMs from OpenAI, Google, and Microsoft for translation. DeepL also added Traditional Chinese and Arabic languages to its platform, bringing total supported languages to 33. Beyond translation, DeepL launched a new tool called DeepL Write, designed to help professionals improve their business writing skills.

In May 2024 DeepL raised a $300 million funding round and saw its valuation rise to $2 billion–doubling its valuation after its previous funding round a year earlier.

6. Perplexity

For turning generative AI into a rival to traditional search, especially for election coverage

Perplexity is one of the biggest success stories of the current AI boom. Its “answer engine” has revitalized web search, using a combination of homegrown large language models (LLMs), third-party models (from OpenAI, Anthropic, DeepSeek and others) and web crawlers to return custom answers that are highly relevant and fastidiously cited. 

The San Francisco-based company saw its user base grow throughout 2024, as it added new features and functions to its platform. Perplexity began experimenting with ads and referrals on its platform late in 2024, and launched “Shop like a Pro”, an AI-powered shopping assistant that lets users research and even purchase products within Perplexity. Users of the Perplexity mobile app users can even snap pictures of items to see related products and buying information.

Perplexity’s most surprising creation during 2024 may have been the AI-powered Election Information Hub it launched before the November 2024 U.S. elections. The hub offered voters real-time updates, candidate information, and ballot measure summaries, along with AI-generated analysis based on reliable data from The Associated Press and Democracy Works. Perplexity’s clear, verifiable approach to election coverage gained significant attention during the run-up to the elections.

7. Contextual AI

For making the next generation of AI more accurate and efficient

To avoid hallucinations and keep answers on point, AI developers use what’s called retrieval-augmented generation (RAG), where large language models are fed relevant information used to respond to specific queries. Cofounded by CEO Douwe Kiela, who pioneered RAG while at Meta, Contextual AI emerged from stealth mode in June 2023 with a mission to use the power of RAG to build more accurate LLMs for enterprises.

In March 2024, the company introduced RAG 2.0, a system that trains LLMs and the RAG ystem together, resulting in Contextual Language Models that are tuned for specific purposes for which they outperform leading commercial and open source models. Contextual also worked with the Allen Institute for Artificial Intelligence to develop OLMoE, an AI system introduced in September that uses an approach called “mixture of experts,” in which a specialized subsection of the model is called on to answer a given question, leaving most of the other model parameters at rest. This can increase a model’s accuracy while making it faster and more energy efficient.

Contextual, which counts HSBC, Qualcomm and The Economist as customers, announced in August 2024 that it raised an $80 million Series A round to fund further development of its enterprise-grade AI systems.

8. Harvey

For giving lawyers a trustworthy AI agent

Using large language models in legal work has long been a tantalizing possibility. But fears over inaccuracies due to AI hallucinations have caused the legal field to move slowly in their adoption of them. Harvey has managed some real innovations aimed at making its AI legal assistant more reliable and transparent about its work. The Harvey Assistant can read and analyze cases and other data faster than a human lawyer or legal assistant, and can draft documents, analyze information, and answer questions about hundreds of complex legal files.

Harvey gave the Assistant some important upgrades in August 2024. It added a series of specialized modes tailored to different kinds of legal work, it trained its AI to refine and expand on its initial responses, and it improved the system’s outputs and processing speed. Harvey says the new version of Assistant reduces AI hallucinations by 60% and improves the accuracy of cited sources by 23%. In a move to demystify the way the assistant comes up with its answers, Harvey released a report called “BigLaw Bench” describing its model training and evaluation methodologies.

The company more than tripled its employees during 2024, and added more than 100 new customers in 15 countries. With a new $100 million funding round in July 2024, the company saw its valuation rise to $1.5 billion.

9. Khan Academy

For empowering students and their teachers with a free AI writing coach

In 2023, Khan Academy launched Khanmigo, an experimental AI tutor designed to give students one-on-one help in tasks such as practicing math problems, brainstorming project ideas, and analyzing literature. Since then, thousands of students and teachers have started using the tool, and Khan Academy has been busy adding new tools and features to the platform.

During 2024, the non-profit built some important new functionality into its Khanamigo Writing Coach, which had originally been designed to act as a writing tutor for students. The tool now helps teachers, too, giving them access to detailed reports on student progress. It generates high-level insights on the writing challenges of individual students, and even helps teachers identify difficulties that multiple students in the class are facing. All this addresses a real challenge in English education–the time constraints teachers face when providing feedback on writing.

Khan Academy cites a real-life example of a teacher with 100 students who typically needed 17 hours to review the first drafts of a two-page essay assignment, assuming the teacher spent 10 minutes on each paper. In an era when AI offers to do our writing for us, Khanamigo Writing Coach is instead focused on helping students break through barriers to effective written communication—and on helping teachers guide them along the way.

10. Speak

For supercharging English-language learning with live conversational roleplays

Speak’s AI English tutor app, which is widely used in Korea and Japan, has been around for years. But the company took a big step forward during 2024 with a little help from OpenAI. The app already offered an English tutor that could teach and converse, but the conversations felt slow and unnatural. That’s because Speak’s system had to transcribe the user’s speech, run it through a text-based LLM workflow, then synthesize the AI character’s speech. Each of these steps created gaps and errors in the back-and-forth, which was disruptive to the learning process.

Then Speak became one of the first companies to get access to OpenAI’s Realtime API, using it to power its “Live Roleplays” feature. The Realtime API is unique in that it’s powered by AI that treats both text and voice in the same way–as common tokens within a multi-modal model. So no conversions are necessary, making the model’s response time super-fast.

As a result, Speak’s tutor can generate its voice responses with almost no delay. This makes exchanges between student and AI tutor feel much more fluid and natural. And that’s very important, because the best and fastest way to learn another language is through real life conversations. Speak may not be exactly real-life, but with OpenAI’s help it’s a lot closer to real-time.

11. Pika

For making a state-of-the-art video generator that’s accessible to nonprofessionals

Pika’s founders, Demi Guo and Chenlin Meng, dropped out of Stanford’s artificial intelligence PhD program in 2023 to pursue a big idea. The world needed a world-class video generation app that was designed for regular people–not just professional creators, film-makers and AI early adopters.

The duo and their new company got the attention of the AI industry with the release of the second version of their model, Pika 1.5, and the accompanying app, in September 2024. People soon began pumping out videos using the app’s motion control and effects such as Pikaffects, with which users can melt, inflate, crush, squish or explode pretty much anything. This unleashed a wave of videos that were perfect for social media sites like TikTok.

In December 2024, the company dropped its Pika 2.0 model, which introduced the ability to dress up videos with people, objects, and places from photos they upload to the app. Just a month later, it launched its 2.1 model, which added an Advanced Motion Control feature, which made animation or high-motion video more fluid and natural-looking.

Pika is still a very young company, but it’s already taken a place in the top tier of AI video generators, along with OpenAI’s Sora, Runway’s Gen-3 Alpha, and Google’s Veo.

12. Canva

For bringing Gen AI design to the largest organizations

Canva has the most popular app in the design and creative category, with more than 100 million downloads in the Google Play store alone. The company has been busily adding AI features to its app, and many of its users are embracing them.

In 2024, Canva continued expanding its Magic Studio suite of AI tools. The suite, which is aimed at designers within organizations big and small, now includes 12 native AI products built on proprietary models from Canva and its partners, including OpenAI, Google and Runway. They include a “text to graphic” generation tool, AI photo editing, and a feature that assembles a highlight reel of the best clips from a longer video.

Canva also strengthened its AI hand in 2024 by acquiring Leonardo.Ai, a generative AI platform specializing in image and video that’s used by 19 million creatives globally. Canva was quick to begin powering its own new features using Leonardo’s powerful Phoenix foundation model, starting with the new Dream Lab image generator it launched in October.

Canva did meet with some backlash when it raised the prices of its Teams plans because of the new AI features. Still, Canva it says its growth has continued to accelerate, reaching 220 million monthly active users by year-end, the last 20 million of those added in the fourth quarter alone.

13. Salesforce

For letting customers design no-code AI agents that can handle customer service, marketing, and more

Salesforce moved rapidly to embrace AI agents during 2024, pivoting from its former “Einstein” AI platform to Agentforce, a new platform that lets Salesforce customers design their own no-code agents to handle customer service, sales, marketing, scheduling and other tasks. Agents go beyond chatbots by being able to perform work-related tasks without the constant supervision of humans. They can, for example, analyze data, make decisions, and work through tasks step by step on the user’s behalf.

For example, Salesforce offers an agent called Sales Development Representative (SDR) that can engage with sales prospects at any time of the day, answer questions, schedule sales meetings, and even manage objections. In the second half of 2024 Salesforce released two major versions of the Agentforce platform. The vision is big—agents could be as significant a shift for business software as the move to the cloud 25 years ago—and while it’s still early, the first adopters of the technology include some big names, such as Disney, OpenTable, Saks Fifth Avenue, and Wiley.

On an early December earnings call, Salesforce CEO Marc Benioff said his company is “unleashing this new era of digital labor for every business and industry.” He added that even though the Agentforce platform had only been available since late October, his company had already “signed 200 deals” to give companies access.

14. Osmo

For teaching AI how to smell

The startup Osmo, which was spun out of Google Research in 2022, has developed a way of giving AI the sense of smell. The company–which is backed by Google Ventures, Lux Capital, and the Bill & Melinda Gates Foundation–developed an AI system that can identify and recreate odors. It uses a number of sensitive sensors to detect molecules in the air that create odors, then feeds the sensor data to its AI models, which can represent the molecules digitally, as tokens within a neural network. The system can also create totally new scents, such as might be used in perfumes.

Beyond the obvious application in the fragrance industry, Osmo has already tested its system for the detection of counterfeit goods, which usually have a very different olfactory signature than legit products. From July through September of 2024, Osmo deployed its system of sensors and models for four weeks at a fulfillment center for an online marketplace, where it gave hundreds of boxes of shoes the smell test. In the end Osmo proved there to be a measurable smell difference between authentic and counterfeit shoes, and that its system can ID the fakes quickly and accurately.

It’s likely that many meaningful applications for Osmo’s AI haven’t yet been realized, such as in security work, disease detection or–you guessed it–Smell-o-vision.

15. EvolutionaryScale

For applying AI to design new proteins that the world needs

EvolutionaryScale is an AI company that develops advanced artificial intelligence models for biological research, particularly focusing on proteins. The company’s main product is ESM3, an generative AI model for biology that can reason over the sequence, structure, and function of proteins. ESM3 can be used to generate new protein designs that would take millions of years to evolve in nature, and that can be realized through synthetic biology methods, the company says. Such proteins could be useful in environmental science and materials science. In 2024 ESM3 generated a new Green Fluorescent Protein (GFP), a type of protein responsible for the glowing effect seen in jellyfish and the vibrant fluorescent colors of coral. As a result of its unique properties, GFP has become an important tool in molecular biology, helping scientists to see molecules inside cells. EvolutionaryScale also published a paper in Nature that detailed how a team of scientists utilized a variant model called ESMFold to unveil deep and distant evolutionary relationships within the flavivirus family, which includes viruses such as hepatitis C, dengue, and Zika. In 2024 the company raised a $142 million round from noted AI investors Nat Friedman and Daniel Gross, along with Lux Capital, Amazon, and Nvidiz’s venture capital arm, and others.

Explore the full 2025 list of Fast Company’s Most Innovative Companies, 609 organizations that are reshaping industries and culture. We’ve selected the companies making the biggest impact across 58 categories, including advertisingapplied AIbiotechretailsustainability, and more.

Read the full story here.
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When Susan Wojcicki Discovered She Had Lung Cancer, She Decided to Find Out Why

After her shocking lung cancer diagnosis, the late Susan Wojcicki dedicated herself to fighting the disease and looking for answers

In 2022 Susan Wojcicki was on top of the world—CEO of YouTube, parent to five kids and running a few miles a day—when she received a shocking diagnosis: metastatic lung cancer. She soon resigned from YouTube and dedicated herself to fighting the disease and looking for answers. Why does the leading cause of cancer deaths receive less funding than some less lethal cancers? How could her lung cancer have progressed so far undetected? And how did she get lung cancer even though she had never smoked? This episode is dedicated to Wojcick, who passed away last year.LISTEN TO THE PODCASTOn supporting science journalismIf you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.TRANSCRIPTElah Feder: One day in late 2022, Susan Wojcicki had plans to meet up with her childhood friend, Joanna Strober. Here's Joanna.Joanna Strober: We were supposed to go for a walk on a Sunday, and she called me and she canceled because she had some hip pain. And you know, I just thought, okay, you probably exercised too much. Susan was a runner. Maybe she pulled something, but she went to her doctor and then she- I guess she got an MRI. And it was cancer, and that was her first indication—hip pain.Elah Feder: Lung cancer, and it had spread, which was shocking. Susan, she was 54 years old and in top shape, running a few miles a day at that point. And on top of everything, Susan had never smoked.Joanna Strober: Susan led the most healthy life. She didn't eat sugar. She was very careful about exercising every day. She was very careful about not eating pesticides. I mean, she was on the extreme of leading a healthy lifestyle. So yes, it's not just the not smoking, but she was doing everything she possibly could to stay healthy.Elah Feder: Susan's experience is not as unusual as you'd think. Lung cancer is the most common kind of cancer in the world. Third most common in the US. Smoking is still the leading cause, but a growing number of people who get lung cancer don't smoke, were never smokers. That's especially true of women who get lung cancer.To be clear, this is a terrible diagnosis to get for anyone, whether they smoked or not, but for those who haven't, there can be an extra layer on top of all the other feelings: confusion. So when Susan got this diagnosis, of course she wanted treatments, but she also wanted answers. Why did this happen to her?Elah Feder: This is Lost Women of Science, and I'm Elah FederKatie Hafner: And I'm Katie Hafner and today the story of Susan Wojcicki, who died last year of lung cancer.Elah, before we get to Susan's lung cancer, I want to acknowledge—some people out there might already be familiar with her name because Susan Wojcicki was one of the most successful and influential people in the world.Elah Feder: Yeah. Susan was the longtime CEO of YouTube, and she got involved in Google very early on, so that by 2022, her estimated net worth was about $800 million.Um, there's a story that gets quoted a lot about her early business acumen. When she was a kid, she and her friend, Joanna Strober—who you heard earlier—they sold what they called spice ropes. Here's Joanna again.Joanna Strober: It's really not that big of a deal. All we did was we made these yellow and orange yarn things and we put cinnamon in them and we called them spice ropes, and we sold them to the neighbors who of course had to buy them because they were neighbors.Elah Feder: The way the story gets told, it's like, look at this Susan kid born entrepreneur, but Joanna says, “no, no, no.” The point is they were just regular kids being kids.Katie Hafner: Right. It was their version of a lemonade stand. Right?Elah Feder: Exactly.Joanna Strober: We were not special. We were normal 10 year olds in a really beautiful environment that was supportive of our endeavors.The environment was the Stanford community. We grew up surrounded by smart people who were doing really interesting research and who, quite honestly, were changing the world in lots of ways. Lots of scientists, physicists, entrepreneurs. It was a wonderful way to grow up because everything felt very possible growing up on the Stanford campus in the seventies.Elah Feder: Susan grew up on the Stanford campus because her dad was a physics professor there, Stanley Wojcicki. Um, her mom—also very impressive—Esther Wojcicki, she's a journalist, educator, writer. She- she wrote a book called How to Raise Successful People, and I mean Esther Wojcicki has the cred to back this up. Uh, a couple of years ago, Mattel decided to honor women in STEM by making Barbies of some of the more notable figures. All three of her kids made the cut.Katie Hafner: Of course they did. Esther: mother of champions.Elah Feder: What you're hearing is a video of Susan, Janet and Anne Wojcicki all unboxing their Barbie likenesses.Janet Wojcicki: Let's do physics, mathematics. Let's show them what the childhood was really like!Elah Feder: You just heard Janet, she's the middle sister. Uh, she's a professor of pediatrics and epidemiology at UCSF.Then there's the youngest kid. Anne.Katie Hafner: Yes, Anne Wojcicki: the co-founder of 23andMe. Listeners might recognize her name from all the times we thank the Anne Wojcicki Foundation in the credits—and her foundation funded this episode as well, right?Elah Feder: And then there was Susan, the eldest. I talked to Anne and Janet a few weeks ago. All all three sisters were very close in age, all born in a span of, of just five years. But talking to them, it sounds like Susan had classic first child syndrome. You're gonna hear Anne first.Anne Wojcicki: She was always the responsible one. Janet was not. And- and but-Janet Wojckick: And you were halfway in between.Anne Wojcicki: I was halfway in between, yeah. My friends always liked hanging out with Susan, but they didn't like hanging out with Janet. And then part is that Susan was so kind. Susan was kind. She was responsible, like she would take us out to ice cream. She would pick me up from ice skating. She was like, always on time.Elah Feder: If Susan Wojcicki promised you ice cream, you were gonna get ice cream. This is a quality that surely you'd want in a leader. But Anne says Susan wasn't born to be a mogul or anything.Anne Wojcicki: I'd say Susan was very much almost like the accidental CEO. I never would've looked at her when we were younger and said like, “oh, my sister is going to be a CEO.” You know, like there's definitely other people I look at in high school who have focused on finance and thinking about their careers and stuff.Elah Feder: Susan, on the other hand, was a history and literature major, but in 1998 she got involved in the creation of a new tech company when she rented out her garage to two Guys: Larry Page and Sergey Brin. They were starting a new company, and I think you know the name. Um…Katie Hafner: Google, if I'm not mistaken!Elah Feder: Google!Newscaster: a little engine that could, we're talking about this morning, has nothing to do with the children's story about a brave little locomotive. That's because this engine is a search engine. Google by name, an internet website, partnered with our own CBS news.com.Elah Feder: Susan soon became the company's first marketing manager, and a few years after that she led them in buying another tech company: a company called YouTube. And in 2014 she was appointed YouTube CEO.Newscaster 2: Well, her name is Susan Wojcicki and she's one of the most powerful women in tech. She's also mother of four and more than eight months pregnant with her fifth child. So how did she do it all?Elah Feder: So, in 2022, Susan has been CEO of YouTube for eight years. Somehow she still had time to raise five children and run a few miles a day, which is completely alien to me.You know that Beyonce meme, like Beyonce has as many hours in the day as you do, and it's, like, meant to shame you for being inadequate. Um, that is how I feel hearing about Susan Wojcicki. Point is she's doing really well when she gets this news. And it's a complete shock. Here's Anne again.Anne Wojcicki: I think when you suddenly- like Susan was kind of on top of the world, like she loved her job, YouTube is taking off and she had her five kids and they're all amazing and um, and then suddenly it was like, your life is gonna be over soon. Right away the first priority was treatment.Elah Feder: Very quickly, Susan resigned from YouTube and really gave herself over to fighting this.Joanna Strober: What she really did was started working with scientists…Elah Feder: Joanna, again.Joanna Strober: …doing the in-depth work to understand the science and what treatments were available and what she could do, but it was very scientifically focused.Elah Feder: Susan would go on to learn a lot about lung cancer, and one of the things that she learned that really disturbed her is that doctors were not great at detecting her kind of cancer: lung cancer in non-smokers. Often there are no early signs, or in Susan's case, very few signs even when the cancer has progressed. Here's her sister, Janet.Janet Wojcicki: We went to see her, you know, thoracic oncologist, right? Her lung oncologist. She's sitting on the table and the oncologist is actually examining her and she's listening to her lungs and Susan's basically saying like, you don't hear anything, right? You, you hear nothing like it sounds totally normal, right? And the oncologist is like, yeah. So just from a clinical exam, she was perfect. There was nothing. So she was like, how is it that I have stage four lung cancer? You're an oncologist, you're listening to me, you're looking at me, and like, nothing's awry. So it's- it was that kind of disconnect that was also kind of a call to action.Elah Feder: How could Susan's lung cancer have gone undetected so long that it had spread? And why is it that when lung cancer is detected, survival rates aren't higher? Well, part of the reason might be that we need more funding despite some very effective anti-smoking campaigns, lung cancer is still the leading cause of cancer deaths in the U.S., but it only gets about half the federal research funds that breast cancer does- or it did. The NIH has been slashing research funding, including cancer research. We'll see how this all shakes out in the coming months and years. In any case, lung cancer might not be the only cancer that's in trouble going forward. But historically, part of the reason that lung cancer got proportionately less funding might have to do with attitudes toward lung cancer. It just isn't viewed the same way that breast or prostate or pancreatic cancers are. It's often seen as something you bring on yourself. Here's Anne again.Anne Wojcicki: I think that the stigma has really hurt research- is that people look at it and they say like, oh, well you smoked. And um, and I think that's one of the things that Susan really wanted to change.Elah Feder: It took a long time to get this broad consensus that smoking causes lung cancer. If we go back to the forties and fifties, that's when you first see a bunch of studies coming out that demonstrate this link. And even so, if you asked a doctor in 1960, if the link had been proven, a fifth said they didn't think so. About half of them still smoked, but eventually the other side prevailed. We now have a consensus that smoking does cause lung cancer, but the downside is stigma.Katie Hafner: You know? And the stigma is really, really deeply embedded in our society. The minute you hear that somebody has been diagnosed with lung cancer, the very first thing you ask is, do they smoke? Have they smoked? Have you smoked? Has she smoked? And, so you immediately assign that stigma to the lung cancer even when it quickly gets established that there was no smoking. And that could also have an indirect effect on this lack of funding.Elah Feder: Yeah, that's the suspicion, and of course the stigma and the victim blaming is terrible for people who did smoke too. So, that really bothered Susan and she gave a lot of money for research, but she was also at the same time just investigating her own cancer. You know how, how did she get it?Anne Wojcicki: I think one of the first things we did was we got the houses tested for radon exposure.Elah Feder: Katie, do you know about radon? Are you familiar with radon?Katie Hafner: I mean, I'm familiar, but I have no idea what that has to do with it. Tell me.Elah Feder: I only recently learned about this, so, so radon is a radioactive gas. It- it sounds like one of these scary things you read on the internet, but this is real. It's a radioactive gas that naturally occurs in the ground, but it leaks into basements where it can accumulate to dangerous levels. It has no smell, no- no color. So you really would not know if it's in your home unless you test for it. Um, but it's the leading cause of lung cancer in non-smokers.Katie Hafner: You mean before secondhand smoke?Elah Feder: Apparently. In the U.S. radon is the number one cause of lung cancer among non-smokers according to the EPA.Other causes, of course, do include air pollution, asbestos exposure, and secondhand smoke.Katie Hafner: Wow. So, I've always thought secondhand smoke was it? But it sounds like it was, it sounds like it's radon.Elah Feder: Me too. Maybe it used to be when people were smoking more.Katie Hafner: Yeah.Elah Feder: But yeah, radon is unfortunately in the lead. Um, Susan's basement: clear of radon.Katie Hafner: And what about genetics? Last week, you know, we talked about a researcher named Maud Slye who worked to show that heredity explained all cancer.Elah Feder: Wrongly, but yes.Katie Hafner: Turns out not to be true, but that's okay. You go Maud. Um, are there genes linked to lung cancer? I guess that's my question.Elah Feder: There are, um, but lung cancer is still, for the most part, a disease caused by- by either your environment or your lifestyle. Some genes have been linked to increased cancer risk. For example, a certain mutation in the EGFR gene. More genes might be found. It's also possible that it's not just about finding a single gene, but about how mutations in a bunch of genes interact. But yeah, for the most part, lung cancer tends to be about environment and lifestyle more than genetics.Here's a part where there's sometimes confusion. Cancer usually happens when there's a genetic mutation in a cell, actually a series of mutations. And these cause that cell to start acting weird and replicating out of control. So in a sense, genetics is always involved in cancer, but in this case, we're not talking about inherited genetics, we're talking about mutations that you get in some of your cells later in life. They can pop up when you're 10 or 30 or 80 or hopefully never. But then, some people do have preexisting germline mutations. Some mutations that you have had since you were a little zygote that exist in every cell of your body. And, these don't usually directly cause cancer on their own. Um, I think an analogy might be helpful here. So, imagine a mutation as a switch. You usually need a few switches to turn on before a cell becomes cancerous. But some people are born with one of their switches already in the on position. And that makes them more vulnerable. Does that make sense?Katie Hafner: It makes sense. It, I mean, it makes me think about the BRCA gene.Elah Feder: Mm-hmm. Exactly.Katie Hafner: So you might be born with this mutation that puts you at high risk of getting breast cancer, but you might still not get it, but it still seems like a good idea to find out if you're at risk so that you can take some precautions and plan ahead.Elah Feder: Right. Although with lung cancer, genetic screening is tricky. Like I mentioned, heredity is not the driving factor usually for this kind of cancer. Um, but say- say you do find you have a heritable mutation that puts you at risk. You're limited in what you can do. It's not like BRCA where you might consider a double mastectomy. You're- you're gonna keep your lungs. You could take extra care to avoid environmental exposures—something we really should all do. You might even get regular low-dose CT scans—that’s actually something that is recommended for people who have smoked after a certain age to detect any lung cancer early, but those come with risks too: you’re getting a little bit of radiation each time. I’m not saying it's not worth it, it might be if you are very high risk, but it's a consideration. Anyway, that's for people who do not have lung cancer already, but are concerned about a genetic predisposition. For someone who does have lung cancer, yeah, you probably want to know what's going on in your tumor genetically.Katie Hafner: So what about Susan's case? Did she find a genetic cause for her lung cancer that could be really useful for her family to know?Elah Feder: No. Um, Susan did not actually test positive for any hereditary mutation linked to cancer, but there are still genes that may not have been identified. Even before her diagnosis, she and her husband were donating money for cancer research through their foundation. After her diagnosis, they ramped this up. Donating to research about immunotherapies, early detection. But, also funding a new project at her sister's Company 23andMe. It's called the Lung Cancer Genetic Study. So, they are trying to build a massive database of genetic information from people with lung cancer.One of the project's goals is to find heritable genetic risk factors, but they explain it's actually bigger than that. They want to know how heritable mutations, tumor mutations, and lifestyle all interact so that they might figure out, for example, why one person who smokes develops cancer, but another doesn't. It might also help them to develop new therapies. So-Katie Hafner: I just wanna interject with something that strikes me just as we're having this conversation, which is that, um, people who are listening to this probably know that 23andMe had a lot of problems, ended up filing for bankruptcy protection and Anne resigned earlier this year. Um, I'm sure that it's been very challenging for Anne, but it sounds like she is in her very best, um, Wojcicki family-like way: making lemonade out of lemons in this regard. That's my initial reaction to everything you're saying.Elah Feder: Yeah. And as you know, 23andMe—while it filed for bankruptcy—it lives on and created a nonprofit called the TTAM Research Institute. It bought 23andMe in July this year. And so, 23andMe is still going and so is this project. So far about 1200 patients have signed up and the goal is to reach 10,000.Anne Wojcicki: If you think about any one medical center, if it's UCSF or at Stanford or Harvard, getting a thousand patients coming in is- is a lot. And so, that's kind of the beauty of being able to go and find people around the entire country, is to be able to pull all that data together and then make that accessible to the research community.Elah Feder: 23andMe's Lung Cancer Genetics Study was officially announced in July last year. Susan Wojcicki died a few weeks later on August 9th, 2024. She was 56.Katie Hafner: So, Susan never did get an answer. She never found out why she had lung cancer.Elah Feder: No, she did not. And we're still trying to understand a lot about lung cancer in general. Here's Anne.Anne Wojcicki: There's still just like a lot you don't know. Understanding environmental science I think is really important. We live in a very complicated world with a lot of, you know, there's fires and there's pollution and there's what you eat and we just don't know. You don't know what the impact of all of that is, and so, you can't- I mean you can't live your life trying to measure everything and worry about everything. Like in some ways you have to come to terms with that, that you can't- you can't worry about it all the time.Elah Feder: This is a big part of life. It's understanding that so much of it is beyond our control, and we often don't even get answers. We don't find out why bad things happen to us. At the same time, when it comes to lung cancer, there is more that we can do. Here's Janet.Janet Wojcicki: I mean, if there are modifiable risk factors that we can identify—I mean the key word being modifiable, right? Then, ideally we could act on them.Elah Feder: We can fight air pollution, we can stop kids from getting their hands on cigarettes. We can look for more heritable risk factors and invest more money in treatments. As for Susan Wojcicki, despite all of her resources and all of her drive, ultimately she couldn't stop the cancer in her own body, but she left her mark in business in cancer research. She left a bigger mark than most of us ever will, but her sisters and her friend, Joanna- the thing that they really remember is how she never let any of that success go to her head.Anne Wojcicki: It didn't matter if we were like some fancy party or if Oprah wanted to talk to her. She was kind of the same. She was always very unaffected. And, it was, like, really fun going to the Oscars with her because she'd be like, “ah, I'm just gonna buy this dress on clearance at Macy's, and like no one cares what I wear.” And that was kind of the thing that was fun. She'd be like, “it would just be fun with you and like only going so that we can hang out.”Anne Wojcicki I always ride in my flats and my skirts. You're going to- are gonna YouTube? I’m actually really curious. Are you gonna meet YouTube- are you gonna meet Mr. Beast?Elah Feder: This episode of Lost Women of Science was produced by me, Elah Feder, and hosted by our co-executive producer Katie Hafner.Our senior managing producer is Deborah Unger. We had fact-checking help from Danya AbdelHameid. Lily Whear made the episode art. Thanks as always. To our co-executive producer, Amy Scharf, Eowyn Burtner, our program manager, and Jeff DelViscio at our publishing partner, Scientific American. This episode was made with funding from the Anne Wojcicki Foundation.You can find a transcript and a link to the Lung Cancer Genetics Study at www.lostwomenofscience.org.HostKatie HafnerHost and Senior ProducerElah FederGuestsAnne Wojcicki Anne is Susan Wojcicki’s youngest sister and the co-founder of 23andMe.Janet WojcickiJanet is the middle Wojcicki sister. She’s a professor of pediatrics and epidemiology at the University of California, San Francisco (UCSF).Joanna StroberJoanna is the co-founder of Midi Health and a long-time friend of Susan Wojcicki.Further Reading“From Susan” — Susan Wojcicki’s final post, written a few weeks before she died and published on YouTube’s blog on Nov. 25, 2024.How to Raise Successful People. Esther Wojcicki, Houghton Mifflin Harcourt, 2019The Lung Cancer Genetics Study“Does Lung Cancer Attract Greater Stigma Than Other Cancer Types?” by Laura A. V. Marlow et al., in Lung Cancer, Vol. 88, No. 1; April 2015

The conservative parties can change their leaders – but it won’t stop the NSW Coalition’s death spiral | Anne Davies

The Nationals have a new leader in Gurmesh Singh and Kellie Sloane could soon replace Liberal leader Mark Speakman. But the Coalition is fractured on net zeroThe NSW Nationals have a new leader, Gurmesh Singh, and the Liberals will almost certainly follow suit by early next week.It’s desperation politics. Changing leaders will likely do nothing to stop the apparent death spiral the conservative side of politics has inflicted upon itself – in Canberra and now the states. Continue reading...

The NSW Nationals have a new leader, Gurmesh Singh, and the Liberals will almost certainly follow suit by early next week.It’s desperation politics. Changing leaders will likely do nothing to stop the apparent death spiral the conservative side of politics has inflicted upon itself – in Canberra and now the states.If they needed evidence of what the electorate was thinking, it was shouting at them from internal YouGov research presented to the NSW Liberal party room on Tuesday. The party’s MPs and MLCs were considering whether to dump net zero as their federal counterparts did on the weekend.YouGov found only one-third of Australians would now seriously consider voting for the Coalition, the party room was told.It found 26% of Australians who are former Coalition voters won’t seriously consider the Coalition in the future. That’s approximately 5 million voters the Coalition needs to persuade to consider them again, the pollsters said.“Only one in five (21%) of former Coalition voters see the Coalition as being in touch with modern Australia. Only one in four (25%) see them as aligned with their values,” the YouGov report stated.One in two (52%) of former Coalition voters said they would only consider a party ready to govern if it had credible policies to address climate change and its impacts.Without a coherent position on the most pressing problem of our generation – how to slow climate change – voters, in particular younger cohorts, have fled in droves. They are unable to take seriously a political party that ignores the overwhelming scientific consensus and the economics of renewables.The federal Liberals have chosen to dump any semblance of a coherent plan.The NSW Liberals, however, voted on Tuesday to retain a net zero emissions by 2050 target. They are sticking with the bipartisan energy transition roadmap devised by the state Coalition when in government.But how does that work when their federal counterparts are talking up new coal-fired power stations and their junior state partner has abandoned the net zero target?Singh, the NSW National’s newly minted leader, hopes a compromise might be reached – though it takes a vivid imagination to see it working.As the first Indian-Australian to leader a major party, he’s a break from the white male graziers that the NSW National party usually chooses.Singh has a degree in industrial design, has worked in advertising and was previously a big wheel in the blueberry and macadamia industries. He formerly chaired Oz Group Co-op – the major marketing co-operative in the Coffs region.His family is still a major player in the Coffs Harbour blueberry industry, an industry that has divided the local community over rapid rapid expansion, use of pesticides, environmental standards and use of contract labour.Singh is acutely aware that on the north coast, his own and other seats face an existential political threat from the progressive side of politics, in the form of the Greens and teals, who have made action on climate change central to their platforms.The Greens already hold the state seat of Ballina, just north of Singh’s seat. In the 2025 federal election, teal candidate Caz Heize slashed the National’s margin in the seat of Cowper (which includes Coffs Harbour) to 0.14% on a two-party preferred basis.Singh is no Barnaby Joyce or Matt Canavan, dinosaurs of the National party whose mission includes returning Australia to a coal-fired past. But he is of the same party.Asked at his first press conference how he would reconcile the Nationals’ position with that of the Liberals in NSW, Singh highlighted the cost of power, the plight of pensioners in the regions who can’t afford hot showers, and suggested a better-managed rollout was required. He didn’t diss renewables per se.Meanwhile, the Liberals’ leadership drama is still to unfold, probably on Thursday, or possibly early next week.Moderate Kellie Sloane, a former journalist who has been an MP for less than three years, appears to be the frontrunner to replace Mark Speakman.However, Alister Heskens, from the right faction and the manager of opposition business, is also canvassing the numbers.The difficulty for Sloane will be her lack of history in the party and her inexperience in government. Heskens’ challenge is his low profile and convincing colleagues he offers an improvement on Speakman. He is likely to relish attacking Labor more than Speakman does.The NSW Liberals have, at least, heeded the YouGov polling on attitudes to climate change and have not been infected by the nonsense pedalled by Advance and other climate-denying figures on the right.The party issued a statement on Tuesday that it remained “committed to a target of net zero by 2050”.“It’s been our target since 2016. It’s a target to be achieved alongside a focus on energy reliability, affordability, and industrial competitiveness.”

Federal Cash for Lead Pipe Replacement Isn’t Making It to Illinois Communities

This story, a partnership between Grist, Inside Climate News, and Chicago-area public radio station WBEZ, is reproduced here as part of the Climate Desk collaboration. Lead pipes are ubiquitous. At this point, no state has gotten rid of all of its toxic lead service lines, which pipe drinking water to homes and businesses. But some cities like Chicago, New York […]

This story, a partnership between Grist, Inside Climate News, and Chicago-area public radio station WBEZ, is reproduced here as part of the Climate Desk collaboration. Lead pipes are ubiquitous. At this point, no state has gotten rid of all of its toxic lead service lines, which pipe drinking water to homes and businesses. But some cities like Chicago, New York City, and Detroit have more lead plumbing than others, and replacing it can cost tens of thousands of dollars. The Infrastructure Investment and Jobs Act, the Biden-era infrastructure law, promised $15 billion for lead pipe replacements across the country to be disbursed over five years.  But in a letter to the Environmental Protection Agency sent earlier this week, a group of Illinois congressional delegates allege that $3 billion appropriated for lead pipe replacements nationwide for the fiscal year that ended in September has not reached communities yet. They warn that the delay is a “dangerous politicization” that puts children and families at risk. “It feels like it’s targeting blue states or blue cities that might require more of this mitigation.” “Federal resources are not partisan tools—they are vital lifelines intended to serve all Americans,” the letter notes. “Using federal funds as leverage against communities based on political considerations represents a dangerous abuse of power that undermines public trust and puts lives at risk.”  The move comes as communities in Illinois, which is among the top five states with the most lead service lines, and across the country are grappling with the overwhelming cost of removing the hazardous metal piping from water systems. The Trump administration has already withheld congressionally appropriated funding for infrastructure and energy projects from Democrat-led states like New York, Colorado, Minnesota, New York, and Massachusetts. Now, lawmakers fear money for lead pipes is stuck in Washington too.  “I think that they’re playing games,” said Rep. Raja Krishnamoorthi, one of the lawmakers who led the effort to send the letter. “It feels like it’s targeting blue states or blue cities that might require more of this mitigation than other parts of the country.”  Lead is toxic and dangerous to human health. Lead plumbing can flake and dissolve into drinking water, which can lead to brain damage, cardiovascular problems, and reproductive issues. The EPA advises that there is no safe level of lead exposure. A spokesperson for the federal agency said it is “actively working” on allotments for lead service line replacements. The Illinois Environmental Protection Agency, which is responsible for disbursing the federal funds to local governments, did not respond to a request for comment. The Chicago Department of Water Management said it received $14 million from the Illinois EPA for the 2025 financial year and was approved for $28 million for the next fiscal year.   “The estimated replacement cost for the Chicago region alone is $12 billion or more, and statewide, it could be $14 billion,” Krishnamoorthi said. “Whatever amounts would come to Chicago would not be enough to do the entire job, but the federal component is vital to get the ball rolling.” Chicago has more than 412,000 lead service lines, the most of any city in the country. So far, the city has replaced roughly 14,000 lead pipes at a cost of $400 million over the past five years. That’s due in part to the high cost of replacing lead pipes. In Chicago, a single lead pipe replacement can cost on average $35,000. Federal rules require that Chicago replace all its pipes by 2047, but city officials have cited concerns over the unfunded federal mandate.  “This is impacting people’s health,” said Chakena Sims, a senior policy advocate with Natural Resources Defense Council. “The federal government politicizing access to safe drinking water is an all-time low,” she added. “It’s encouraging to see our Illinois congressional leaders stand up for communities.”  

Best Leaders 2025: John Palfrey

From finding MacArthur ‘geniuses’ to funding transformative change

John Palfrey is used to thinking about the biggest issues confronting society and what we should all do about them. And in these turbulent times, Palfrey, the president of the John D. and Catherine T. MacArthur Foundation, has reaffirmed his and the foundation's commitment to supporting democracy, creativity, learning and diversity.“I have a relentlessly positive nature, and I do, for better and for worse, often see what is possible and then have the temerity to think we can go get it,” Palfrey said in an interview with U.S. News & World Report. “I think that form of optimism is very helpful, particularly on the darkest of days.”With $9.2 billion in assets, the MacArthur Foundation is one of the nation’s largest philanthropic organizations. In 2024 alone, the foundation paid out more than $350 million in grants. This year, the foundation announced it would increase its grants for 2025 and 2026 because of the federal government’s cuts to funding – which could be devastating for the arts, environmental protection, public safety and more.Meet America's Best LeadersU.S. News & World Report selected its 2025 Best Leaders in public service, business, healthcare and education.See the Top 25 of '25The foundation makes “Big Bets,” investing in initiatives intended to bring about transformative change. For example, in October, the foundation announced it would participate in Humanity AI, an initiative to help ensure that artificial intelligence is a positive tool for society, funding efforts to safeguard democracy from negative effects of the new technology and to protect artists and other creators from theft of their intellectual property.MacArthur also makes “enduring commitments” to invest in journalism that promotes inclusive news narratives and supports a healthy democracy, and it funds initiatives in Chicago, where it is headquartered, to support racial equity and a more inclusive community.It’s perhaps most famous for the MacArthur Fellowships – referred to as “genius grants” – which award 20 to 30 extraordinary creative people in various fields with $800,000 each over a five-year period.Palfrey, 53, likens the foundation to “sort of a nonprofit venture capital” fund.“We prize creativity and effectiveness. And so we are constantly looking for people and institutions and networks that are creative and have new ideas and different ways of approaching topics,” he says.As an educator and acclaimed legal scholar who previously worked at Harvard University and Phillips Academy, Andover, Palfrey has studied some of the most complex challenges facing a democratic society – such as education’s need to respect both free speech and diversity and the influence of technology on society. He understands the fraught nature of these issues and has written seven books, such as “Safe Spaces, Brave Spaces,” to address them head-on.But Palfrey did not anticipate the recent need to advocate for American democracy itself.“The First Amendment, our freedom of expression, the freedom of the press, the freedom to give, the freedom to invest,” he says. “These are 250-year-old American traditions that are unbroken.” And all of a sudden, he says, “they need advocates in a way that they haven’t before.”In addition to the foundation’s ongoing support of the independent press, Palfrey has spearheaded the creation of Press Forward, a new initiative supported by several foundations to rebuild local news.He’s also been touring the country to speak on the importance of democracy and the First Amendment as well as continuing that dialogue in essays and social media.Watching other institutions, such as universities, agree to substantial changes in policy in light of federal government demands, Palfrey thought of historian Timothy Snyder’s first rule for resisting tyranny: “Do not obey in advance.” So, in April 2025, Palfrey and colleagues at other foundations decided to “unite in advance,” issuing a statement that they must have the freedom to give to the causes they believe in. More than 700 foundations from across the ideological spectrum have since signed on.

‘They’re playing games’: Illinois lawmakers press Trump administration over stalled lead-pipe funding

Congress appropriated $15 billion to replace lead pipes across the country. Is the Trump administration withholding it?

Lead pipes are ubiquitous. At this point, no state has gotten rid of all of its toxic lead service lines, which pipe drinking water to homes and businesses. But some cities like Chicago, New York City, and Detroit, have more lead plumbing than others, and replacing it can cost tens of thousands of dollars. The Infrastructure Investment and Jobs Act, the Biden-era infrastructure law, promised $15 billion for lead pipe replacements across the country to be disbursed over five years.  But in a letter to the Environmental Protection Agency sent earlier this week, a group of Illinois congressional delegates allege that $3 billion appropriated for lead pipe replacements nationwide for the fiscal year that ended in September has not reached communities yet. They warn that the delay is a “dangerous politicization” that puts children and families at risk. “Federal resources are not partisan tools — they are vital lifelines intended to serve all Americans,” the letter notes. “Using federal funds as leverage against communities based on political considerations represents a dangerous abuse of power that undermines public trust and puts lives at risk.”  The move comes as communities in Illinois, which is among the top five states with the most lead service lines, and across the country are grappling with the overwhelming cost of removing the hazardous metal piping from water systems. The Trump administration has already withheld congressionally appropriated funding for infrastructure and energy projects from Democrat-led states like New York, Colorado, Minnesota, New York, and Massachusetts. Now, lawmakers fear money for lead pipes is stuck in Washington too.  “I think that they’re playing games,” said Representative Raja Krishnamoorthi, one of the lawmakers who led the effort to send the letter. “It feels like it’s targeting blue states or blue cities that might require more of this mitigation than other parts of the country.”  Lead is toxic and dangerous to human health. Lead plumbing can flake and dissolve into drinking water, which can lead to brain damage, cardiovascular problems, and reproductive issues. The EPA advises that there is no safe level of lead exposure. A spokesperson for the federal agency said it is “actively working” on allotments for lead service line replacements. The Illinois Environmental Protection Agency, which is responsible for disbursing the federal funds to local governments, did not respond to a request for comment. The Chicago Department of Water Management said it received $14 million from the Illinois EPA for the 2025 financial year and was approved for $28 million for the next fiscal year.   “The estimated replacement cost for the Chicago region alone is $12 billion or more, and statewide, it could be $14 billion,” Krishnamoorthi said. “Whatever amounts would come to Chicago would not be enough to do the entire job, but the federal component is vital to get the ball rolling.” Chicago has more than 412,000 lead service lines, the most of any city in the country. So far, the city has replaced roughly 14,000 lead pipes at a cost of $400 million over the past five years. That’s due in part to the high cost of replacing lead pipes. In Chicago, a single lead pipe replacement can cost on average $35,000. Federal rules require that Chicago replace all its pipes by 2047, but city officials have cited concerns over the unfunded federal mandate.  “This is impacting people’s health,” said Chakena Sims, a senior policy advocate with Natural Resources Defense Council. “The federal government politicizing access to safe drinking water is an all-time low,” she added. “It’s encouraging to see our Illinois congressional leaders stand up for communities.”   This story was originally published by Grist with the headline ‘They’re playing games’: Illinois lawmakers press Trump administration over stalled lead-pipe funding on Nov 13, 2025.

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